REU Site: Puerto Rico-Chemical Learning Integrated in Materials and Biomolecular applications (PR-CLIMB)

REU 网站：波多黎各化学学习融入材料和生物分子应用 (PR-CLIMB)

• 批准号: 2050493
• 负责人: Arthur Tinoco
• 金额: $ 34.35万
• 依托单位: University of Puerto Rico-Rio Piedras
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2050493&HistoricalAwards=false
• 关键词: REU; Site; Puerto; Rico; Chemical

This Research Experiences for Undergraduates (REU) site award to the University of Puerto Rico-Río Piedras, located in San Juan, PR, supports the training of 10 students for 9 weeks during the summers of 2021-2023. In this program, funded by the Division of Chemistry, undergraduate participants will engage in high caliber interdisciplinary research projects inspired by rebuilding efforts in PR related to the pharmaceutical industry, electrical grid, and water infrastructure. This program also fosters professional development through in-laboratory training, hands-on workshops, and specialized seminars to inspire interest in graduate school in the STEM fields. The broader goal of this site is to train socially conscious scientists who can address community-based problems, to help build the future STEM workforce for Puerto Rico, and to establish a network of STEM professional collaborators. Student participants at this REU site will be matched with research groups conducting fundamental science on the engineering of materials and biomolecules for real-life applications including drug discovery, drug delivery, energy storage, and water purification. The faculty mentors have extensive experience in undergraduate training, and an advanced students or postdoctoral researchers will serve as a co-mentors, providing additional training support to the participants. Alongside research, students will take part in hands-on workshops exposing them to state-of-the-art instrumentation; a seminar series on critical thinking and technical skill development; and orientation on research, graduate school, and career opportunities. A special seminar contextualizes the program’s mission to professionally rehabilitate Puerto Rico, and participants will also go on educational/cultural outings where they will visit a pharmaceutical company and different parts of Puerto Rico. Students majoring in chemistry or related fields are recruited from two-year and four-year institutions in Puerto Rico and the rest of the U.S., particularly from minority serving institutions and from institutions with few research opportunities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该本科生研究体验 (REU) 项目授予位于波多黎各圣胡安的波多黎各大学里奥彼德拉斯分校，支持 2021 年至 2023 年夏季对 10 名学生进行为期 9 周的培训，该项目由以下机构资助。在化学系，本科生参与者将参与高水平的跨学科研究项目，其灵感来自于与制药行业、电网和水基础设施相关的公共关系重建工作。该项目还通过促进专业发展。实验室培训、实践研讨会和专门研讨会，以激发研究生院对 STEM 领域的兴趣。该网站的更广泛目标是培训具有社会意识的科学家，他们能够解决社区问题，帮助建设未来的 STEM。波多黎各的劳动力，并建立一个 STEM 专业合作者网络，该 REU 站点的学生参与者将与研究小组进行匹配，研究小组进行材料和生物分子工程的基础科学，用于现实生活中的应用，包括药物发现、药物输送、能源。储存和水净化。导师在本科生培训方面拥有丰富的经验，高级学生或博士后研究人员将作为共同导师，为参与者提供额外的培训支持，除了研究之外，学生还将参加实践研讨会，让他们接触到最新的情况。先进的仪器；关于批判性思维和技术技能发展的研讨会；以及关于研究、研究生院和职业机会的定向研讨会，该研讨会将介绍该计划的专业复兴波多黎各的使命，参与者还将继续进行教育/文化活动。他们去的郊游将参观一家制药公司和波多黎各的不同地区，从波多黎各和美国其他地区的两年制和四年制院校中招募化学或相关领域的学生，特别是从少数族裔服务机构和少数族裔院校中招募。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Disease-associated non-coding variants alter NKX2-5 DNA-binding affinity.

疾病相关的非编码变异会改变 NKX2-5 DNA 结合亲和力。

• DOI: 10.1016/j.bbagrm.2023.194906
• 发表时间: 2023
• 期刊: Biochimica et biophysica acta. Gene regulatory mechanisms
• 作者: Peña-Martínez,EdwinG;Rivera-Madera,Alejandro;Pomales-Matos,DiegoA;Sanabria-Alberto,Leandro;Rosario-Cañuelas,BrittanyM;Rodríguez-Ríos,JessicaM;Carrasquillo-Dones,EmanuelA;Rodríguez-Martínez,JoséA
• 通讯作者: Rodríguez-Martínez,JoséA