Genomic Perspectives in Comparative Physiology of Mollusks: Integration across Disciplines

软体动物比较生理学的基因组视角：跨学科整合

• 批准号: 2024684
• 负责人: Maurine Neiman
• 金额: $ 1.49万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2023-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2024684&HistoricalAwards=false
• 关键词: Genomic; Perspectives; Comparative; Physiology; Mollusks; Genomic; Perspectives; Comparative; Physiology; Mollusks

This project will support a symposium, “Genomic Perspectives in Comparative Physiology of Mollusks: Integration across Disciplines” that will take place at The Society of Integrative and Comparative Biology (SICB)'s annual meeting on January 4, 2021 in Washington, D.C, USA. The symposium speakers will all highlight mollusks as a powerful means of linking genome to phenotype - a critical unanswered question in biology. This symposium will bring together a diverse set of biologists from across career stages and institutions and from the biomedical sciences to ecology to address this theme. The symposium activities are designed to encourage engagement and catalyze collaborations. In particular, the symposium will use an interdisciplinary and interactive model that will provide meaningful professional and scientific development opportunities for junior scientists. Mapping genotype to phenotype remains one of the biggest challenges in biology. A mechanistic understanding of the genetic basis of these responses is also critically important to forecast how living systems will respond to rapidly changing environments, which represents an urgent challenge for biologists. This symposium will use an interest in mollusks as a common currency to link biologists in otherwise quite disparate fields (e.g., biomedicine, physiology, ecology). The symposium consists of 11 presentations representing a broad range of efforts to integrate large datasets across levels of biological organization in mollusks, towards the larger goal of linking genome to phenome - one of the Grand Challenges identified by NSF. Presentations, discussions and syntheses will focus on topics that include overviews of the biological and genomic diversity of molluscan life, technological progress towards highly contiguous molluscan genomes, challenges in assembling molluscan genomes, and how genome-scale processes underpin organismal physiology and ecological and evolutionary processes over multiple spatiotemporal scales. Meetings focused on organismal groups traditionally emphasize systematics and taxonomy or the intricacies of organismal biology. The symposium will explicitly take a broader and more integrative perspective, applying new insights and developments from bioinformatics and genomics to solve important biological questions and address health and economic issues that directly impact humans.This award was cofunded by the Integrative Ecological Physiology and the Physiological Mechanisms and Biomechanics Programs in the Division of Integrative Organismal Systems in Directorate for Biological Science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目将支持“软体动物比较生理学中的基因组观点：跨学科的融合”，该研讨会将在2021年1月4日在美国华盛顿特区的综合和比较生物学协会（SICB）举行。专题讨论会的人都将全部强调软体动物是将基因组与表型联系起来的强大手段 - 生物学中的一个关键的未解决的问题。该研讨会将汇集一系列来自职业阶段和机构的生物学家，从生物医学科学到生态学，以解决这一主题。研讨会活动旨在鼓励参与和催化合作。特别是，研讨会将使用跨学科和互动模型，为初级科学家提供有意义的专业和科学发展机会。将基因型映射到表型仍然是生物学中最大的挑战之一。对这些反应的遗传基础的机械理解对于预测生命系统将如何响应快速变化的环境，这对生物学家来说是紧迫的挑战，这也至关重要。该研讨会将对软体动物的兴趣作为一种共同货币，将生物学家在其他不同领域（例如生物医学，生理学，生态学）联系起来。该研讨会由11个演讲组成，代表了整合软体动物生物组织层次跨越大型数据集的广泛努力，以将基因组与现象联系起来的更大目标，这是NSF确定的巨大挑战之一。演讲，讨论和合成将集中在包括软体动物生活的生物学和基因组多样性的概述，朝着高度连续的molluscan基因组方面的技术进步，组装软体素基因组的挑战以及基因组规模过程如何支撑多个量表量表的挑战。传统上着重于有机群体的会议强调系统学和分类法或有机生物学的复杂性。研讨会将明确采用更广泛，更综合的观点，将新见解和发展从生物学信息和基因组学中运用，以解决重要的生物学问题，以解决直接影响人类的健康和经济问题。该奖项是由综合生态生理学的综合生物学机制和生物机械授予的综合生态学机构授予的综合生物学奖，以反映生物力学奖。 NSF的法定使命，并使用基金会的知识分子优点和更广泛的审查标准来评估，被认为是宝贵的支持。