SBIR Phase I: Viral inactivation in air and on surfaces across large areas by safe, non-thermal, non-ionizing electromagnetic radiation

SBIR 第一阶段：通过安全、非热、非电离电磁辐射灭活空气中和大面积表面上的病毒

• 批准号: 2036664
• 负责人: Luke Raymond
• 金额: $ 25.44万
• 依托单位: AIRITY TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2036664&HistoricalAwards=false
• 关键词: SBIR; Phase; Viral; inactivation; air

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is a new and safe non-contact method and device to inactivate viruses in air or on surfaces and objects. The non-chemical method proposed is scalable and can be quickly adjusted to target novel pathogens and therefore prevent or mitigate future epidemics of novel viral pathogens. The solution enabled by the proposed project is a relatively low-cost portable or ceiling-mounted device to be operated in health care settings, offices, schools, public transit, or other locations where the risk of disease transmission is high. The device would provide a continuous antiviral effect in thousands or millions of locations while operating within safe limits for human exposure. This SBIR Phase I project proposes to validate the concept of a non-contact viral inactivation method that relies on resonant energy transfer from microwaves, and to demonstrate the efficacy in viral assays under operation parameters that are safe for humans and within regulatory guidelines. To accomplish this, a miniaturized and cost-effective high power pulsed microwave source and antenna is required. To this end, a prototype device will be developed that consists of a high-power vacuum electronics device, such as a magnetron or a traveling-wave tube, a custom and novel high voltage power source, and firmware and controls. The power supply will be designed to drive an existing vacuum device, by means of a regulated high-voltage output in the kilowatt range and a floating low-power auxiliary power source. To control pulsed operation, a control algorithm will be implemented in a microcontroller. The prototype will be characterized and used to expose viral samples in common viral growth assays, followed by a quantitative assessment of the antiviral effect. The outcome expected is a functional prototype that achieves significant reduction, e.g., 2 logs, within safe limits that will serve as a blueprint for a novel class of antiviral devices.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）项目的更广泛的影响/商业潜力是一种新的且安全的非接触方法和设备，可在空气或表面和物体上灭活病毒。提出的非化学方法是可扩展的，可以快速调整到靶向新的病原体，从而预防或减轻新型病毒病原体的未来流行病。拟议项目启用的解决方案是一种相对较低的便携式或天花板安装的设备，可在医疗保健环境，办公室，学校，公共交通或其他疾病传播风险很高的地方操作。该设备将在人类暴露的安全限制内运行时，在数千或数百万个位置提供连续的抗病毒效应。 该SBIR I期项目提议验证一种依赖于微波的共振能量转移的非接触式病毒灭活方法的概念，并在操作参数下证明了对人类安全和监管指南中的操作参数下的病毒测定功效。为此，需要一个微型且具有成本效益的高功率脉冲微波源和天线。为此，将开发一种原型设备，该设备由高功效电子设备组成，例如磁控管或旅行波管，定制和新颖的高压电源，以及固件和控制。电源将旨在通过千瓦范围内的受监管的高压输出和浮动的低功率辅助电源来驱动现有的真空设备。为了控制脉冲操作，将在微控制器中实现控制算法。该原型将被表征并用于暴露常见病毒生长测定中的病毒样本，然后对抗病毒药作用进行定量评估。预期的结果是一个功能性原型，可实现显着降低，例如2个日志，在安全的范围内，将作为新型抗病毒设备类别的蓝图。该奖项反映了NSF的法定任务，并被认为是通过基金会的智力优点和广泛的影响来评估Criteria的智力功能和广泛影响。