SBIR Phase I: Feasibility of Dynamic Configurable Liquid Molding

SBIR 第一阶段：动态可配置液体成型的可行性

• 批准号: 2052113
• 负责人: Eleanor Derbyshire
• 金额: $ 25.6万
• 依托单位: Hummingbird Nano, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2052113&HistoricalAwards=false
• 关键词: SBIR; Phase; Feasibility; Dynamic; Configurable

The broader impact/ commercial potential of this SBIR Phase I project is the creation of a new set of tools for bioscience applications. The innovation has shown promise in benchtop tests to fill a capability gap in manufacturing, and the project will build upon this promise to create 3-dimensional nanoscale fluid pathways. The first target application is to enable widespread use of nanometer-sized particles (30-150 nm) to carry cell signaling information throughout the body. Particles designed to signal a particular cellular response are a major component of drug therapeutics as their size allows them to access parts of the body otherwise impossible to reach, such as the blood-brain barrier in the event of a stroke and tumor penetration for cancer patients. Problematic for these research endeavors is the differentiating these particles from others due to similarity in size (100-300 nm). The innovation could enable these nanoscale entities to traverse nanoscale pathways, resulting in size and physics-based exclusion from other particles. Success in this project aids in promoting the advancement of detection and treatment for global health issues, adding to the general welfare of society, as well as creating a new sector in U.S. bioeconomy.Phase I assesses the feasibility of a potentially disruptive new manufacturing process to create a solid form structure with 3-dimensional pathways, such as helices and sine waves, of circular cross section interior channels for use in micro/nano-fluidics products. The innovation uses the physics of fluid flow to dynamically mold a fluid against a smart fluid, during which process the diameter of the channel being formed can be changed by adjusting the process variables in real-time. The work progresses the knowledge associated with advancing manufacturing capabilities and enables a wide variety of fields based on the products made using the method. For the former, the technology provides a new way to rapidly create fluidic pathways for nano to micro structures, enhancing the understanding of fluidic behaviors, polymerization, smart fluid applications, and creates a new field of study for the dynamic behavior of fluid/fluid molding. The technical goals of the Phase I work use a combination of fluidic modeling and the set-up and execution of a series of experimental tests to demonstrate active control of the channel diameter for 50-500 nm, 3-dimensional structures with controlled diameter channels, and merging and diverging channels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该SBIR I期项目的更广泛的影响/商业潜力是为生物科学应用程序创建了一套新的工具。该创新在台式测试中显示了有望填补制造能力差距的希望，该项目将基于这种有望创建三维纳米级流体途径的承诺。第一个目标应用是能够广泛使用纳米尺寸的颗粒（30-150 nm），以在整个体内携带细胞信号信息。旨在发出特定细胞反应的颗粒是药物治疗剂的主要组成部分，因为它们的大小使它们可以进入身体的一部分，否则无法到达，例如，在癌症患者的中风和肿瘤渗透的情况下，血脑屏障和肿瘤渗透。这些研究努力的问题是，由于大小（100-300 nm）的相似性，这些颗粒与其他粒子的区别。该创新可以使这些纳米级实体能够穿越纳米级途径，从而导致大小和基于物理的排除其他颗粒。该项目的成功有助于促进对全球健康问题的检测和治疗的进步，增加了社会的一般福利，并在美国生物经济学中创建了一个新领域。一I评估了潜在破坏性的新制造过程的可行性，以创建一个固定形式的结构，并在3维途径上创建固定式螺旋 - 螺旋 - 旋转式循环范围，循环范围内的圆形途径，循环范围内的圆形型号，循环范围内的圆形型号，循环范围内的圆形相互作用。 产品。该创新使用流体流的物理学来对智能流体动态塑造流体，在此过程中，可以通过实时调整过程变量来更改所形成的通道的直径。这项工作取得了与推进制造能力相关的知识，并根据使用该方法制造的产品实现了各种各样的领域。对于前者，该技术提供了一种新的方法，可以快速创建纳米到微结构的流体途径，增强对流体行为，聚合，智能流体应用的理解，并为流体/流体成型的动态行为创建新的研究领域。第一阶段工作的技术目标结合使用流畅的建模以及一系列实验测试的设置和执行，以证明对50-500 nm的通道直径的积极控制，具有控制直径渠道的3维结构，受控的直径渠道，以及该奖项的合法性和依据。 标准。