MRI Consortium: Development of Dynamic PicoProbe for Multi-Modal, Multi-Dimensional HyperSpectral Imaging of Soft/Hard Matter and Interfaces in Environmental Media

MRI 联盟：开发动态 PicoProbe，用于环境介质中软/硬物质和界面的多模态、多维高光谱成像

• 批准号: 2117896
• 负责人: Junhong Chen
• 金额: $ 202.16万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117896&HistoricalAwards=false
• 关键词: MRI; Consortium; Development; Dynamic; PicoProbe

This Major Research Instrumentation (MRI) award by both the Division of Materials Research (DMR) in the Directorate for Mathematical & Physical Sciences (MPS) and the Division of Civil, Mechanical and Manufacturing Innovation (CMMI) in the Directorate for Engineering (ENG) supports the development of a nanoscale metrological resource, the Dynamic PicoProbe, to enable quantitative investigations of liquid/solid/hard/soft matter interfaces for time-resolved high-resolution in-situ environmental observations using advanced analytical electron microscopy. Funding this instrument development allows advancement in several areas relevant to engineering and materials research with applications in the water-energy nexus, catalysis, quantum electronics, bioelectronics, cancer therapy, and protein engineering. The project creates a national user-accessible resource and offers unique opportunities to train students, postdocs, novice and experienced researchers through collaborative investigations. Central to this instrument-development project is training next-generation instrumentalists with targeted technical and professional skillsets critical to their career advancements. The Dynamic PicoProbe instrument features new structured illumination optics and machine learning/artificial intelligence analysis software for real-time data processing to improve temporal measurement capabilities at the nanoscale in environmental media by one order of magnitude. Both optics and software are integrated with state-of-the-art detectors into an existing best-of-class analytical microscope. The project leads to an electron-optical beam line having the elemental sensitivity ( 1% minimum mass fraction) and image resolution ( 0.1 nm) required to capture localized and individual dynamic events ( 3 ms) at solid-liquid or solid-gas interfaces. Such measurements are critical to advance multiple frontiers in science and engineering, such as engineered nanomaterials, organic/inorganic heterostructures, biointerfaces, macromolecular complexes, and quantum electronics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

材料研究部（DMR）在数学和物理科学局（MPS）（MPS）和民用，机械和制造创新（CMMI）在工程局（ENG）中的这项主要研究工具（MRI）奖，以及民用，机械和制造创新（CMMI）的划分，支持纳米级计数资源的开发，以实现液体/固体量的固体/固体量，以实现动态/固体范围，以实现较智能/固体范围，以促进智力/固体范围，以促进智力/固体范围的范围/固体。使用高级分析电子显微镜进行高分辨率的原位环境观测。资助这种仪器的开发允许在与工程和材料研究有关的多个领域，并在水能Nexus，催化，量子电子，生物电子，癌症治疗和蛋白质工程中应用。该项目创建了一个全国用户可访问的资源，并通过协作调查为培训学生，博士后，新手和经验丰富的研究人员提供了独特的机会。该仪器开发项目的核心是培训下一代乐器演奏家，其针对性的技术和专业技能对他们的职业发展至关重要。 动态的Picoprobe仪器具有新的结构化照明光学和机器学习/人工智能分析软件，用于实时数据处理，以通过一个数量级来提高环境媒体中纳米级的时间测量功能。光学和软件都将最佳检测器集成到现有的最佳分析显微镜中。该项目导致具有元素灵敏度（最小质量分数1％）和图像分辨率（0.1 nm）的电子光束线，以捕获固体液体或固体气体接口处的局部动态事件（3 ms）所需的图像分辨率（0.1 nm）。此类测量对于推进科学和工程的多个前沿至关重要，例如工程纳米材料，有机/无机异质结构，生物结构，生物结构，大分子分子复合物和量子电子学。这奖反映了NSF的法定任务，并通过使用基础的智力效果和宽阔的范围进行评估，以评估值得评估。

项目成果

Optimized Amplitude-Dividing Beam Splitter Gratings for 4D STEM Holography

用于 4D STEM 全息术的优化分幅分束器光栅

• DOI: 10.1017/s1431927621003007
• 发表时间: 2021
• 期刊: Microscopy and Microanalysis
• 影响因子: 2.8
• 作者: Ducharme, Andrew;Johnson, Cameron;Ercius, Peter;McMorran, Benjamin
• 通讯作者: McMorran, Benjamin

In-situ TEM Investigation of Void Swelling in Nickel under Irradiation with Analysis Aided by Computer Vision

• DOI: 10.1016/j.actamat.2023.119013
• 发表时间: 2023-05
• 期刊: Acta Materialia
• 影响因子: 9.4
• 作者: Wei-Ying Chen;Z. Mei;Logan Ward;Brandon Monsen;J. Wen;N. Zaluzec;A. Yacout;Meimei Li