SBIR Phase I: Viral inactivation in air and on surfaces across large areas by safe, non-thermal, non-ionizing electromagnetic radiation

SBIR 第一阶段：通过安全、非热、非电离电磁辐射灭活空气中和大面积表面上的病毒

• 批准号: 2036664
• 负责人: Luke Raymond
• 金额: $ 25.44万
• 依托单位: AIRITY TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2036664&HistoricalAwards=false
• 关键词: SBIR; Phase; Viral; inactivation; air

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is a new and safe non-contact method and device to inactivate viruses in air or on surfaces and objects. The non-chemical method proposed is scalable and can be quickly adjusted to target novel pathogens and therefore prevent or mitigate future epidemics of novel viral pathogens. The solution enabled by the proposed project is a relatively low-cost portable or ceiling-mounted device to be operated in health care settings, offices, schools, public transit, or other locations where the risk of disease transmission is high. The device would provide a continuous antiviral effect in thousands or millions of locations while operating within safe limits for human exposure. This SBIR Phase I project proposes to validate the concept of a non-contact viral inactivation method that relies on resonant energy transfer from microwaves, and to demonstrate the efficacy in viral assays under operation parameters that are safe for humans and within regulatory guidelines. To accomplish this, a miniaturized and cost-effective high power pulsed microwave source and antenna is required. To this end, a prototype device will be developed that consists of a high-power vacuum electronics device, such as a magnetron or a traveling-wave tube, a custom and novel high voltage power source, and firmware and controls. The power supply will be designed to drive an existing vacuum device, by means of a regulated high-voltage output in the kilowatt range and a floating low-power auxiliary power source. To control pulsed operation, a control algorithm will be implemented in a microcontroller. The prototype will be characterized and used to expose viral samples in common viral growth assays, followed by a quantitative assessment of the antiviral effect. The outcome expected is a functional prototype that achieves significant reduction, e.g., 2 logs, within safe limits that will serve as a blueprint for a novel class of antiviral devices.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小企业创新研究 (SBIR) 项目更广泛的影响/商业潜力是一种新型安全的非接触式方法和设备，可灭活空气中或表面和物体上的病毒。所提出的非化学方法具有可扩展性，可以快速调整以针对新型病原体，从而预防或减轻新型病毒病原体未来的流行。拟议项目提供的解决方案是一种成本相对较低的便携式或吸顶式设备，可在医疗机构、办公室、学校、公共交通或其他疾病传播风险较高的场所运行。该设备将在数千或数百万个地点提供持续的抗病毒作用，同时在人体暴露的安全范围内运行。 该 SBIR 第一阶段项目旨在验证依赖于微波共振能量转移的非接触式病毒灭活方法的概念，并证明在对人类安全且符合监管指南的操作参数下病毒检测的有效性。为了实现这一目标，需要小型化且具有成本效益的高功率脉冲微波源和天线。为此，将开发一种原型设备，该设备由高功率真空电子设备（例如磁控管或行波管）、定制的新型高压电源以及固件和控制器组成。该电源将设计用于通过千瓦范围内的稳压高压输出和浮动低功率辅助电源来驱动现有的真空设备。为了控制脉冲操作，将在微控制器中实施控制算法。该原型将被表征并用于在常见的病毒生长测定中暴露病毒样本，然后对抗病毒效果进行定量评估。预期的结果是一个功能原型，在安全限度内实现显着减少，例如 2 对数，这将作为新型抗病毒设备的蓝图。该奖项反映了 NSF 的法定使命，并通过使用评估被认为值得支持基金会的智力价值和更广泛的影响审查标准。