MRI: Acquisition of a benchtop cell sorter to advance undergraduate research and training in biology at Lewis & Clark College

MRI：购买台式细胞分选仪以推进刘易斯生物学本科生研究和培训

• 批准号: 2117304
• 负责人: Sharon Torigoe
• 金额: $ 12.5万
• 依托单位: Lewis and Clark College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117304&HistoricalAwards=false
• 关键词: MRI; Acquisition; benchtop; cell; sorter

An award is made to Lewis & Clark College to acquire a benchtop cell sorter, which will facilitate innovative and cutting-edge research in at least three laboratories on campus. Cell sorting is a method used to characterize, separate, and collect cells or organelles from a heterogeneous population based on physical, chemical and/or molecular properties. The acquisition of a cell sorter will support the Biology Department in providing meaningful research experiences and training in the biological sciences to undergraduate students. By expanding the range of approaches available on campus, this instrument will broaden the research capacity at Lewis & Clark College and enhance opportunities for undergraduate students working in faculty research labs. The cell sorter also will be incorporated into laboratory courses, even at the introductory-level, in which students are trained to design and carry out their own original, independent research projects.Cell sorting has becoming increasingly common and necessary in biological research, due to advancements in experimental methods and a deeper appreciation for studying unique cell-types and organelles. Genomics and proteomics technologies are now more sensitive, efficient, and affordable, creating new opportunities to analyze specific cells and organelles that are collected by cell sorting. Recent developments also have made gene editing easier and more accessible, and best practices employ a cell sorter to select genetically altered cells. The availability of a cell sorter, therefore, will support and advance research in at least three laboratories at Lewis & Clark College to employ these modern methods towards gaining new insight into biological processes. These include studies into the mechanisms of cell-specific gene regulation, the effects of developmental nicotine exposure in D. melanogaster, and the functions of lysosome-related organelles in C. elegans.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

刘易斯与克拉克学院获得了一台台式细胞分选机的奖励，这将促进校园内至少三个实验室的创新和前沿研究。细胞分选是一种根据物理、化学和/或分子特性从异质群体中表征、分离和收集细胞或细胞器的方法。购买细胞分选机将支持生物系为本科生提供有意义的研究经验和生物科学培训。通过扩大校园内可用的方法范围，该工具将扩大刘易斯与克拉克学院的研究能力，并增加本科生在教师研究实验室工作的机会。细胞分选仪也将被纳入实验室课程，即使是入门级的课程，学生将接受培训以设计和开展自己的原创、独立的研究项目。细胞分选在生物研究中变得越来越普遍和必要，因为实验方法的进步以及对研究独特细胞类型和细胞器的更深入的认识。基因组学和蛋白质组学技术现在更加灵敏、高效且经济实惠，为分析通过细胞分选收集的特定细胞和细胞器创造了新的机会。最近的发展也使得基因编辑变得更加容易和容易，最佳实践是使用细胞分选仪来选择基因改变的细胞。因此，细胞分选仪的可用性将支持和推进刘易斯克拉克学院至少三个实验室的研究，以利用这些现代方法获得对生物过程的新见解。其中包括对细胞特异性基因调控机制、尼古丁暴露对黑腹果蝇发育的影响以及线虫中溶酶体相关细胞器功能的研究。该奖项反映了 NSF 的法定使命，并被认为值得支持通过使用基金会的智力优点和更广泛的影响审查标准进行评估。