Bioinspired Sensors for Image Guided Cancer Surgery

用于图像引导癌症手术的仿生传感器

基本信息

批准号：
2030421
负责人：
Viktor Gruev
金额：
$ 60万
依托单位：
University of Illinois at Urbana-Champaign
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2030421&HistoricalAwards=false
关键词：
Bioinspired Sensors Image Guided Cancer

项目摘要

Near-infrared (NIR) fluorescence image-guided surgery (IGS) has shown enormous potential to improve the outcome of cancer surgeries due to the low photon scattering, enabling high signal to background and deeper tissue imaging. The goal of this proposal is to further enhance cancer treatment by decreasing and ideally eliminating, positive tumor margins and small metastatic tumors in first surgeries by simultaneously imaging multiple, small-sized tumor-targeted molecular probes with a novel bioinspired imaging sensor. The project involves understanding how light modulates drug transport across the blood-brain barrier. The results of this project may enable the development of new types of nanoconstructs, which will enable a transformation in the treatment of brain cancer and other types of cancer. The project participants will also work with the St. Louis Science Center to develop a module on the biologically inspired fluorescence sensor. Presentations will be provided to young people during Summer Science Blast summer day camps and museum visitors during Nano Days public fairs. Prof. Gruev and his team are developing a sensor that will identify small tumors and tumor margins during intraoperative settings and present this information to surgeons for complete tumor removal. They will accomplish this by functionally mimicking the visual system of the mantis shrimp—considered the best predator in shallow waters—to develop a single-chip multispectral camera with improved sensitivity and specificity to image several tumor-targeted molecular markers. The project synergistically combines advancements in nanofabrication technology, imaging sensors and tumor targeted molecular markers. They will pre-clinically validate their technology in animal models of breast cancer. The project participants will also work with the St. Louis Science Center to develop a module on the biologically inspired fluorescence sensor. Presentations will be provided to young people during Summer Science Blast summer day camps and museum visitors during Nano Days public fairs. This new imaging technology for cancer surgeries will be incorporated in the curriculum of the new engineering driven medical school at Carle Illinois School of Medicine, training future physicians on emerging technologies for cancer care.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

由于光子散射低，近红外 (NIR) 荧光图像引导手术 (IGS) 已显示出改善癌症手术结果的巨大潜力，可实现背景高信号和更深层次的组织成像。通过使用新型仿生成像传感器同时对多个小型肿瘤靶向分子探针进行成像，减少并理想地消除第一次手术中的阳性肿瘤边缘和小转移性肿瘤，从而增强癌症治疗。该项目涉及了解光如何调节药物在整个手术中的运输。该项目的结果可能有助于开发新型纳米结构，从而实现脑癌和其他类型癌症治疗的转变。项目参与者还将与圣路易斯科学中心合作。 Gruev 教授和他的团队将在 Summer Science Blast 夏令营期间向年轻人和 Nano Days 公共博览会期间的博物馆参观者展示一种基于生物启发的荧光传感器的模块。术中设置和目前的肿瘤边缘他们将通过功能模仿螳螂虾（被认为是浅水中最好的捕食者）的视觉系统来实现这一目标，以开发一种单芯片多光谱相机，其灵敏度和特异性更高，可以对多个肿瘤进行成像。该项目协同结合了纳米制造技术、成像传感器和肿瘤靶向分子标记的进步，他们将在乳腺癌动物模型中验证其技术。科学中心将开发生物启发荧光传感器模块，并将在夏季科学爆炸夏令营期间向年轻人和纳米日公共博览会期间的博物馆参观者提供演示，这种用于癌症手术的新成像技术将纳入该项目的课程中。卡尔伊利诺伊大学医学院的新工程驱动医学院，为未来的医生提供有关癌症治疗新兴技术的培训。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。