LEAPS-MPS: Development of Carbodiphosphorane Catalysts for Organic and Polymer Synthesis

LEAPS-MPS：用于有机和聚合物合成的碳二磷烷催化剂的开发

基本信息

批准号：
2213507
负责人：
Allegra Liberman-Martin
金额：
$ 23.54万
依托单位：
Chapman University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2213507&HistoricalAwards=false
关键词：
LEAPS MPS Development Carbodiphosphorane Catalysts

项目摘要

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). In this project, funded by the Mathematical and Physical Sciences Directorate and housed in the Chemistry Division, Professor Allegra Liberman-Martin and undergraduate students at Chapman University will develop metal-free catalysts for the sustainable preparation of small organic molecules and polymers. Many current catalysts use expensive, rare, or toxic metals, creating an ongoing need to develop efficient and robust catalysts based on earth-abundant elements. The Prof. Liberman-Martin and her students will study catalysts that feature neutral, electron-rich carbon centers. This investigation will improve understanding of reaction pathways for electron-rich carbon catalysts while also providing new catalytic methods involving ester substrates, which are found in biomass and plant-based oils. Prof. Liberman-Martin’s broadening participation plan creates an orientation program, one-semester research opportunity, and monthly workshop series for STEM transfer students at Chapman University.Prof. Liberman-Martin and Chapman University undergraduates will study the organocatalytic reactivity of carbodiphosphoranes and phosphorus ylides. Both catalyst categories feature an electron-rich carbon center flanked by one or two phosphorus substituents. Although carbodiphosphoranes have been investigated as ligands to support inorganic complexes and phosphorus ylides are commonly used as reagents for organic synthesis, their catalytic behavior remains relatively unexplored. This project studies catalysis in the context of ester derivatization and targets both ester reduction and ring-opening polymerization reactions. Discoveries from this project have the potential to broaden the organocatalytic methods available to chemists and improve the fundamental understanding of carbodiphosphorane structure and reactivity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项全部或部分由《2021 年美国救援计划法案》（公法 117-2）资助。在该项目中，由数学和物理科学理事会资助，由 Allegra Liberman-Martin 教授和化学部负责。查普曼大学的本科生将开发无金属催化剂，用于可持续制备小有机分子和聚合物。目前许多催化剂使用昂贵、稀有或有毒的金属，因此迫切需要开发高效且高效的催化剂。利伯曼-马丁教授和她的学生将研究具有中性、富电子碳中心的催化剂，这项研究将增进对富电子碳催化剂反应途径的理解，同时提供新的催化作用。 Liberman-Martin 教授的扩大参与计划为 STEM 转学生提供了定向计划、一学期的研究机会和每月研讨会系列。查普曼大学利伯曼-马丁教授和查普曼大学的本科生将研究碳二膦和磷叶立德的有机催化反应性，尽管碳二膦已被研究作为配体来支持。无机配合物和磷叶立德通常用作有机合成试剂，但它们的催化行为仍然相对未经探索。该项目研究酯衍生化背景下的催化作用，并针对酯还原和开环聚合反应。该项目的发现有可能拓宽化学家可用的有机催化方法，并提高对碳二膦结构和反应性的基本了解。该奖项。通过使用基金会的智力价值和更广泛的影响审查标准进行评估，NSF 的法定使命被认为值得支持。