Doctoral Dissertation Research: The phenotypic consequences of adaptive introgression in naturally hybridizing primates

博士论文研究：自然杂交灵长类动物适应性渐渗的表型后果

• 批准号: 2018897
• 负责人: Jenny Tung
• 金额: $ 3.22万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018897&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Research; phenotypic; consequences

Recent findings suggest that intermixing with now-extinct relatives like the Neanderthals may have helped humans adapt to new environments during their rapid expansion around the globe, and may still contribute to human differences in disease susceptibility today. However, the extent to which benefits to hybridization are also found in other primates is not well understood. This doctoral dissertation project will use a model for natural hybridization in primates to investigate signatures of beneficial transfer of genetic variants between species. It will also ask whether hybridization affects hair color and maturation timing in baboons, traits that may be important in mate competition, fertility, or survival. The research will provide novel insight into hybridization’s role in primate evolution and shed light on how hybridization may influence primate diversity in the future. It will also contribute to STEM education at the elementary, undergraduate, and graduate levels through the design of new educational activities, mentored research opportunities for undergraduate students, and support for the co-PI’s PhD training. Finally, this project will facilitate public engagement with science through free-to-the-public presentations that will also be accessible online.To investigate the potential benefits of hybridization in primates, the project will integrate genomic and observational data from wild baboons. It will test the hypothesis that hybridization facilitates the transfer of a small number of advantageous genetic variants between yellow baboons and anubis baboons. To do so, genomic data will be generated for multiple populations spanning a baboon hybrid zone. These data will be subjected to three complementary methods to identify genetic variants affected by adaptive introgression. Cases of potential adaptive introgression will be investigated for overlap with genes that are also differentially expressed between yellow and anubis baboons. The project also will test the hypothesis that genetic ancestry predicts hair color and maturation timing in a well-studied baboon population at the center of the hybrid zone. It will assess whether ancestry effects on these traits differ in number and magnitude across the genome, based on evidence that hair and skin color traits tend to have a simpler genetic basis than life history traits like maturation timing. Finally, the project will test whether regions in the genome that contribute to ancestry-related differences in hair color or maturation timing are candidates for adaptive introgression.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

最近的发现表明，与尼安德特人（Neanderthals）这样的现在灭绝的亲戚的混合可能有助于人类在全球迅速扩张期间适应新的环境，并且仍可能导致当今疾病易感性的人类差异。但是，在其他元素中也发现了在杂交中的益处的程度尚不清楚。该博士学位论文项目将使用主要的主要杂交模型来研究物种之间遗传变异的有益转移的特征。它还将询问杂交是否会影响狒狒的头发颜色和成熟时机，在伴侣竞争，生育能力或生存中可能很重要的特征。这项研究将为杂交在灵长类动物进化中的作用提供新的见解，并阐明杂交如何影响未来的灵长类动物多样性。它还将通过设计新的教育活动，为本科生提供研究机会，并支持Co-Pi的博士学位培训，从而为小学，本科和研究生级别的STEM教育做出贡献。最后，该项目将通过自由到公共的演讲促进公众与科学的参与，这些演讲也将在线访问。为了调查私人杂交的潜在益处，该项目将整合野生狒狒的基因组和观察数据。它将检验以下假设，即杂交有助于在黄狒狒和阿努比斯狒狒之间转移少量有利的遗传变异。为此，将为跨狒狒混合区域的多个种群生成基因组数据。这些数据将采用三种完整的方法，以识别受自适应渗入影响的遗传变异。将研究潜在的适应性渗入病例，以与黄色和阿努比斯狒狒之间也不同表达的基因重叠。该项目还将检验以下假设：遗传血统预测杂种区中心的狒狒种群中的头发颜色和成熟时间。它将根据证据表明，头发和肤色特征倾向于比成熟时期（如成熟时期）具有更简单的遗传基础，它将评估祖先对这些特征的影响是否在整个基因组中的数量和幅度不同。最后，该项目将测试基因组中与祖先相关的头发颜色或成熟时间差异的差异是否是适应性渗入的候选者。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的审查标准来通过评估而被认为是珍贵的支持。

项目成果

Ecology and age, but not genetic ancestry, predict fetal loss in a wild baboon hybrid zone

• DOI: 10.1002/ajpa.24686
• 发表时间: 2023-01-09
• 期刊: AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY
• 作者: Fogel，Arielle S.;Oduor，Peter O.;Tung，Jenny
• 通讯作者: Tung，Jenny