Impact of the nicotinergic alpha7 receptor on cortical plasticity in smokers and nonsmokers

烟碱能 α7 受体对吸烟者和非吸烟者皮质可塑性的影响

• 批准号: 24408615
• 负责人: Professor Dr. Michael A. Nitsche
• 金额: --
• 依托单位: Klinik für Klinische Neurophysiologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/24408615?language=en
• 关键词: Impact; nicotinergic; alpha7; receptor; cortical

Nicotine is a strong inductor and modulator of cortical activity and long-term potentiation. Hereby it influences learning and memory processes as well as addiction. Nicotine-dependent cognitive improvements in humans seem to differ between smoking and not smoking individuals, as presumed by the deficit compensating hypothesis of nicotine consumption. This project pursues the following aims: (i) First we will differentiate acute cortical excitability shifts elicited by nicotine in smokers and non-smokers (Collaboration with Prof. Wodarz). (ii) We will induce LTPand LTD-like cortical neuroplasticity changes by transcranial direct current stimulation with and without nicotine in smokers and non-smokers, (iii) We will correlate nicotineenhanced neuroplasticity with cognitive performance and performance-related cerebral activity, as revealed by fMRI, in smokers and non-smokers, (iv) The interdependence of neurophysiological and cognitive effects with genetically defined phenotypes (collaboration with Proff. Winterer, Batra, Andreas) of smokers will be explored. In summary, we aim to develop a neurophysiology-based in vivo model of the impact of nicotine on cerebral function, which will help to understand the mechanisms of nicotine addiction and relapse after withdrawal to a greater extent.

尼古丁是皮质活动和长时程增强的强诱导剂和调节剂。因此，它会影响学习和记忆过程以及成瘾。正如尼古丁消费的赤字补偿假说所推测的那样，吸烟者和不吸烟者之间的尼古丁依赖性认知改善似乎有所不同。该项目追求以下目标：（i）首先，我们将区分吸烟者和非吸烟者尼古丁引起的急性皮质兴奋性变化（与 Wodarz 教授合作）。 (ii) 我们将通过在吸烟者和非吸烟者中使用或不使用尼古丁的经颅直流电刺激来诱导 LTP 和 LTD 样皮质神经可塑性变化，(iii) 我们将把尼古丁增强的神经可塑性与认知表现和表现相关的大脑活动联系起来，如fMRI，在吸烟者和非吸烟者中，(iv) 神经生理学和认知效应与遗传定义的表型的相互依赖性（与温特教授、巴特拉、安德烈亚斯）将探讨吸烟者的情况。综上所述，我们的目标是开发一种基于神经生理学的尼古丁对脑功能影响的体内模型，这将有助于更大程度地了解尼古丁成瘾和戒断后复吸的机制。