SBIR Phase I: Development and commercialization of organic photocatalysts for light-driven C-N cross-coupling reaction

SBIR 第一阶段：用于光驱动 C-N 交叉偶联反应的有机光催化剂的开发和商业化

• 批准号: 1947053
• 负责人: Chern-Hooi Lim
• 金额: $ 22.5万
• 依托单位: New Iridium
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1947053&HistoricalAwards=false
• 关键词: SBIR; Phase; Development; commercialization; organic

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is to develop special metal-free catalysts to dramatically reduce chemical manufacturing costs. In addition, these catalysts significantly expand the range of light-driven reactions, leading to profound advancements in pharmaceuticals, healthcare, agriculture, biology, material science, and other industries. Because light-driven chemical technology predominantly relies on scarce and expensive precious metal catalysts, it is limited today to small-scale R&D applications only. At scale, light-driven technology using metal-free catalysts can greatly reduce chemical manufacturing costs by replacing conventional reactions that rely on expensive precious metals, which are also limited to specific classes of reactions. This new chemistry will significantly expand the possibilities for applications of light-driven chemical technology, leading to novel products and greater consumer access through lower costs.This Small Business Innovation Research (SBIR) Phase I project proposes to demonstrate the suitability of metal-free (organic) photoredox catalysts (PCs) in challenging and important pharmaceutical reactions. Organic PCs are key enablers of photoredox catalysis, an emerging field of chemistry gaining significant traction in drug development. Driven by light absorption, photoredox catalysis offers significant advantages over conventional heat-driven methods (e.g. Pd catalysis), including cost, ease of use, and broadened fields-of-use. Importantly, organic PCs are sustainable and scalable alternatives to predominantly used precious metal PCs, allowing photoredox catalysis to extend to full industrial use, including drug manufacturing. To spur industrial adoption of photoredox catalysis, research objectives include proving feasibility of organic PCs in medicinally important reactions, while expanding substrate scope to include biologically relevant and highly functionalized substrates typically used in drug designs. Photoredox-catalyzed reactions powered by organic PCs will access new chemistries beyond capabilities of conventional heat-driven catalysis. In addition, guided by quantum simulations, new high-performance organic PCs will be developed with unique properties beyond those reported in the literature, unlocking new transformations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小企业创新研究 (SBIR) 项目更广泛的影响/商业潜力是开发特殊的无金属催化剂，以大幅降低化学品制造成本。此外，这些催化剂显着扩大了光驱动反应的范围，从而在制药、医疗保健、农业、生物学、材料科学和其他行业取得了深刻的进步。由于光驱动化学技术主要依赖于稀缺且昂贵的贵金属催化剂，因此目前仅限于小规模研发应用。从规模上看，使用无金属催化剂的光驱动技术可以通过取代依赖昂贵贵金属的传统反应来大大降低化学制造成本，而这些传统反应也仅限于特定类别的反应。这种新的化学物质将显着扩大光驱动化学技术应用的可能性，从而通过降低成本带来新颖的产品和更多的消费者机会。这个小型企业创新研究（SBIR）第一阶段项目旨在证明无金属（有机）光氧化还原催化剂（PC）在具有挑战性和重要的制药反应中的应用。有机PC是光氧化还原催化的关键推动者，光氧化还原催化是一个新兴的化学领域，在药物开发中获得了巨大的关注。在光吸收驱动下，光氧化还原催化比传统的热驱动方法（例如钯催化）具有显着优势，包括成本、易用性和更广泛的使用领域。重要的是，有机 PC 是主要使用的贵金属 PC 的可持续且可扩展的替代品，使光氧化还原催化扩展到整个工业用途，包括药物制造。为了促进光氧化还原催化的工业应用，研究目标包括证明有机PC在医学上重要反应中的可行性，同时扩大底物范围以包括药物设计中通常使用的生物相关和高度功能化的底物。由有机PC驱动的光氧化还原催化反应将获得超越传统热驱动催化能力的新化学物质。此外，在量子模拟的指导下，将开发出具有超越文献报道的独特性能的新型高性能有机PC，从而开启新的变革。该奖项反映了NSF的法定使命，并通过使用基金会的智力评估进行评估，被认为值得支持。优点和更广泛的影响审查标准。