BII-Implementation: GEMS: Genomics and eco-evolution of multi-scale symbioses

BII-实施：GEMS：多尺度共生的基因组学和生态进化

基本信息

批准号：
2022049
负责人：
Katy Heath
金额：
$ 1250万
依托单位：
University of Illinois at Urbana-Champaign
依托单位国家：
美国
项目类别：
Cooperative Agreement
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2022049&HistoricalAwards=false
关键词：
BII Implementation GEMS Genomics eco

项目摘要

Humans, and the animals and plants around them, live in a microbial world. It is now well-known that microbes and viruses infect, interact and move through the genomes of every organism on Earth. Relationships among organisms, and with their microbes, can dramatically change the traits, behaviors, and functions of the host plant or animal. Sometimes these interactions are beneficial and sometimes they can be detrimental by causing disease. Many influence host function and can have hidden but important global scale impacts, driving the rates of responses to climate change, health and disease, antibiotic resistance, and more. Understanding how nested interactions within the microbial world occur and influence our ecosystems is critical to controlling their impact. The new Biology Integration Institute, Genomics and Eco-evolution of Multi-Scale Symbiosis (GEMS), focuses on the classical species interaction between clover and honeybee pollinators as a model to understand the impact and dynamics of the myriad of microbes nested within them. The project takes an integrative approach to understand how molecular interactions impact the ecosystem. As a $20 billion US industry, the outcomes of the project studying clover/honeybee nested genomes has practical value as well as being a model for addressing fundamental questions in integrative biology. The researchers in GEMS are collaborative, diverse, interactive scientists and educators who take an inter-disciplinary approach to answer critical questions about how nested genomes interact and affect the world. The project uses a shared leadership model with co-mentorship between trainer and trainee and multisite educational activities. The established institute is designed to integrate biological disciplines to understand how nested genomes respond to environmental change.GEMS will address the fundamental biological question, How do symbioses unify biology, from molecule to ecosystem? The goal of this project is to establish a framework for how the phenotypic variation generated by the mobility of nested symbionts influences the adaptability of traits and the strength and stability of species interactions. Ultimately, the Institute aims to understand how this variation impacts ecosystem responses to environmental change. The Institute is grounded in the canonical symbiosis between flowering plants and insect pollinators (clover and honeybees), expanding to include interactions nested in their microbial world. The research leverages the extensive knowledge in multiple nested interactions (plant–pollinator, legume–rhizobium, honey bee–microbiome) to build connections within and across systems from the molecular processes that govern establishment of symbiosis and extend phenotypic traits to define how they interact and evolve together in the natural world. Data are integrated with ecological and evolutionary theory to generalize beyond the focal systems to build predictive models. Computer science, statistics, and mathematics expand both the range of biological questions asked and the impact of their answers. Along with the traditional academic silos dividing researchers into molecular and organismal units that prevent a unified view of biology are many others, such as those separating microbe from macrobe, plant from animal, student from faculty, education from research, and diversity, equity, and inclusion from science. Through K-12 education in Spanish and targeting excellence with Project Microbe and the Jim Holland program in three urban and rural communities in the Midwest, GEMS focuses on the intersecting goals of changing how biology is done and who does it, unifying biology by including the small but powerful so often overlooked.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

人类以及周围的动物和植物生活在微生物世界中。现在众所周知，微生物和病毒感染，相互作用并通过地球上每个生物的基因组。生物体及其微生物之间的关系可以大大改变宿主动植物或动物的特征，行为和功能。有时这些相互作用是有益的，有时它们会因疾病而有害。许多人会影响宿主功能，并且可能具有隐藏但重要的全球范围影响，推动了对气候变化，健康和疾病，抗生素抗性的反应率。了解微生物世界中的嵌套相互作用如何发生并影响我们的生态系统对于控制其影响至关重要。新的生物学整合研究所，多尺度共生（GEMS）的生态进化（GEMS）着重于三叶草和蜜蜂授粉媒介之间的经典物种相互作用，因为该项目采用了一种综合方法来了解分子相互作用如何影响生态系统。作为一项耗资200亿美元的美国行业，研究三叶草/蜜蜂嵌套基因组的项目的结果具有实践价值，并且是解决综合生物学基本问题的模型。宝石的研究人员是协作，潜水员，互动科学家和教育者，他们采用跨学科的方法来回答有关嵌套基因组如何相互作用和影响世界的关键问题。该项目使用共享的领导模式，并在培训师和学员之间以及多站点教育活动之间进行会议。既定的研究所旨在整合生物学学科，以了解嵌套基因组对环境变化的反应。GEM将解决基本的生物学问题，符号如何统一从分子到生态系统的生物学统一？该项目的目的是建立一个框架，以实现嵌套符号的移动性产生的表型变化如何影响特征的适应性以及物种相互作用的强度和稳定性。最终，该研究所旨在了解这种变化如何影响生态系统对环境变化的反应。该研究所基于开花植物和昆虫传粉媒介（三叶草和蜜蜂）之间的规范符号，并包括嵌套研究中的相互作用，利用了多种嵌套相互作用的广泛知识他们在自然世界中互动并共同发展。数据与生态和进化论集成在一起，以推广超出焦点系统以构建预测模型。计算机科学，统计和数学既扩大了所提出的生物问题范围及其答案的影响。除传统的学术孤岛将研究人员分为分子和有机单元，从而阻止统一的生物学观点，例如那些将微生物与大物业分开的人，植物与动物的植物，学生与教师，研究，研究，公平性以及多样性，公平性以及与科学的纳入。 Through K-12 education in Spanish and targeting excellence with Project Microbe and the Jim Holland program in three urban and rural communities in the Midwest, GEMS focuses on the intersecting goals of changing how biology is done and who does it, unifying biology by including the small but powerful so often overlooked.This award reflects NSF's statutory mission and has been deemed precious of support through evaluation using the Foundation's intellectual merit and broader impacts审查标准。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Contemporary evolution rivals the effects of rhizobium presence on community and ecosystem properties in experimental mesocosms

当代进化与实验中生态系统中根瘤菌的存在对群落和生态系统特性的影响相媲美

DOI：
10.1007/s00442-022-05253-1
发表时间：
2022
期刊：
Oecologia
影响因子：
2.7
作者：
Lau, Jennifer A.;Hammond, Mark D.;Schmidt, Jennifer E.;Weese, Dylan J.;Yang, Wendy H.;Heath, Katy D.
通讯作者：
Heath, Katy D.

Scaling up and down: movement ecology for microorganisms

放大和缩小：微生物的运动生态学

DOI：
10.1016/j.tim.2022.09.016
发表时间：
2022
期刊：
Trends in Microbiology
影响因子：
15.9
作者：
Wisnoski, Nathan I.;Lennon, Jay T.
通讯作者：
Lennon, Jay T.

Traits of soil bacteria predict plant responses to soil moisture

土壤细菌的特征预测植物对土壤湿度的反应

DOI：
10.1002/ecy.3893
发表时间：
2022
期刊：
Ecology
影响因子：
4.8
作者：
Bolin, Lana G.;Lennon, Jay T.;Lau, Jennifer A.
通讯作者：
Lau, Jennifer A.

Honey bee symbiont buffers larvae against nutritional stress and supplements lysine

DOI：
10.1038/s41396-022-01268-x
发表时间：
2022-06
期刊：
The ISME Journal
影响因子：
0
作者：
Audrey J. Parish;D. W. Rice;Vicki M. Tanquary;Jason M. Tennessen;I. G. Newton
通讯作者：
Audrey J. Parish;D. W. Rice;Vicki M. Tanquary;Jason M. Tennessen;I. G. Newton

Optimal dormancy strategies in fluctuating environments given delays in phenotypic switching

考虑到表型转换延迟的波动环境中的最佳休眠策略