SBIR Phase I: A Wireless Portable Fully Electronic Hematology Analyzer for Complete Blood Count Analysis

SBIR 第一阶段：用于全血计数分析的无线便携式全电子血液分析仪

• 批准号: 2025773
• 负责人: Jianye Sui
• 金额: $ 25.6万
• 依托单位: RIZLAB HEALTH, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2025773&HistoricalAwards=false
• 关键词: SBIR; Phase; Wireless; Portable; Fully

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop a new device for conducting blood tests at home or in smaller clinical settings. The platform will be fully electronic, portable, low-cost, and using advanced artificial intelligence techniques. This proposed analyzer provides information normally obtained from costly high-end commercial equipment at much lower cost, enabling new diagnosis and monitoring for many different conditions. Additionally, the ultra-compact modules developed here will be applicable to a broad range of assays beyond complete blood count analysis.This Small Business Innovation Research (SBIR) Phase I project seeks to build and characterize an ultra-compact all-electronic cytometer with a fully plastic cartridge capable of quantifying the key cellular components in a complete blood cell count (CBC) test including: red blood cells (RBC), white blood cells (WBC), platelets, hemoglobin (hgb) concentration, and hematocrit levels. An impedance cytometer will be developed in conjunction with machine learning to discriminate between RBCs, WBCs, and platelets, while estimating hgb and hematocrit levels with less than 15 ul of blood. The primary goal is to engineer a cartridge that can work with the reader while being manufacturable in high volume with ultra-low cost. The research will involve fabrication and testing an integrated microfluidic biosensor, developing data-driven software for accurate classification of blood cell types using impedance cytometry data, building ultra-compact pocket-sized hardware and a smartphone application, and finally benchmarking and testing of prototype accuracy against a standard.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I阶段项目的更广泛的影响/商业潜力是开发一种新设备，用于在家中或在较小的临床环境中进行血液检查。该平台将是完全电子，便携式，低成本和使用先进的人工智能技术。 该提出的分析仪通常以较低的成本提供了通常从昂贵的高端商业设备获得的信息，从而实现了许多不同条件的新诊断和监测。此外，此处开发的超紧凑模块将适用于全面血数分析以外的广泛测定法。本小型企业创新研究（SBIR）I期项目旨在构建和表征具有完全塑料弹药术的超压缩的全电细胞计算机，该细胞均能够量化整个细胞的细胞计数（CBB）（CBC）（CBC）（包括：RODB）（包括：RODB）（包括：RODB）。 （WBC），血小板，血红蛋白（HGB）浓度和血细胞比容水平。阻抗细胞仪将与机器学习结合开发，以区分RBC，WBC和血小板，同时估计血液少于15 ul的HGB和血细胞比容水平。主要目标是设计一个可以与读者合作的墨盒，同时以超低成本的大量制造。这项研究将涉及制造和测试集成的微流体生物传感器，开发数据驱动的软件，使用阻抗细胞术数据，构建超紧凑型袖珍式硬件和智能手机应用，并最终根据标准的智能授予的原型奖，并通过标准的奖励进行了对基础的准确性，并以nsf的授权为基础，并以此为基础测试，并构建了智能的准确性。优点和更广泛的影响审查标准。