Laser-Cooling-Driven Opto-Thermophoretic Tweezers

激光冷却驱动光热泳镊子

基本信息

  • 批准号:
    2001650
  • 负责人:
  • 金额:
    $ 36万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Optical tweezers won the 2018 Nobel Prize in physics for their applications in biological systems. The tweezers use a highly focused laser beam to trap and manipulate small objects, including cells, particles, bacteria, and virus. Despite the huge success of optical tweezers, the requirement of sophisticated optical setups and high working power prevent their non-invasive manipulation of fragile objects. Tremendous efforts have been made to develop new techniques for optical trapping. However, a universal strategy to safely manipulate different particles and cells in various liquid environments is still elusive. This proposal aims to develop a new optical tweezing platform based on laser cooling and thermal migration of particles in a temperature gradient. Laser cooling can create a localized cold spot on a substrate where various particles can be trapped by thermophoresis. The cooling-induced trapping is expected to effectively avoid the thermal damages due to optical heating in conventional optical tweezer, and the general thermophoretic migration behavior allows this strategy to be used for a wide range of biological cells and nanoparticles to advance life sciences and biomedical applications, including tissue engineering, cellular biology, early disease diagnosis, and drug delivery. The proposed research at the interfaces of physics, photonics, thermo-fluidics, colloidal sciences, and biology will provide interdisciplinary research opportunities for graduate students, undergraduate students, and K-12 students. The outreach efforts will be integrated into two existing Women in Engineering Program initiatives on campus to increase recruiting women and underrepresented minorities into engineering. Opto-thermophoretic tweezers were recently developed as an alternative strategy to manipulate particles and cells in a light-controlled temperature gradient with simple optics and low operation power. However, the current laser-heating-based opto-thermophoretic tweezers suffer from limited applicability to special solvent conditions and potential optothermal damages. The objective of this proposal is to develop and apply new opto-thermophoretic tweezers based on laser cooling of the substrates. Due to the common thermophobia in colloidal species, a variety of biological cells and particles can be trapped at the laser beams via thermophoresis in their native environments. In addition, this design can avoid thermal damages due to the temperature increase in optical tweezers and the heating-based opto-thermophoretic tweezers. The proposed research will provide a novel platform for versatile and non-invasive optical manipulation for nanoparticles and biological cells. The intellectual merit is that the proposed research will improve fundamental understanding of laser cooling and thermophoresis, establish safe optical manipulation techniques for cells in biological media, and advance biological applications of optical tweezers, including studies of cell-cell interactions and thermal cues in cellular behaviors.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
光镊因其在生物系统中的应用而获得2018年诺贝尔物理学奖。镊子使用高度聚焦的激光束来捕获和操纵小物体,包括细胞、颗粒、细菌和病毒。尽管光镊取得了巨大成功,但复杂的光学装置和高工作功率的要求阻碍了它们对易碎物体的非侵入性操作。人们付出了巨大的努力来开发光捕获新技术。然而,在各种液体环境中安全操纵不同颗粒和细胞的通用策略仍然难以实现。该提案旨在开发一种基于激光冷却和温度梯度中粒子热迁移的新型光镊平台。激光冷却可以在基板上产生局部冷点,其中可以通过热泳捕获各种颗粒。冷却诱导捕获有望有效避免传统光镊中光加热造成的热损伤,并且一般的热泳迁移行为使得该策略可用于广泛的生物细胞和纳米粒子,以推进生命科学和生物医学应用,包括组织工程、细胞生物学、早期疾病诊断和药物输送。拟议的物理学、光子学、热流体学、胶体科学和生物学接口研究将为研究生、本科生和 K-12 学生提供跨学科研究机会。外展工作将被纳入校园现有的两项女性工程项目举措中,以增加招募女性和代表性不足的少数族裔进入工程领域。最近开发了光热泳镊子作为一种替代策略,通过简单的光学器件和低操作功率在光控温度梯度下操纵颗粒和细胞。然而,目前基于激光加热的光热泳镊子对特殊溶剂条件的适用性有限,并且存在潜在的光热损伤。该提案的目的是开发和应用基于激光冷却基板的新型光热泳镊子。由于胶体物种普遍耐热,多种生物细胞和颗粒可以在其原生环境中通过热泳被激光束捕获。此外,这种设计可以避免光镊和基于加热的光热泳镊由于温度升高而造成的热损伤。拟议的研究将为纳米粒子和生物细胞的多功能和非侵入性光学操纵提供一个新的平台。其智力价值在于,拟议的研究将提高对激光冷却和热泳的基本理解,为生物介质中的细胞建立安全的光学操纵技术,并推进光镊的生物应用,包括细胞与细胞相互作用和细胞行为中的热线索的研究该奖项反映了 NSF 的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(28)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Synchronous and Fully Steerable Active Particle Systems for Enhanced Mimicking of Collective Motion in Nature
用于增强模拟自然界集体运动的同步且完全可操纵的主动粒子系统
  • DOI:
    10.1002/adma.202304759
  • 发表时间:
    2023-12
  • 期刊:
  • 影响因子:
    29.4
  • 作者:
    Chen, Zhihan;Ding, Hongru;Kollipara, Pavana Siddhartha;Li, Jingang;Zheng, Yuebing
  • 通讯作者:
    Zheng, Yuebing
Sensitivity‐Enhancing Strategies in Optical Biosensing
光学生物传感的灵敏度增强策略
  • DOI:
    10.1002/smll.202004988
  • 发表时间:
    2020-12
  • 期刊:
  • 影响因子:
    13.3
  • 作者:
    Kim, Youngsun;Gonzales, John;Zheng, Yuebing
  • 通讯作者:
    Zheng, Yuebing
Plasmonic Nanotweezers and Nanosensors for Point‐of‐Care Applications
用于定点护理应用的等离子纳米镊子和纳米传感器
  • DOI:
    10.1002/adom.202100050
  • 发表时间:
    2021-04-17
  • 期刊:
  • 影响因子:
    9
  • 作者:
    Xiaolei Peng;Abhay Kotnala;B. Rajeeva;Mingsong Wang;Kan Yao;Neel Bhatt;Daniel Penley;Yuebing Zheng
  • 通讯作者:
    Yuebing Zheng
Detection and analysis of chiral molecules as disease biomarkers
作为疾病生物标志物的手性分子的检测和分析
  • DOI:
    10.1038/s41570-023-00476-z
  • 发表时间:
    2023-03-20
  • 期刊:
  • 影响因子:
    36.3
  • 作者:
    Yaoran Liu;Zilong Wu;D. Armstrong;Herman Wolosker;Yuebing Zheng
  • 通讯作者:
    Yuebing Zheng
Broadband Forward Light Scattering by Architectural Design of Core–Shell Silicon Particles
通过核壳硅粒子的结构设计实现宽带前向光散射
  • DOI:
    10.1002/adfm.202100915
  • 发表时间:
    2021-02
  • 期刊:
  • 影响因子:
    19
  • 作者:
    De Marco, Maria Letizia;Jiang, Taizhi;Fang, Jie;Lacomme, Sabrina;Zheng, Yuebing;Baron, Alexandre;Korgel, Brian A.;Barois, Philippe;Drisko, Glenna L.;Aymonier, Cyril
  • 通讯作者:
    Aymonier, Cyril
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Yuebing Zheng其他文献

Active plasmonic devices based on ordered Au nanodisk arrays
基于有序金纳米盘阵列的主动等离子体装置
Digital Assembly of Colloidal Particles for Nanoscale Manufacturing
用于纳米级制造的胶体颗粒的数字组装
Optothermal Manipulation at Fluid Interfaces
流体界面的光热操纵
Room‐Temperature Observation of Near‐Intrinsic Exciton Linewidth in Monolayer WS2 (Adv. Mater. 15/2022)
单层 WS2 中近本征激子线宽的室温观察(Adv. Mater. 15/2022)
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jie Fang;Kan Yao;Tianyi Zhang;Mingsong Wang;Taizhi Jiang;Suichu Huang;B. Korgel;M. Terrones;A. Alú;Yuebing Zheng
  • 通讯作者:
    Yuebing Zheng
Symmetric and isotropic micro/nanorotors driven by a plane-polarized gaussian laser beam
由平面偏振高斯激光束驱动的对称和各向同性微/纳米转子
  • DOI:
    10.1117/12.2593464
  • 发表时间:
    2021-08-01
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Hongru Ding;P. Kollipara;Abhay Kotnala;Zhihan Chen;Yuebing Zheng
  • 通讯作者:
    Yuebing Zheng

Yuebing Zheng的其他文献

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{{ truncateString('Yuebing Zheng', 18)}}的其他基金

PFI-TT: Development of a Bubble Printer for Low-cost, Rapid Fabrication of High-Resolution Displays
PFI-TT:开发用于低成本、快速制造高分辨率显示器的气泡打印机
  • 批准号:
    2140985
  • 财政年份:
    2022
  • 资助金额:
    $ 36万
  • 项目类别:
    Standard Grant
I-Corps: Bubble printing of colloidal nanoparticles for commercial display and other applications
I-Corps:用于商业显示和其他应用的胶体纳米粒子的气泡印刷
  • 批准号:
    2146871
  • 财政年份:
    2021
  • 资助金额:
    $ 36万
  • 项目类别:
    Standard Grant
Bubble-printing of Colloidal Nanoparticles into Functional Materials and Devices
将胶体纳米粒子气泡印刷成功能材料和器件
  • 批准号:
    1761743
  • 财政年份:
    2018
  • 资助金额:
    $ 36万
  • 项目类别:
    Standard Grant
Enhanced Efficiency in Transparent Organic Photovoltaics Using Oxide Plasmonic Nanostructures
使用氧化物等离子体纳米结构提高透明有机光伏的效率
  • 批准号:
    1704634
  • 财政年份:
    2017
  • 资助金额:
    $ 36万
  • 项目类别:
    Standard Grant

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基于自驱动液滴弹跳的芯片热点冷却热质传输机理与调控
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Optimization of Thermally Driven Building Cooling Systems
热驱动建筑冷却系统的优化
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  • 批准号:
    19K21926
  • 财政年份:
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  • 批准号:
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CO2减少驱动中新世晚期全球变冷的机制
  • 批准号:
    26287129
  • 财政年份:
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使用液体干燥剂由太阳能/废热驱动的除湿和冷却
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