I-Corps: Novel Intermittent Urinary Catheter Design

I-Corps：新颖的间歇性导尿管设计

• 批准号: 2138136
• 负责人: Wayne Hellstrom
• 金额: $ 5万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2138136&HistoricalAwards=false
• 关键词: Corps; Novel; Intermittent; Urinary; Catheter

The broader impact of this I-Corps project is to reduce the incidence of urinary tract infections (UTIs) caused by intermittent urinary catheter use. The main goal is to reduce morbidity and mortality associated with intermittent urinary catheter use, improve quality of life, and significantly reduce the cost to the health care system. This novel intermittent urinary catheter design offers three important advantages, it : eliminates the translocation of bacteria at the urethral opening into the bladder, prevents catheter contamination due to handling, and eliminates frictional stresses imposed on endothelial tissues during catheter insertion. Together, these features are expected to result in a significant reduction of UTI incidence due to intermittent urinary catheter use.This I-Corps project develops a novel intermittent urinary catheter with a sheath, initially stored on the inside of the catheter, that is deployed over the catheter as it advances up the urethra, resulting in sterile material covering the catheter that remains stationary against the urethra as the catheter advances. Before deployment, the sterile sheath is inside the catheter with only a small portion on the outside covering the tip connected to a flange. As the catheter is pushed forward, the flange stays in place and a sterile barrier in put between the catheter and the urethra. This technology would eliminate bacteria at the urethral meatus from reaching the bladder and eliminate frictional damage to tissues, in addition to reducing concerns of improper handling.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响是减少由间歇性尿管使用引起的尿路感染（UTI）的发生率。主要目标是降低与间歇性尿管使用，改善生活质量并大大降低医疗保健系统成本相关的发病率和死亡率。这种新型的间歇性尿管设计具有三个重要优势，它消除了尿道开口处细菌的易位，从而防止了由于处理而导致的导管污染，并消除了插入过程中导管组织对内皮组织施加的摩擦压力。预计，由于间歇性尿管的使用，这些特征有望大大降低UTI发病率。此I-Corps项目开发出一种新型的间歇性尿管导管，并带有鞘，最初在导管内部部署，该导管在导管上储存在导管上，导致尿素材料在尿布中呈现，该导管仍在散发出尿布，该导管仍在散发出尿布，该导管的摄取量是尿布的。在部署之前，无菌鞘在导管内部，外部只有一小部分，覆盖了连接到法兰的尖端。随着导管向前推，法兰停留在适当的位置，并在导管和尿道之间放置无菌壁垒。这项技术还将消除尿道肉类的细菌，从膀胱到达膀胱，消除对组织的摩擦损害，除了减少对处理不当的担忧外，该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子和更广泛影响的评估来通过评估来获得支持的。