POSE: Phase I: Scoping the transition of Rosetta to a self-sustaining Open Source Ecosystem

POSE：第一阶段：确定 Rosetta 向自我维持的开源生态系统过渡的范围

• 批准号: 2229291
• 负责人: Neil King
• 金额: $ 30万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2229291&HistoricalAwards=false
• 关键词: POSE; Phase; Scoping; transition; Rosetta

This project is funded by Pathways to Enable Open-Source Ecosystems (POSE) which seeks to harness the power of open-source development for the creation of new technology solutions to problems of national and societal importance. The Rosetta community has led the field of protein and RNA modeling and design for the last two decades with state-of-the-art biomolecular modeling and design software, high-impact scientific advances enabled by the software, and a workforce with best-in-class biomolecular engineering training. The biomolecular modeling landscape is rapidly changing with the emergence of powerful machine learning methods, and the recent entry of several computationally designed proteins into clinical trials have marked an inflection point in the history of the field. These disruptions have prompted the Rosetta community to reimagine their practices to enable continued leadership and innovation in the next era of biomolecular modeling. Specifically, Rosetta’s existing paid commercial license model limits Rosetta’s accessibility and impact, and de-incentivizes critical contributions from industry scientists.Second, Rosetta's remarkable success has led to dramatic expansion of both the software and community, yet the operational structure of the community has not been updated accordingly, limiting workforce growth, software development, and the diversity of perspectives thatultimately lead to higher-impact scientific advances. This project will create opportunities for coordinated and strategic software development by leveraging, growing, and supporting the Rosetta community to provide best-in-class software. The project will serve the national interest by driving the next generation of the leading biomolecular modeling and design software that enables scientific discovery and innovation across the health, food, and energy sectors.This research will scope and build an open-source ecosystem (OSE) for the Rosetta software and community. Specifically, the goals are to: (1) Create a Strategic Plan that aligns efforts and drives progress by identifying high-impact opportunities in the biomolecular modelingand design ecosystem that the software, science, and community embodied in a Rosetta OSE will realize; (2) Define an organizational structure capable of rapid and informed decision-making, empowering community members and leaders in a “do-ocracy” such thatscientific discovery, code development, and community engagement are all equally incentivized; and (3) Identify long-term funding and social engagement strategies that yield expanded and active user- and contributor-bases that sustain Rosetta’s impact and leadership. Learn more about Rosetta at http://www.rosettacommons.org.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目的资助是由促进开源生态系统（姿势）的途径，该途径旨在利用开源开发的力量来为国家和社会重要性问题创建新技术解决方案。在过去的二十年中，罗塞塔社区（Rosetta Community）领导了蛋白质和RNA建模和设计领域，并采用了最先进的生物分子建模和设计软件，该软件实现的高影响力科学进步以及具有一流的生物分子工程培训的劳动力。随着强大的机器学习方法的出现，生物分子建模格局正在迅速变化，并且最近将几种计算设计的蛋白质进入临床试验中，这标志着该领域历史上的影响点。这些破坏促使罗塞塔社区重新构想了他们的实践，以使下一个生物分子建模时代继续领导和创新。具体而言，罗塞塔（Rosetta）现有的付费商业许可模型限制了罗塞塔（Rosetta）的可及性和影响力，并消除了行业科学家的关键贡献。第二，罗塞塔（Rosetta）的杰出成功导致了软件和社区的巨大扩展，但是社区的运营结构却没有相应地更新，限制了劳动力增长，软件发展，以及较高的努力，以限制了与多样性的促进，并具有多样性的指导，以提高到多样性的范围。该项目将通过利用，成长和支持Rosetta社区提供一流的软件来为协调和战略性软件开发创造机会。该项目将通过推动下一代领先的生物分子建模和设计软件来为国家利益提供服务，该软件能够在整个健康，食品和能源领域促进科学发现和创新。这项研究将为Rosetta软件和社区建立开源生态系统（OSE）。具体而言，目标是：（1）制定一项战略计划，通过确定在Rosetta Ose中体现的软件，科学和社区中的生物分子建模和设计生态系统中的高影响力的机会来稳定努力并推动进步； （2）定义一个能够快速有明智的决策的组织结构，使社区成员和领导者具有“尊贵”的能力，以便使科斯科的发现，代码发展和社区参与都同样激励； （3）确定长期资金和社会参与策略，这些策略产生了维持Rosetta的影响力和领导能力的扩展和积极的用户和贡献者。在http：//www.rosettacommons.org..org上了解有关Rosetta的更多信息，该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响评估标准，被认为是珍贵的支持。