CAREER: CAS: Radical Cascade-Driven Polymerization and Depolymerization

职业：CAS：自由基级联驱动的聚合和解聚

• 批准号: 1944512
• 负责人: Jia Niu
• 金额: $ 67.5万
• 依托单位: Boston College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1944512&HistoricalAwards=false
• 关键词: CAREER; CAS; Radical; Cascade; Driven

With this CAREER Award from the Macromolecular, Supramolecular and Nanochemistry Program in the Chemistry Division, Professor Jia Niu at Boston College is designs and develops new techniques for the synthesis and degradation of plastics. The method uses highly reactive molecules and catalysts based on copper, ruthenium, and iridium. Professor Niu's research is also using computational methods to better understand how these reactions work and how to improve them. Ring-opening and ring-closing polymerization reactions provide unique benefits in sustainability because of their ability use environmentally-friendly building blocks and degrade under mild conditions. This research has the potential to develop next-generation materials that are used in temperature-stable soft matter, stimuli-responsive materials, and targeted drug delivery. The project contributes to the training of a diverse group of students in a highly interdisciplinary research environment. The undergraduate course “Design Your Own Pet-RAFT” trains undergraduate students in a laboratory setting. Professor Niu also implements outreach activities centered on the minicourse “Polymers and You." This course is designed for 6th-9th grade urban homeless children in the greater Boston area.This research is focused on developing a new strategy for polymer synthesis that employs radical cascade reactions that provide the key driving force for the controlled synthesis of polymers and stimuli-triggered degradation of precision main-chain polymers. There are three main objectives associated with the project. The first objective focuses on structure-function relationships in radical ring opening polymerizations and couples experimental and computational techniques aimed at optimization of several important reaction parameters. In the second objective, polymers featuring gamma-lactams in the main backbone are prepared using ring-closing cascade polymerization. The last aim concentrates on the synthesis of self-immolative polymers via step-growth and ring-opening metathesis polymerizations techniques. Research associated with this award enables the synthesis of macromolecules that contain functional groups in the main backbone, rather than side chains which is the traditional approach associated with other polymerization techniques. The research is highly transformative and it could lead to a new exciting platform for industrially-relevant controlled radical polymerizations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

波士顿学院的牛佳教授获得了化学系高分子、超分子和纳米化学项目的职业奖，他正在设计和开发塑料合成和降解的新技术，该方法使用基于铜、钌的高反应性分子和催化剂。和铱教授的研究还利用计算方法来更好地了解这些反应如何进行以及如何改进它们的开环和闭环聚合反应。由于它们能够使用环保的构件并在温和的条件下降解，因此具有可持续性的好处。这项研究有潜力开发用于温度稳定的软物质、刺激响应材料和靶向药物输送的下一代材料。该项目致力于在高度跨学科的研究环境中培养多元化的学生群体，本科生课程“Design Your Own Pet-RAFT”在实验室环境中对本科生进行培训，牛教授还开展了以迷你课程“聚合物”为中心的推广活动。和你。”本课程是为大波士顿地区六至九年级的城市无家可归儿童设计的。这项研究的重点是开发一种新的聚合物合成策略，该策略采用自由基级联反应，为聚合物的受控合成提供关键驱动力该项目有三个主要目标，即自由基开环聚合中的结构-功能关系，以及旨在优化几个重要反应参数的实验和计算技术。在第二个目标中，以γ-内酰胺为主链的聚合物是通过闭环级联聚合制备的，最后一个目标集中于通过逐步增长和开环复分解聚合技术合成自消聚合物。该研究具有高度变革性，可能会带来一个新的令人兴奋的平台。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Quantitative, Regiospecific, and Stereoselective Radical Ring-Opening Polymerization of Monosaccharide Cyclic Ketene Acetals

单糖环状乙烯酮缩醛的定量、区域特异性和立体选择性自由基开环聚合

• DOI: 10.1021/jacs.3c14244
• 发表时间: 2024-02
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Jiang, Na;Zhou, Zefeng;Niu, Jia
• 通讯作者: Niu, Jia

Degradable Vinyl Random Copolymers via Photocontrolled Radical Ring‐Opening Cascade Copolymerization**

通过光控自由基环的可降解乙烯基无规共聚物——开级联聚合**

• DOI: 10.1002/anie.202113302
• 发表时间: 2022-02
• 期刊: Angewandte Chemie International Edition
• 作者: Wang, Wenqi;Zhou, Zefeng;Sathe, Devavrat;Tang, Xuanting;Moran, Stephanie;Jin, Jing;Haeffner, Fredrik;Wang, Junpeng;Niu, Jia
• 通讯作者: Niu, Jia

Regulating cationic polymerization: From structural control to life cycle management

调控阳离子聚合：从结构控制到生命周期管理

• DOI: 10.1016/j.progpolymsci.2023.101736
• 发表时间: 2023-10
• 期刊: Progress in Polymer Science
• 影响因子: 27.1
• 作者: Wu, Lianqian;Rondon, Brayan;Dym, Shoshana;Wang, Wenqi;Chen, Kuiru;Niu, Jia
• 通讯作者: Niu, Jia

Cascade Reactions in Chain-Growth Polymerization

链增长聚合中的级联反应

• DOI: 10.1021/acs.macromol.0c00417
• 发表时间: 2020-06-26
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: Jingsong Yuan;Wenqi Wang;Zefeng Zhou;Jia Niu
• 通讯作者: Jia Niu

Macrocyclic Allylic Sulfone as a Universal Comonomer in Organocatalyzed Photocontrolled Radical Copolymerization with Vinyl Monomers

大环烯丙基砜作为有机催化光控自由基共聚与乙烯基单体的通用共聚单体

• DOI: 10.1021/acs.macromol.2c02025
• 发表时间: 2023-01-18
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: Wenqi Wang;B. Rondon;Zeyu Wang;Junpeng Wang;Jia Niu
• 通讯作者: Jia Niu