STTR Phase I: The Coupling of COVID-19 Respiratory Droplet Adsorption and Photocatalysis through Metal Organic Frameworks

STTR 第一阶段：通过金属有机框架耦合 COVID-19 呼吸道飞沫吸附和光催化

• 批准号: 2036542
• 负责人: OSMAN OZDEMIR
• 金额: $ 24.75万
• 依托单位: framergy, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2036542&HistoricalAwards=false
• 关键词: STTR; Phase; Coupling; COVID; 19

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is the prevention of the spread of SARS-CoV-2 (COVID-19) through airborne droplet isolation and destruction. Living in a post-pandemic world means that the virus must be mitigated in our surroundings. The proposed technology offers a method for viral removal and inactivation, and it is expected to offer protection against emergent strains and spread of other future viruses. The proposed technology is already being used to improve the energy efficiency of heating, ventilation and air conditioning (HVAC) systems, which have been shown to be a major concentrators of the virus. The chemistry as a coating can be rapidly applied to any negative air pressure devices, such as masks (respirators and surgical), and air purifiers, making cluster indoor locations safer for inhabitants and workers. The proposed technology can inactivate viruses using visible light, offering cost and safety advantages over ultraviolet (UV) inactivation, as UV is not safe for skin exposure. This STTR project will develop a metal-organic framework (MOF)-based respiratory droplet adsorption coating, which, when activated, will photocatalytically destroy COVID-19 and other airborne contaminants. The project proposes to couple the water adsorptive capacity of nanostructured titanium metal organic frameworks with their photocatalytic oxidation capability to destroy COVID-19 in situ to make indoor spaces safer. The project will advance a coordination polymer-based chemistry which can render COVID-19 inactive through microdroplet isolation and photocatalytic decontamination. Based on their highly tunable priorities and catalytic properties, metal-organic frameworks (MOFs) constitute an effective solution to capture COVID-19 micro-droplets and treat them for their viral content. Preliminary test results have showed that that MOFs can photocatalytically render COVID-19 inactive but there are still stability risks to mitigate. The high valence titanium-based MOFs can address the chemical stability challenges of MOFs, which can eliminate the technical hurdles associated with long term stability, cyclic harvesting of micro-air droplets at low relative humidity and their integration into existing heating, ventilation and air conditioning systems.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小型企业技术转移（STTR）I期项目的更广泛的影响/商业潜力是通过空气寄生的液滴隔离和破坏预防SARS-COV-2（COVID-19）的传播。生活在大流行世界中意味着必须在我们的周围环境中减轻病毒。 拟议的技术提供了一种去除病毒和灭活的方法，预计它将保护对新兴菌株和其他未来病毒的传播提供保护。 提出的技术已经被用来提高加热，通风和空调（HVAC）系统的能源效率，这些系统已被证明是病毒的主要浓度。化学作为涂层可以迅速应用于任何负气压装置，例如口罩（呼吸器和手术）和空气净化器，从而使室内室内位置更安全。 拟议的技术可以使用可见光来使病毒灭活，提供与紫外线（UV）失活的成本和安全优势，因为紫外线对皮肤暴露不安全。 该STTR项目将开发一个基于金属有机框架（MOF）的呼吸液滴吸附涂层，该涂层在激活后将光催化破坏COVID-19和其他空中污染物。 该项目提议将纳米结构的钛金属有机框架的水吸附能力与其光催化氧化能力，以破坏Covid-19的原位，以使室内空间更安全。该项目将推进基于协调的聚合物化学反应，该化学可以通过微滴分离和光催化去污染来使共证于19号。基于其高度可调节的优先级和催化特性，金属有机框架（MOF）构成了捕获Covid-19微滴滴并治疗其病毒含量的有效解决方案。初步测试结果表明，MOF可以光催化呈现COVID-19，但仍然存在缓解稳定的风险。高价钛基的MOF可以解决MOF的化学稳定性挑战，这可以消除与长期稳定性相关的技术障碍，在低相对湿度下以较低的相对湿度的循环收获，以及它们与现有供暖，通风，通风，空调系统的整合，这些奖项通过NSF的范围和空气的奖励进行了评估。 标准。

项目成果

SARS-CoV-2 Inactivation Potential of Metal Organic Framework Induced Photocatalysis

金属有机框架诱导光催化的 SARS-CoV-2 灭活潜力

• DOI: 10.1101/2020.10.01.20204214
• 发表时间: 2020
• 期刊: Medical Archives
• 作者: Ornstein, J;Ozdemir, R;Boehme, A;Nouar, F;Serre, C;Ackerman, D;Herrera, V;Santarpia, J
• 通讯作者: Santarpia, J