STTR Phase I: Rapid Acting Disinfectant Spray for Slowing the Spread of COVID-19

STTR 第一阶段：用于减缓 COVID-19 传播的速效消毒喷雾

• 批准号: 2032056
• 负责人: Christina Drake
• 金额: $ 25.55万
• 依托单位: KISMET TECHNOLOGIES Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2032056&HistoricalAwards=false
• 关键词: STTR; Phase; Rapid; Acting; Disinfectant

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is development of a disinfectant spray to curb the transmission of SARS-CoV-2 via contact with contaminated surfaces. COVID-19 transmission occurs primarily via respiratory droplets produced by an infected person and by contact with a surface where a droplet containing the virus exists. Mitigating infection by contact with surfaces is a measure that will slow the spread of novel viruses ahead of development of a vaccine or other protective measures. In conjunction with other measures, a novel disinfectant will support public health during the COVID-19 pandemic. Current disinfectants require times ranging from 30 seconds to 10 minutes for disinfection to begin after application and do not continue to disinfect. The proposed technology creates a temporary, continually disinfecting film that remains on the application surface. This STTR Phase I project will demonstrate both the rapid performance of a novel spray and its ability to form a temporary and continually disinfecting film post=application. This technology employs a select medium containing fast-response doped nanoceria where the oxidizing response/mechanism is engineered to perform several disinfectant reactions in parallel. A safe, rapid, multi-disinfectant approach using engineered nanoceria has not previously been demonstrated for use. The project will also demonstrate the post-application disinfection properties. The goals of this project will be achieved with the following: 1) development of an anti-viral, multi-mechanism disinfectant formulation, 2) demonstration of efficacy and safety, 3) study of product stability, and 4) demonstration of temporary film formation, stability, and activity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小企业技术转让 (STTR) 项目的更广泛影响/商业潜力是开发消毒喷雾剂，以遏制 SARS-CoV-2 通过接触受污染表面进行传播。 COVID-19 传播主要通过感染者产生的呼吸道飞沫以及通过接触含有病毒的飞沫的表面而发生。通过接触表面来减轻感染是一种在疫苗或其他保护措施开发之前减缓新型病毒传播的措施。与其他措施相结合，一种新型消毒剂将在 COVID-19 大流行期间支持公共卫生。目前的消毒剂在使用后需要30秒到10分钟的时间才能开始消毒，并且不能继续消毒。所提出的技术创建了一种临时的、持续消毒的薄膜，保留在应用表面上。 STTR 第一阶段项目将展示新型喷雾剂的快速性能及其在使用后形成临时且持续消毒膜的能力。该技术采用含有快速响应掺杂纳米二氧化钛的精选介质，其中氧化响应/机制被设计为并行执行多个消毒反应。使用工程化纳米陶瓷的安全、快速、多重消毒方法此前尚未得到证实。该项目还将展示应用后的消毒特性。该项目的目标将通过以下方式实现：1）开发抗病毒、多机制消毒剂配方，2）验证功效和安全性，3）研究产品稳定性，以及4）验证临时成膜该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Metal-Mediated Nanoscale Cerium Oxide Inactivates Human Coronavirus and Rhinovirus by Surface Disruption

金属介导的纳米级氧化铈通过表面破坏灭活人类冠状病毒和鼻病毒

• DOI: 10.1021/acsnano.1c04142
• 发表时间: 2021-09
• 期刊: ACS Nano
• 影响因子: 17.1
• 作者: Neal, Craig J.;Fox, Candace R.;Sakthivel, Tamil Selvan;Kumar, Udit;Fu, Yifei;Drake, Christina;Parks, Griffith D.;Seal, Sudipta
• 通讯作者: Seal, Sudipta