SBIR Phase I: A Universal Connector for High-Density Microfluidic Chip Interfaces

SBIR 第一阶段：用于高密度微流控芯片接口的通用连接器

• 批准号: 2151449
• 负责人: Trevor McQueen
• 金额: $ 25.6万
• 依托单位: Neptune Fluid Flow Systems LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2151449&HistoricalAwards=false
• 关键词: SBIR; Phase; Universal; Connector; Density

The broader impact of this Small Business Innovation Research (SBIR) Phase I project is to advance the lab-on-a-chip and other related life science platforms by the introduction of a new standardized microfluidic chip interface. The proposed project advances a novel interface to advance the applications and capabilities of microfluidic chips in both medical and non-medical fields, including dramatically increasing the rate at which doctors and medical researchers can prepare and perform diagnostic tests. The interface enables easy interoperability of devices as the chips can be freely switched out while the result of the hardware remains the same. The success of this project could lead to great breakthroughs in bioenergy, medical diagnostics, and drug therapeutics.The proposed project undertakes the development of chip interfaces with reduced size and increased channel density by making use of novel interfacing and sealing methods, on a reusable micro-patterned surface. While the technology exists to fabricate microfluidic chips with much smaller dimensions, with more complex on-chip operations, and at a reduced cost, the current limitation is the size of the interfaces bridging the microscopic world of the fluid microchip with the macroscopic world of the laboratory. The work proposed herein could enable chips with 16x the density of sample channels, allowing for vastly more complex diagnostics to be performed and thereby vastly reducing the sample volume needed for accurate diagnostics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I阶段项目的更广泛影响是通过引入新的标准化微流体芯片界面来推动实验室和其他相关的生命科学平台。拟议的项目推进了一个新型的界面，以提高微流体芯片在医疗和非医疗领域的应用和能力，包括大大提高医生和医学研究人员可以准备和执行诊断测试的速度。该界面可以轻松地互操作设备，因为可以自由切换芯片，而硬件的结果保持不变。该项目的成功可能会导致在生物能源，医学诊断和药物治疗学方面取得巨大的突破。拟议项目通过利用新型的接口和密封方法来开发具有较小尺寸的芯片界面，并在可重复使用的微图表上使用新颖的接口和密封方法。尽管该技术的存在是为了制造具有较小尺寸的微流体芯片，并且具有更复杂的芯片操作，并且以降低的成本进行了限制，但目前的限制是桥接流体微芯片与实验室的微观世界的微观世界的界面的大小。本文提出的工作可以使芯片具有16倍的样本通道密度，从而可以执行更复杂的诊断，从而大大减少了准确诊断所需的样本量。该奖项反映了NSF的法定任务，并通过使用该基金会的知识分子优点和广泛的影响来评估NSF的法定任务，并被视为值得的支持。