CAREER: LUCO: A Noninvasive Miniaturized Blood Gas Sensor for Respiration Monitoring

职业：LUCO：用于呼吸监测的无创微型血气传感器

• 批准号: 2143898
• 负责人: Ulkuhan Guler
• 金额: $ 50万
• 依托单位: Worcester Polytechnic Institute
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2143898&HistoricalAwards=false
• 关键词: CAREER; LUCO; Noninvasive; Miniaturized; Blood

Among the vital signs of human health, respiratory parameters are key indicators of the physiological status of the human body. The accurate diagnosis of respiratory diseases mandates a measure of blood gases. The determination of blood gases requires an arterial blood sample, an invasive and painful process. This procedure, however, provides only a discrete measurement of respiratory efficacy during a rapidly changing situation. Transcutaneous monitoring is a noninvasive method of continuously measuring oxygen and carbon dioxide diffused through the skin, and any changes they undergo correlate closely with changes in blood gases. The contemporary methodology for measuring transcutaneous oxygen and carbon dioxide requires a heated sensor (that may burn the skin and require frequent alteration of the sensing spot) and a costly non-portable, bulky, corded sensing unit. This project will address a critical unmet need for a cost-effective noninvasive miniaturized wearable device capable of sensing multiple blood gas parameters that provide a comprehensive picture of one’s respiratory status from a home setting. The continuous and remote tracking of vital respiratory parameters will provide relevant and accurate data that alert a caregiver and influence the course of treatment. As the proposed system enables massive longitudinal blood gas data collected in non-clinical settings, clinicians and researchers can remotely assess and measure pulmonary outcomes objectively, and clinicians can further improve the home care management of patients with a fragile respiratory status. The educational program complementing this award will support STEM engagement in schools, provide research opportunities for underrepresented groups - particularly women, train students in state-of-the-art circuits and systems, biomedical, and optics, and support the future engineering workforce.This project will create a first-of-its-kind wearable blood gas monitor for managing the home care of individuals. More specifically, the core scientific contributions will include 1) the creation of a novel miniaturized custom-designed wearable sensor that measures two modalities of blood gases; 2) identification of factors affecting sensor readings such as temperature and drift for the self-calibration of blood gas sensors; 3) the exploration of innovative electronic interfaces for a specialized analog front-end for the proposed unique sensor with heterogeneous decay time, including one with an ultra-fast response; 4) determination of the feasibility and usability of the system during real-life activities in home settings by capturing the dynamic respiratory physiological status of individuals with longitudinal data. Having the ability to sense two vital respiratory parameters (namely, transcutaneous partial pressures of oxygen and carbon dioxide) with one wearable device is unique and superior to the current practice of measuring only oxygen saturation, and fills an important gap in the miniaturization of the transcutaneous blood gas sensor for noninvasive wearable device applications. In addition, the longitudinal new data will enable new biomedical research opportunities to assess therapies and further investigate medical conditions in which oxygen and carbon dioxide play a critical role, including novel respiratory diseases that are not yet fully understood (e.g., COVID-19). Progress on enabling the affordable and scalable remote monitoring of oxygenation and ventilation at home is transformative for prospective medical and scientific research.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在人类健康的生命体征中，呼吸参数是人体身体状况的关键指标。呼吸道疾病的准确诊断要求测量血液气体。血液的确定需要伪像，这是一个侵入性和痛苦的过程。但是，此过程仅提供了在快速变化的情况下对呼吸有效性的离散度量。经皮监测是一种无创的方法，可以连续测量氧气和二氧化碳在皮肤中扩散，并且与血液气体变化紧密相关的任何变化。测量经皮氧和二氧化碳的当代方法需要加热的传感器（可能会燃烧皮肤并经常改变感应点），并且是一个昂贵的，不可支配的，笨重的，有线的感官单元。该项目将解决对具有成本效益的非侵入性微型可穿戴设备的至关重要的需求，能够感知多个血液参数，从而为您从家庭环境提供了全面的呼吸状态。对重要呼吸参数的持续远程跟踪将提供相关和准确的数据，以提醒护理人员并影响治疗过程。由于提出的系统可以在非临床环境中收集的大量纵向血液数据，因此临床医生和研究人员可以客观地评估和衡量肺部的结局，临床医生可以进一步改善易碎呼吸状况的患者的家庭护理管理。理解该奖项的教育计划将支持STEM参与学校，为代表性不足的群体（尤其是妇女，培训学生使用最先进的电路和系统，生物医学和光学）的研究机会，并支持未来的工程劳动力。该项目将创建一个首先的可耐磨性血液燃气监测员，以管理个人护理。更具体地说，核心科学贡献将包括1）创建一种新型的微型定制设计的可穿戴传感器，该传感器测量了两种血液的方式； 2）鉴定影响传感器读数的因素，例如温度和驱动因素，以进行血液气体传感器的自我校准； 3）探索具有异质衰减时间的拟议独特传感器的专业模拟前端的创新电子界面，其中包括具有超快速响应的一个； 4）通过捕获具有纵向数据的个体的动态呼吸生理状态，确定在房屋环境中现实生活活动中系统的可行性和可用性。具有感知两个重要的呼吸参数的能力（即使用一个可穿戴设备的氧和二氧化碳的经皮部分压力）具有独特性，并且优于目前仅测量氧气疾病的实践，并且填补了无侵入性易用的耐磨性装置应用的小型差距。此外，纵向新数据将使新的生物医学研究机会评估疗法并进一步研究氧气和二氧化碳发挥关键作用的医疗状况，包括尚未完全了解的新型呼吸道疾病（例如，Covid-19）。在家中实现负担得起且可扩展的远程监控的进展是对前瞻性医学和科学研究的变革性。该奖项反映了NSF的法定任务，并通过使用该基金会的知识分子的优点和更广泛的影响来评估NSF的法定任务，并被认为是宝贵的支持。

项目成果

A Miniaturized Transcutaneous Carbon Dioxide Monitor Based on Dual Lifetime Referencing

基于双寿命参考的小型化经皮二氧化碳监测仪

• DOI: 10.1109/biocas54905.2022.9948600
• 发表时间: 2022
• 期刊: 2022 IEEE Biomedical Circuits and Systems Conference (BioCAS
• 作者: Tufan, Tuna B.;Guler, Ulkuhan
• 通讯作者: Guler, Ulkuhan

A Nonuniform Sampling Lifetime Estimation Technique for Luminescent Oxygen Measurements

发光氧测量的非均匀采样寿命估计技术

• DOI: 10.1109/esscirc55480.2022.9911496
• 发表时间: 2022
• 期刊: IEEE 48th European Solid State Circuits Conference (ESSCIRC
• 作者: Costanzo, Ian;Sen, Devdip;McNeill, John;Guler, Ulkuhan
• 通讯作者: Guler, Ulkuhan

A Miniaturized Prototype for Continuous Noninvasive Transcutaneous Oxygen Monitoring

用于连续无创经皮氧监测的小型化原型

• DOI: 10.1109/biocas54905.2022.9948598
• 发表时间: 2022
• 期刊: 2022 IEEE Biomedical Circuits and Systems Conference (BioCAS
• 作者: Kahraman, Burak;Vakhter, Vladimir;Costanzo, Ian;Bu, Guixue;Foroozan, Foroohar;Guler, Ulkuhan
• 通讯作者: Guler, Ulkuhan