Bioinspired Sensors for Image Guided Cancer Surgery

用于图像引导癌症手术的仿生传感器

基本信息

批准号：
2030421
负责人：
Viktor Gruev
金额：
$ 60万
依托单位：
University of Illinois at Urbana-Champaign
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2030421&HistoricalAwards=false
关键词：
Bioinspired Sensors Image Guided Cancer

项目摘要

Near-infrared (NIR) fluorescence image-guided surgery (IGS) has shown enormous potential to improve the outcome of cancer surgeries due to the low photon scattering, enabling high signal to background and deeper tissue imaging. The goal of this proposal is to further enhance cancer treatment by decreasing and ideally eliminating, positive tumor margins and small metastatic tumors in first surgeries by simultaneously imaging multiple, small-sized tumor-targeted molecular probes with a novel bioinspired imaging sensor. The project involves understanding how light modulates drug transport across the blood-brain barrier. The results of this project may enable the development of new types of nanoconstructs, which will enable a transformation in the treatment of brain cancer and other types of cancer. The project participants will also work with the St. Louis Science Center to develop a module on the biologically inspired fluorescence sensor. Presentations will be provided to young people during Summer Science Blast summer day camps and museum visitors during Nano Days public fairs. Prof. Gruev and his team are developing a sensor that will identify small tumors and tumor margins during intraoperative settings and present this information to surgeons for complete tumor removal. They will accomplish this by functionally mimicking the visual system of the mantis shrimp—considered the best predator in shallow waters—to develop a single-chip multispectral camera with improved sensitivity and specificity to image several tumor-targeted molecular markers. The project synergistically combines advancements in nanofabrication technology, imaging sensors and tumor targeted molecular markers. They will pre-clinically validate their technology in animal models of breast cancer. The project participants will also work with the St. Louis Science Center to develop a module on the biologically inspired fluorescence sensor. Presentations will be provided to young people during Summer Science Blast summer day camps and museum visitors during Nano Days public fairs. This new imaging technology for cancer surgeries will be incorporated in the curriculum of the new engineering driven medical school at Carle Illinois School of Medicine, training future physicians on emerging technologies for cancer care.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

近红外（NIR）荧光图像引导的手术（IGS）显示出巨大的潜力，可以改善由于光子散射低而引起的癌症手术结果，从而使高信号能够到背景和更深的组织成像。该提案的目的是通过减少和理想地消除首次手术中的肿瘤缘和小型转移性肿瘤来进一步增强癌症治疗，并通过使用一种新型的生物启动成像传感器来烙印多个，小型肿瘤靶向的分子问题。该项目涉及了解光如何调节横跨血脑屏障的药物运输。该项目的结果可以使新型纳米构造的发展发展，这将使脑癌和其他类型的癌症的治疗进行转化。该项目参与者还将与圣路易斯科学中心合作，在生物学启发的荧光传感器上开发一个模块。在夏季科学爆炸夏季营地和纳米日公共博览会期间，将向年轻人提供演讲。 Gruev教授及其团队正在开发一个传感器，该传感器将在术中环境中识别小肿瘤和肿瘤边缘，并将这些信息呈现给外科医生，以完全清除肿瘤。他们将通过功能地模仿螳螂虾的视觉系统（考虑到浅水中最好的捕食者）来开发具有提高灵敏度和特异性的单芯片多光谱摄像头，以形象形象几个肿瘤标记的分子标记，从而实现这一目标。该项目协同结合了纳米制造技术，成像传感器和靶向分子标记的进步。他们将在乳腺癌动物模型中临时验证其技术。该项目参与者还将与圣路易斯科学中心合作，在生物学启发的荧光传感器上开发一个模块。在夏季科学爆炸夏季营地和纳米日公共博览会期间，将向年轻人提供演讲。这项用于癌症手术的新成像技术将纳入卡尔伊利诺伊州医学院新工程学医学院的课程中，培训未来的医生有关癌症护理的新兴技术。这项奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子的知识和广泛的影响来评估CRITERIA的智力功能。