Study on the piezoelectric properties of cancellous bone

松质骨压电特性的研究

基本信息

批准号：
245657515
负责人：
Professorin Dr. Ursula van Rienen
金额：
--
依托单位：
Institut für Allgemeine Elektrotechnik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2014
资助国家：
德国
起止时间：
2013-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/245657515?language=en
关键词：
Study piezoelectric properties cancellous bone

项目摘要

The research project is closely linked with the development of electro-stimulative endoprostheses for the hip joint. The results, however, have a much broader meaning. With a growing aging population, increasingly, revision surgery may be necessary. Often large bone damage is found in the immediate vicinity of the endoprosthesis. Such bone damage may also be caused by disease (eg, bone cancer, damages from alcohol abuse) or accident. In previous work, working closely with colleagues from orthopedics, a first design of an electrode system for a electro-stimulative hip replacement was developed. Although in principle the method of electrical stimulation to enhance bone growth has been known and attained for nearly four decades, many questions still remain open regarding the basic mechanism of action. Furthermore, the empirical stimulation parameters clinically showed to be effective, but it remains unclear whether these are the optimal parameters and how they are exactly related to the physiological processes. Therefore, the goal of this project is to accurately investigate the piezoelectric behavior of bone tissue and to specify appropriate piezoelectric tissue parameters. Here, an experimental test set-up of Fukada and Yasuda, who were the first in 1957 to demonstrate the piezoelectric properties of bone experimentally, will be used and the experiments are reproduced in silico as well. In the simulations, extensive parametric studies are carried out. The resulting tissue parameters should be used in other projects in order to optimize the stimulation parameters previously empirically.

该研究项目与髋关节电刺激内置假体的开发密切相关。然而，结果具有更广泛的意义。随着人口老龄化的不断加剧，修复手术可能越来越有必要。通常在紧邻内置假体的地方发现大的骨损伤。这种骨损伤也可能是由疾病（例如骨癌、酗酒造成的损伤）或事故引起的。在之前的工作中，与骨科同事密切合作，开发了用于电刺激髋关节置换术的电极系统的第一个设计。尽管原则上，电刺激促进骨骼生长的方法已为人所知并已实现了近四十年，但关于其基本作用机制的许多问题仍然悬而未决。此外，经验刺激参数在临床上显示是有效的，但仍不清楚这些是否是最佳参数以及它们与生理过程的确切关系。因此，该项目的目标是准确研究骨组织的压电行为并指定适当的压电组织参数。在这里，将使用 Fukada 和 Yasuda 的实验测试装置，他们于 1957 年首次通过实验证明了骨骼的压电特性，并且实验也在计算机中重现。在模拟中，进行了广泛的参数研究。所得的组织参数应用于其他项目，以便根据经验优化先前的刺激参数。