SBIR Phase I: A Beat-to-Beat Blood Pressure Monitor Using Micro-Nanoscale Wrinkled Functional Materials

SBIR 第一阶段：使用微纳米皱纹功能材料的逐搏血压监测仪

• 批准号: 2036639
• 负责人: Joshua Kim
• 金额: $ 25.6万
• 依托单位: VENA VITALS, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2036639&HistoricalAwards=false
• 关键词: SBIR; Phase; Beat; Blood; Pressure

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project aims to provide medical workers and consumers the utility of continuous blood pressure monitoring with an easy to use adhesive soft sensor, which can greatly improve personalized care and patient outcomes. While a patient is undergoing surgery, blood pressure is monitored because sudden drops have been linked to irreversible tissue and/or organ damage, resulting in post-operative complications and mortality. The traditional arm cuff blood pressure monitor is primarily used in surgical settings but while it is not invasive, the cuff doesn't capture sudden changes in blood pressure. There are more than 50 million surgeries are performed annually, 85% of which rely on non-continuous blood pressure arm cuffs. This project will develop a new wearable medical device to non-invasively and continuously measure beat-to-beat blood pressure. This Small Business Innovation Research Phase 1 project will advance a new device for non-invasive and continuously blood pressure monitoring. Current devices are limited by their accuracy and temporal resolution. The proposed medical device is based on soft wearable pressure sensors that solves the cost, accuracy, and temporal resolution problem. The soft sensor adheres to the body wherever a pulse is palpable and measures the arterial expansion on the surface of the skin as a pulse wave traverses the artery. Soft sensor technology leverages the highly elastic properties of micro-nanostructure wrinkled electronic thin films developed using a novel shrinking fabrication process. Preliminary results using these soft wearable sensors established high correlation to the gold standard arterial line. This project will develop electronics to read and output signals wirelessly from multiple channels as well as highly pressure-sensitive multichannel sensors and a wristband form factor design.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I阶段项目的更广泛的影响/商业潜力旨在为医务人员和消费者提供易于使用的粘合性软传感器的连续血压监测的实用性，这可以大大改善个性化的护理和患者的结果。尽管患者正在接受手术，但由于突然下降与不可逆的组织和/或器官损伤有关，因此监测了血压，导致术后并发症和死亡率。传统的手臂袖口血压监测器主要用于手术环境中，但虽然它不是侵入性的，但袖口并未捕获血压突然变化。每年进行超过5000万次手术，其中85％依赖于非连续血压臂袖口。该项目将开发出一种新的可穿戴医疗设备，以非侵入性地测量Beat-to-Beat血压。这个小型企业创新研究阶段项目将推动一种新设备，用于非侵入性和不断的血压监测。 当前的设备受其准确性和时间分辨率的限制。拟议的医疗设备基于柔软的可穿戴压力传感器，可解决成本，准确性和时间分辨率问题。 软传感器在脉冲可以触及的任何地方都粘附在体内，并随着脉冲波横穿动脉的影响，测量皮肤表面的动脉膨胀。软传感器技术利用了使用新型缩小的制造工艺开发的微纳米结构的高度弹性性能。使用这些柔软可穿戴传感器的初步结果与金标准动脉线建立了高相关性。该项目将开发电子设备，从多个渠道以及高压敏感的多通道传感器和腕带形式构图设计中无线读取和输出信号。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准通过评估来进行评估的。