Collaborative Research: Development and Evaluation of a Miniature Coaxial Ion Trap Mass Analyzer for Portable Chemical Analysis

合作研究：用于便携式化学分析的微型同轴离子阱质量分析仪的开发和评估

• 批准号: 2003667
• 负责人: Daniel Austin
• 金额: $ 16.53万
• 依托单位: Brigham Young University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2003667&HistoricalAwards=false
• 关键词: Collaborative; Research; Development; Evaluation; Miniature

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Drs. Nicholas Taylor and Kristina Lemmer at Western Michigan University and Daniel Austin at Brigham Young University are working to develop a novel miniaturized instrument for field-portable chemical analysis based on a powerful method known as mass spectrometry. Specifically, the team seeks to develop a device capable of more detailed and yet faster analysis than is currently possible in field-portable analyzers. The ability to provide industry and the scientific community with a simple, lightweight, and portable tool capable of rapid in situ chemical measurements can have a societal impact on many areas including biochemistry, pharmacology, environmental monitoring, threat detection, industrial monitoring and quality control, as well as planetary exploration. The work is being conducted by undergraduate and graduate students in chemistry and aerospace engineering, including members of underrepresented groups. This cross-disciplinary collaboration resonates with NSF’s goal to enhance convergence research while inspiring and helping train the next generation of scientists and engineers.Field portable systems equipped with highly miniaturized ion trap mass analyzers will possess the ability to rapidly and reliably make quantitative chemical measurements of a wide range of molecular species. The novel coaxial ion trap being designed and build by the Taylor team utilizes a rectilinear ion guide (RIG) for efficient injection of internally or externally generated ions into a high capacity simplified toroidal ion trap (STorIT) for ion accumulation and storage. Ions of analytical interest stored in the toroidal trapping region are mass selectively injected into a cylindrical ion trap (CIT) nested within the toroidal trapping ring. The process of spatially isolating ions for MSn analysis can be repeated for a range of species without having to repopulate the toroidal trapping region, enhancing analytical efficiency. Since a single mass is injected into the CIT for MSn analysis, there is an inherent reduction in chemical noise which enhances the device’s detection limits and identification confidence. The system is being modeled and experimentally evaluated through a collaborative effort between Western Michigan University and Brigham Young University. Three target applications will allow testing of key performance features: rapid analysis of suspected illegal drug powders, sensitive detection of tracer compounds used in natural gas and petroleum wells, and characterization of semi-volatile compounds in atmospheric aerosols.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学测量和成像项目的支持下，西密歇根大学的 Nicholas Taylor 和 Kristina Lemmer 博士以及杨百翰大学的 Daniel Austin 正在致力于开发一种基于具体而言，该团队致力于开发一种能够比目前的现场便携式分析仪进行更详细、更快速分析的设备，从而为工业和科学界提供简单、轻便和可靠的分析方法。便携式工具能够进行快速原位化学测量可以对许多领域产生社会影响，包括生物化学、药理学、环境监测、威胁检测、工业监测和质量控制以及行星探索。这项工作是由化学专业的本科生和研究生进行的。这种跨学科合作与 NSF 的目标相呼应，即加强融合研究，同时激励和帮助培训下一代科学家和工程师。配备高度小型化离子阱质量的现场便携式系统。分析仪将能够快速、可靠地对各种分子种类进行定量化学测量。泰勒团队设计和建造的新型同轴离子阱利用直线离子导向器 (RIG) 来有效注入内部或外部产生的物质。将离子注入高容量简化环形离子阱 (STorIT) 中，以进行离子积累和存储 存储在环形捕获区域中的分析所需离子被选择性地注入圆柱形离子阱中。 (CIT) 嵌套在环形捕获环内，可以对一系列物质重复空间隔离离子的过程，而无需重新填充环形捕获区域，从而提高了分析效率。 MSn 分析显示，化学噪声固有地减少，从而提高了设备​​的检测限和识别置信度。西密歇根大学和杨百翰三大学正在合作对系统进行建模和实验评估。目标应用将允许测试关键性能特征：快速分析可疑的非法药物粉末，灵敏检测天然气和石油井中使用的示踪化合物，以及大气气溶胶中半挥发性化合物的表征。该奖项反映了 NSF 的法定使命，并具有通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Varying the aspect ratio of toroidal ion traps: Implications for design, performance, and miniaturization

• DOI: 10.1016/j.ijms.2021.116703
• 发表时间: 2021-09-11
• 期刊: INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
• 影响因子: 1.8
• 作者: Hettikankanange, Praneeth M.;Austin, Daniel E.
• 通讯作者: Austin, Daniel E.

Simplified coaxial ion trap: Simulation-based geometry optimization, unidirectional ejection, and trapping conditions

简化的同轴离子阱：基于仿真的几何优化、单向喷射和捕获条件

• DOI: 10.1016/j.ijms.2022.116801
• 发表时间: 2022
• 期刊: International Journal of Mass Spectrometry
• 影响因子: 1.8
• 作者: Gamage, Radhya W.;Hettikankanange, Praneeth M.;Lyman, Kyle D.;Austin, Daniel E.;Taylor, Nicholas R.
• 通讯作者: Taylor, Nicholas R.