SBIR Phase I: Desktop Plug-and-Play Vaporized Hydrogen Peroxide Sterilizers for Personal Protective Equipment (COVID-19)

SBIR 第一阶段：用于个人防护设备的桌面即插即用汽化过氧化氢灭菌器 (COVID-19)

• 批准号: 2033865
• 负责人: Michael Kimble
• 金额: $ 25.6万
• 依托单位: SKYHAVEN SYSTEMS, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2033865&HistoricalAwards=false
• 关键词: SBIR; Phase; Desktop; Plug; Play

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is to enable sterilization of personal protective equipment (PPE). Global response measures to the COVID-19 pandemic have highlighted severe shortages of N95 masks and PPE, which could be alleviated by sterilizing the equipment. This has been demonstrated effectively in large trailers and room-size facilities, but these large units are cost more than $1 M each, require substantive facility modifications, and have strict operational requirements. An alternative approach is to provide desktop sterilizers resembling the ubiquitous steam sterilizers typically used in hospitals and clinical settings. This project will develop a desktop plug-and-play vaporized hydrogen peroxide sterilizer unit to decontaminate PPE within 30 minutes at low cost. These could be deployed throughout a medical facility without requiring substantive room remodeling or restricted access rooms. This SBIR Phase I project proposes to develop and demonstrate a desktop plug-and-play vaporized hydrogen peroxide sterilizer. Vaporized hydrogen peroxide (VHP) is a proven sterilant that exhibits broad-spectrum efficacy against viruses, bacteria, yeasts and bacterial spores. Conventional VHP sterilizers are large units that use concentrated H2O2 cartridges to produce the requisite 750 ppm VHP concentration. Because these units use concentrated H2O2 canisters, the resulting systems have significant process controls and operations to maintain safe operation, design consequences that make it difficult to scale the technology to smaller economical desktop units. Toward producing safer desktop sterilization units, a new chemical reactor will be developed in this program that can produce hydrogen peroxide directly in the vapor state without using hazardous compounds or dangerous reaction conditions. Optimization of the catalysts, reaction area, and operating conditions will be conducted to produce vaporized hydrogen peroxide at concentrations upwards of 750 ppm. Additional components will be developed to safely operate the sterilizer including H2O2 concentration and relative humidity sensors, and a catalytic H2O2 decomposition reactor to breakdown residual H2O2 to water and oxygen. These components will be integrated into a desktop sterilizer unit, along with new control algorithms for safe operation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）项目的更广泛的影响/商业潜力是实现个人保护设备（PPE）的灭菌。 全球对Covid-19大流行的措施强调了N95口罩和PPE的严重短缺，这可以通过对设备进行消毒来缓解。这在大型拖车和室内规模的设施中有效地证明了这一点，但是这些大型单元的成本超过$ 1 m，需要进行实质性的设施修改，并具有严格的操作要求。另一种方法是提供类似于医院和临床环境中通常使用的无处不在的蒸汽灭菌器的台式灭菌器。 该项目将开发一个台式机插入式蒸发过氧化氢灭菌液单元，以低成本在30分钟内净化PPE。 这些可以在整个医疗机构中部署，而无需进行实质性的房间改建或限制访问室。该SBIR I期项目提议开发和演示台式插头蒸发蒸发过氧化氢灭菌剂。蒸发过氧化氢（VHP）是一种经过验证的灭菌剂，对病毒，细菌，酵母菌和细菌孢子具有广谱疗效。常规的VHP灭菌器是使用浓缩H2O2墨盒的大型单位，以产生必要的750 ppm VHP浓度。由于这些单元使用浓缩的H2O2罐，因此所得系统具有重要的过程控制和操作以维持安全的操作，设计后果使得将技术扩展到较小的经济台式机单元。为了生产更安全的桌面灭菌单元，该程序将开发一种新的化学反应器，该反应堆可以直接在蒸气状态下直接产生过氧化氢，而无需使用危险化合物或危险的反应条件。将进行催化剂，反应区域和工作条件的优化，以在750 ppm以上的浓度下产生蒸发过氧化氢。将开发其他组件，以安全地操作灭菌剂，包括H2O2浓度和相对湿度传感器，以及催化H2O2分解反应器，以分解残留的H2O2对水和氧气。 这些组件将集成到桌面灭菌器中，以及用于安全操作的新控制算法。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，认为值得通过评估来获得支持。