RUI: Non-genomic Androgen Receptor Mechanisms Involved in Social Regulation

RUI：参与社会调节的非基因组雄激素受体机制

基本信息

批准号：
2032610
负责人：
Richmond Thompson
金额：
$ 15.08万
依托单位：
Emory University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-24 至 2023-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2032610&HistoricalAwards=false
关键词：
RUI Non genomic Androgen Receptor

项目摘要

Part 1: This research will examine how steroid hormones, which are produced by all vertebrates, directly activate receptors on the surfaces of neurons in the brain to influence behavior. Once activated, these receptors rapidly change the internal responsiveness of those cells to incoming sensory inputs and thus alter an organism's perception of the world around it. Determining if steroids work through such mechanisms will help us better understand basic hormone signaling mechanisms as well as the complex neurochemical processes that enable animals, including humans, to adjust their behavioral responses to constantly changing social environments. The experiments will contribute to the training of our nation's future scientists, educators and doctors through the hands-on research experiences that will be provided for students at an exclusively undergraduate institution. Students will participate in projects related to the award through a lab course run by the PI as well as through focused independent research experiences in the PI's lab. The PIs will recruit students from diverse socioeconomic and racial backgrounds to participate in the research. Additionally, the PI will promote STEM education on a Native American reservation in Maine through a neuroscience workshop.Part 2: Although non-genomic androgen receptor signaling mechanisms have been well-documented in the peripheral tissue of a variety of vertebrates their rapid, central influences have not been thoroughly examined. This project will investigate a novel mechanism through which androgens may rapidly affect social behavior in male goldfish. The goals of this project are to assess whether 1) testosterone rapidly promotes courtship in competitive contexts through androgen receptors; 2) androgen receptors rapidly modulate courtship by influencing responses to pheromones; and 3) androgen receptors affect early olfactory processing and/or functional coupling across brain networks. By characterizing a novel mechanism through which androgens rapidly modulate the processing of social stimuli, new insight into the fundamental neuroendocrine signaling mechanisms that allow animals to rapidly adjust their behavioral responses to constantly changing social environments will be potentially revealed. This project will also have two major types of broader impact. First, it will directly enhance the scientific education of undergraduates at Bowdoin College by integrating the proposed research into an existing neuroscience laboratory course and through independent summer internships and honors projects. Second, the PIs will continue a 4-day workshop in northern Maine for Native American 7th grade students that is built around this project.

第1部分：这项研究将检查所有脊椎动物产生的类固醇激素如何直接激活大脑神经元表面上的受体以影响行为。一旦激活，这些受体会迅速改变这些细胞对传入的感觉输入的内部反应性，从而改变了生物体对周围世界的看法。确定类固醇是否通过这种机制起作用将有助于我们更好地理解基本的激素信号传导机制以及复杂的神经化学过程，这些过程使包括人类在内的动物能够将其行为反应调整为不断变化的社交环境。这些实验将通过动手研究经验为我们国家未来的科学家，教育工作者和医生培训，这些研究经验将为专门的本科机构提供。学生将通过PI运营的实验室课程以及PI实验室中的重点独立研究经验参加与该奖项有关的项目。 PI将招募来自不同社会经济和种族背景的学生参加研究。此外，PI将通过神经科学研讨会促进对缅因州原住民保留的STEM教育。第2部分：尽管在各种脊椎动物的外围组织中已经对非基因组雄激素受体信号传导机制进行了充分的文献，但尚未对其快速，核心影响进行彻底检查。该项目将研究一种新型机制，通过该机制，雄激素可能会迅速影响雄性金鱼的社会行为。该项目的目标是评估1）睾丸激素是否通过雄激素受体迅速促进竞争环境中的求爱； 2）雄激素受体通过影响对信息素的反应来迅速调节求爱； 3）雄激素受体会影响跨大脑网络的早期嗅觉加工和/或功能耦合。通过表征一种新颖的机制，雄激素通过该机制迅速调节了社会刺激的处理，对基本神经内分泌信号传导机制的新见解可能会揭示动物迅速将其行为反应迅速调整到不断变化的社会环境中的行为反应。该项目还将具有两种主要类型的广泛影响。首先，它将直接通过将拟议的研究整合到现有的神经科学实验室课程以及独立的暑期实习和荣誉项目中，从而直接增强鲍登学院的本科生的科学教育。其次，PIS将继续在缅因州北部为美国原住民7年级学生举行的为期4天的研讨会，该研讨会围绕该项目建立。