MRI: acquisition of a gas chromatograph isotope ratio mass spectrometer for compound-specific isotope analysis

MRI：获取气相色谱同位素比质谱仪用于化合物特异性同位素分析

• 批准号: 2018078
• 负责人: Tripti Bhattacharya
• 金额: $ 30.21万
• 依托单位: Syracuse University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018078&HistoricalAwards=false
• 关键词: MRI; acquisition; gas; chromatograph; isotope

This award supports the acquisition of a gas chromatograph coupled to an isotope-ratio mass spectrometer (GC-IRMS) at Syracuse University (SU). GC-IRMS systems permit the analysis of stable isotopic ratios of hydrogen, carbon, and nitrogen in particular classes of organic materials ranging from waxes to amino acids to synthetic organic compounds. By isolating the isotopic signature of a single compound type with known pathways of synthesis, deposition, and degradation, GC-IRMS instrumentation allows us to link isotopic signals to particular chemical, physical, or biological processes. This instrument will therefore enable a broad group of users at SU to generate data that addresses questions of pressing social importance in a variety of fields. For instance, hydrogen isotopic analyses of lipid compounds produced by terrestrial plants can quantify paleoclimatic changes in rainfall. These data can then be used to evaluate the skill of climate models and hone our understanding of the reliability of future projections from these models. Analysis of nitrogen and carbon isotopes in amino acids also have the potential to advance our understanding of ocean ecosystem responses to both past and current global change. The instrument also serves an important educational function, providing undergraduate and graduate students with training in laboratory and analytical skills directly transferrable to STEM careers. Additionally, the GC-IRMS will support ongoing efforts to create summer internship opportunities for underserved K-12 and community college students, providing direct exposure to future career pathways in STEM fields. GC-IRMS techniques combine the chromatographic resolution provided through GC with the precise isotopic measurements provided by mass spectrometry. This type of instrumentation will support ongoing NSF-funded research in paleoclimatology, ecology, and biogeochemistry. For instance, the presence of a GC-IRMS at SU will enable hydrogen isotopic analyses of terrestrial leaf waxes, which will be used to reconstruct monsoon dynamics during past warm intervals in Earth history. Moreeover, nitrogen and carbon isotopic analyses of baleen and carbonate shell-bound organic matter will support reconstructions of trophic webs in marine ecosystems. Additional users at SU and affiliated institutions will use compound-specific isotopic methods to interrogate the controls on the growth of freshwater microbialites, the transformation of pollutants in fluvial systems, and the structure and function of multi-trophic interactions in terrestrial ecosystems. The GC-IRMS therefore fulfills a major gap in research infrastructure at Syracuse University and will support the continuation as well as the growth of cutting-edge research across a variety of disciplines of Earth Sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项支持收购锡拉丘兹大学（SU）的同位素比率质谱仪（GC-IRMS）的气相色谱仪。 GC-IRMS系统允许分析从蜡到氨基酸到合成有机化合物的特定类型有机材料的稳定同位素比。通过隔离具有已知合成，沉积和降解途径的单个化合物的同位素特征，GC-IRNS仪器使我们能够将同位素信号与特定的化学，物理或生物学过程联系起来。因此，该工具将使SU的大量用户能够生成数据，以解决在各个领域中紧迫社会重要性的问题。例如，陆生植物产生的脂质化合物的氢同位素分析可以量化降雨中古气候变化。然后，这些数据可用于评估气候模型的技能，并磨练我们对这些模型未来预测的可靠性的理解。对氨基酸中氮和碳同位素的分析也有可能提高我们对海洋生态系统对过去和当前全球变化的反应的理解。该乐器还发挥了重要的教育功能，为本科生和研究生提供了可直接转移到STEM职业的实验室和分析技能培训。此外，GC-IRMS将支持正在进行的努力为服务不足的K-12和社区大学生创造暑期实习机会，从而直接接触STEM领域的未来职业道路。 GC-IRMS技术将通过GC提供的色谱分辨率与质谱法提供的精确同位素测量结合在一起。这种类型的仪器将支持正在进行的NSF资助的古气候，生态学和生物地球化学研究。例如，SU处的GC-Irms的存在将实现陆生叶蜡的氢同位素分析，该分析将用于在过去的地球历史上的过去温暖的间隔内重建季风动力学。更重要的是，对Baleen和碳酸盐壳结合的有机物的氮和碳同位素分析将支持海洋生态系统中营养网的重建。 SU和附属机构的其他用户将使用复合特异性同位素方法来询问有关淡水微生物生长的控制，河流系统中污染物的转化以及地层生态系统中多营养相互作用的结构和功能。因此，GC-Irms在锡拉丘兹大学（Syracuse University）的研究基础架构方面存在重大差距，并将支持延续以及跨地球科学学科的尖端研究的增长。这一奖项反映了NSF的法定任务，并被认为是通过基金会的知识优点和广泛影响的评估来评估，并被认为是值得的支持。

项目成果

Expansion and Intensification of the North American Monsoon During the Pliocene

• DOI: 10.1029/2022av000757
• 发表时间: 2022-11
• 期刊: AGU Advances
• 影响因子: 8.4
• 作者: Tripti Bhattacharya;R. Feng;J. Tierney;Claire B. Rubbelke;N. Burls;Scott Knapp;M. Fu