PFI-TT: Achieving efficient production of visible light from semiconductor nanocrystals in water

PFI-TT：实现水中半导体纳米晶体高效产生可见光

• 批准号: 2147791
• 负责人: Ming Tang
• 金额: $ 25万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2147791&HistoricalAwards=false
• 关键词: PFI; TT; Achieving; efficient; production

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project is a nanocrystal-based light absorber that converts near infrared (NIR) to visible light in biologically friendly aqueous media. This project addresses unmet needs in the life sciences where the deep targeted delivery of light to tissue is needed because it is currently impossible deliver violet light deep inside living mammals without surgery or using a very intense laser that exceeds the mammalian pain threshold. This project will advance the development of a prototype system. The ability to deliver violet light non-invasively centimeters below the skin will facilitate new ways to detect oxygen (hypoxia) and create inexpensive light sources for point-of-care (POC) diagnostics. Potential commercial applications include mapping neural networks, mitigating pain, artificially controlling the circadian rhythm, alleviating depression, and imaging physiological processes in preclinical research. Apart from impact in these large and growing billion-dollar markets, this innovation will enable new directions in the diverse academic fields of neuroscience, light-sheet imaging and circadian rhythm research. The proposed project will establish novel methods for stabilizing hydrophobic nanocrystals and molecular antennas in water. The goals are to realize state-of-the art photon upconversion quantum yields with this hybrid platform in aqueous media, as opposed to previous records in organic solvent. Research objectives include establishing a kinetic or thermodynamic barrier that isolates the semiconductor nanocrystals and molecular emitters from their aqueous surroundings while preventing quenching by ambient oxygen. The nano- or micro-vesicles or emulsions proposed here will be stabilized by fine-tuning the relative ratios of various components and their differing solubilities. The spin-triplet excited state necessary for high photon upconversion quantum yields will be protected against undesired quenching by oxygen with chemical barriers or additives.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这种创新合作伙伴关系的更广泛的影响/商业潜力 - 技术翻译（PFI-TT）项目是一个基于纳米晶体的光吸收器，将接近红外线（NIR）转换为生物友好的水性水性介质中的可见光。该项目解决了需要深层靶向光向组织的生命科学中未满足的需求，因为目前不可能在没有手术的情况下将紫罗兰色的光在活哺乳动物的内部深处传递，或者使用超过哺乳动物疼痛阈值的非常激烈的激光。该项目将推动原型系统的开发。在皮肤下方提供紫罗兰色的非侵入性厘米的能力将有助于检测氧气（缺氧）并创造出廉价的护理（POC）诊断的廉价光源。潜在的商业应用包括映射神经网络，缓解疼痛，人为地控制昼夜节律，减轻抑郁症以及临床前研究中的成像生理过程。除了在这些庞大而增长的十亿美元市场中的影响之外，这项创新还将在神经科学，灯页成像和昼夜节律研究的各种学术领域提供新的方向。拟议的项目将建立稳定水中疏水纳米晶体和分子天线的新方法。与以前的有机溶剂记录相反，该目标是通过此混合介质中的此混合平台实现最先进的光子上转换量子量产率。研究目标包括建立动力学或热力学屏障，该屏障将半导体纳米晶体和分子发射器与水性周围环境分离，同时防止环境氧气淬火。此处提出的纳米或微源或乳液将通过微调各种组件的相对比及其不同的溶解度来稳定。高光子上转音量量子收益率所需的自旋三重激发状态将受到保护，以防止用化学障碍或添加剂用氧气进行不需要的淬火。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子和更广泛的影响来通过评估来支持的。审查标准。

项目成果

Photon Upconversion in the Visible Wavelengths with ZnSe/InP/ZnS Nanocrystals

• DOI: 10.1021/acs.jpcc.2c07860
• 发表时间: 2023-01
• 期刊: The Journal of Physical Chemistry C
• 作者: Paulina Jaimes;Tsumugi Miyashita;Tian Qiao;Kefu Wang;M. Tang