ISS: Wicking in gel-coated tubes

ISS：凝胶涂层管中的芯吸作用

• 批准号: 2126465
• 负责人: Emilie Dressaire
• 金额: $ 64.69万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2126465&HistoricalAwards=false
• 关键词: ISS; Wicking; gel; coated; tubes

Surfactant replacement therapies rely on plugs of liquid to carry drugs into the lungs and treat respiratory distress syndrome. The administered liquid plugs travel through airways lined with mucus, a gel that traps inhaled contaminants. The deposition of liquid in the airways is often held responsible for therapeutic failures, yet the influence of the mucus lining on drug delivery remains to be understood. This NSF-CASIS project will conduct experiments onboard the International Space Station (ISS) and on Earth to establish the role of a gel lining in the transport of a liquid plug. The team will examine and explain how the gel's mechanical properties affect the liquid delivery in gravity and microgravity conditions to study the different plug dynamics at high resolution. This project will provide a unique opportunity to train and encourage students and community members to think about biological systems as a source of inspiration for engineering design, in part through ongoing collaborations with the Santa Barbara Zoo and the City of Riverside's Ameal Moore Nature Center.This project aims to develop a comprehensive understanding of free and forced liquid imbibition through gel-coated tubes. The project will investigate how dissipation in the viscoelastic gel at the moving contact lines influences (i) the macroscopic rate of transport of the plug and (ii) the fluid deposition at its trailing edge. The project accomplishes these goals with a combination of extensive experimental and theoretical investigations. The research team will use a model system consisting of a transparent tube lined with a clear gel to image the motion of the liquid and the deformation of the gel. Onboard the ISS, the liquid will spontaneously imbibe the gel-coated tube due to capillarity, while in Earth experiments, gravity will drive its motion in addition to capillary wicking. The team will then develop predictive models for the transport of liquid plugs in small and large ducts, accounting for both the local viscoelastic dissipation in the gel at the moving contact lines and the global viscous dissipation in the viscous fluid plug. This work will provide new insights into the delivery of drugs in the lungs to support improved treatment strategies; the results may also lead to engineering solutions for intermittent flows in pipes.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

表面活性剂替代疗法依靠液体塞将药物携带到肺部并治疗呼吸窘迫综合征。管理的液体塞穿过衬有粘液的气道，粘液夹着吸入污染物的凝胶。液体在气道中的沉积通常是负责治疗衰竭的原因，但是粘液衬里对药物输送的影响仍有待理解。这个NSF-CASIS项目将在国际空间站（ISS）和地球上进行实验，以确立凝胶衬里在液体塞运输中的作用。该团队将检查并解释凝胶的机械性能如何影响重力和微重力条件下的液体输送，以研究高分辨率的不同插头动力学。该项目将为培训和鼓励学生和社区成员将生物系统视为工程设计的灵感来源，部分是通过与圣塔芭芭拉动物园和里弗赛德市的艾米尔·摩尔自然中心进行的，该项目旨在通过Gel涂层的管子对免费和强制的液体进行全面了解。该项目将研究在移动接触线处的粘弹性凝胶中的耗散如何影响（i）插头的宏观运输速率以及（ii）其后端的流体沉积。该项目通过广泛的实验和理论研究结合了这些目标。研究团队将使用由透明的管子衬有透明凝胶的透明管组成的模型系统来对液体的运动和凝胶的变形进行成像。在ISS上，由于毛细管性，液体会自发地吸收凝胶涂层的管子，而在地球实验中，重力除毛细管焊外还会驱动其运动。然后，该团队将开发用于将液体塞在大小管中运输的预测模型，这既是凝胶中移动接触线上凝胶中的局部粘弹性耗散，又是粘性流体插头中的全球粘性耗散。这项工作将为肺中的药物提供新的见解，以支持改进的治疗策略；结果还可能导致管道间歇流的工程解决方案。该奖项反映了NSF的法定任务，并且使用基金会的知识分子优点和更广泛的影响评估标准，被认为值得通过评估来获得支持。

项目成果

Rotation–translation coupling of soft objects in lubricated contact

润滑接触中软物体的旋转和平移耦合

• DOI: 10.1039/d2sm00434h
• 发表时间: 2022
• 期刊: Soft Matter
• 影响因子: 3.4
• 作者: Kargar-Estahbanati, Arash;Rallabandi, Bhargav
• 通讯作者: Rallabandi, Bhargav