REU Site: Biological Adaptations to Stress - Molecular, Cellular, Ecological

REU 网站：生物对压力的适应 - 分子、细胞、生态

• 批准号: 1950350
• 负责人: Jay Brewster
• 金额: $ 30.82万
• 依托单位: Pepperdine University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1950350&HistoricalAwards=false
• 关键词: REU; Site; Biological; Adaptations; Stress

This REU Site award to Pepperdine University, located in Malibu, CA, will support the training of 8 students for 11 weeks during the summers of 2020-2022. Over three years of the award, the program will train a total of 24 students, recruited primarily from schools with limited research opportunities and from underrepresented populations. The program focuses on biological adaptations to stress, and includes projects in cell biology, plant biology, mathematical modeling of biological systems, ecology, and microbiology. Through direct mentoring by faculty, students develop their own independent project questions emerging from a review of the current research literature. Students will engage in authentic and relevant research, with a goal to contribute scholarly findings to the research literature. All REU students will have access to state-of-the-art research infrastructure on the Pepperdine campus. Program success will be assessed using a common web-based assessment tool used by all REU programs (SALG URSSA), as well as specific tools developed within the Pepperdine program. Upon completion of the program, many students will present their research findings at local and national conferences. Students will be tracked after the program in order to determine their career paths. The Pepperdine REU program focuses on the biological adaptation to stress. Projects vary by discipline, but include ecological/genetic studies in the Santa Monica Mountains and Pacific Ocean adjacent to the Pepperdine campus, cellular and biochemical studies of the consequences of environmental toxins, mathematical modeling of biological systems, and the impact of environmental stress upon soil microbial diversity. The program specific aims are to: 1) enhance the maturation of undergraduate students as young scientists; 2) engage students in full-time, authentic biological research and the effective communication of research findings; 3) introduce students to bioinformatics and mathematical modeling; 4) train students to engage non-scientists and the public through service and clear communication; and 5) provide research opportunities for students from underrepresented groups and from schools that lack research opportunities. For more information about the program, students can visit the website (https://seaver.pepperdine.edu/surb/) where they can apply online. In addition, students can contact the PI (Dr. Jay Brewster at [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

REU 授予位于加利福尼亚州马里布的佩珀代因大学的场地奖励将支持 8 名学生在 2020-2022 年夏季进行为期 11 周的培训。在该奖项的三年内，该项目将培训总共 24 名学生，这些学生主要从研究机会有限的学校和代表性不足的人群中招募。该项目的重点是生物对压力的适应，包括细胞生物学、植物生物学、生物系统数学模型、生态学和微生物学方面的项目。通过教师的直接指导，学生通过回顾当前的研究文献来开发自己的独立项目问题。学生将从事真实且相关的研究，目标是为研究文献贡献学术成果。所有 REU 学生都可以使用佩珀代因校区最先进的研究基础设施。计划的成功将使用所有 REU 计划使用的通用网络评估工具 (SALG URSSA) 以及佩珀代因计划内开发的特定工具进行评估。该计划完成后，许多学生将在地方和国家会议上展示他们的研究成果。项目结束后将对学生进行跟踪，以确定他们的职业道路。 佩珀代因 REU 项目的重点是生物对压力的适应。项目因学科而异，但包括佩珀代因校区附近的圣莫尼卡山脉和太平洋的生态/遗传学研究、环境毒素后果的细胞和生化研究、生物系统的数学建模以及环境压力对土壤的影响微生物多样性。该计划的具体目标是：1）促进本科生作为年轻科学家的成熟； 2）让学生参与全日制、真实的生物学研究以及研究成果的有效传播； 3）向学生介绍生物信息学和数学建模； 4）培训学生通过服务和清晰的沟通与非科学家和公众互动； 5) 为代表性不足的群体和缺乏研究机会的学校的学生提供研究机会。有关该计划的更多信息，学生可以访问网站 (https://seaver.pepperdine.edu/surb/)，在那里他们可以在线申请。 此外，学生可以联系 PI（Jay Brewster 博士，[e-mail]）。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Climatic stress decreases tick survival but increases rate of host‐seeking behavior

气候压力会降低蜱的存活率，但会增加寻找寄主的行为

• DOI: 10.1002/ecs2.4369
• 发表时间: 2023-01
• 期刊: Ecosphere
• 影响因子: 2.7
• 作者: Nielebeck, Caleb;Kim, Sang Hyo;Pepe, Antonio;Himes, Lucian;Miller, Zachary;Zummo, Sophia;Tang, Mary;Monzón, Javier D.
• 通讯作者: Monzón, Javier D.

Composition and Functional Potential of the Human Mammary Microbiota Prior to and Following Breast Tumor Diagnosis

乳腺肿瘤诊断前后人类乳腺微生物群的组成和功能潜力

• DOI: 10.1128/msystems.01489-21
• 发表时间: 2022-06-28
• 期刊: mSystems
• 影响因子: 6.4
• 作者: Hoskinson, Courtney;Zheng, Kelly;Gabel, Jaelyn;Kump, Annie;German, Rana;Podicheti, Ram;Marino, Natascia;Stiemsma, Leah T.
• 通讯作者: Stiemsma, Leah T.

A novel laboratory method to simulate climatic stress with successful application to experiments with medically relevant ticks

一种模拟气候应激的新型实验室方法，并成功应用于医学相关蜱虫实验

• DOI: 10.1371/journal.pone.0275314
• 发表时间: 2022
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Nielebeck, Caleb;Kim, Sang Hyo;Dedmon, Lauren;Pangilinan, Mark;Quan, Jahred;Ota, William;Monzón, Javier D.
• 通讯作者: Monzón, Javier D.