A wearable monolithic wireless multi-sensor system based on reflected impedance

基于反射阻抗的可穿戴单片无线多传感器系统

• 批准号: 1933318
• 负责人: Ellis Meng
• 金额: $ 36.11万
• 依托单位: University of Southern California
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1933318&HistoricalAwards=false
• 关键词: wearable; monolithic; wireless; multi; sensor

Wireless sensing of many biomedical parameters of interest at once can provide crucial information about disease or overall health state. However, in current practice, biomedical sensing is most often limited to tracking only a single parameter which is inadequate to monitor the multiple factors and their interplay that influence health or disease state. Although many sensor types are currently available, their miniaturization and integration are greatly limited by the need for many additional discrete components necessary for functions such as data readout, powering, and wireless operation. Consequently, resulting multi-sensor system are complex assemblies with significant bulk that prevent their practical implementation in a wearable format. Compact, wearable multi-sensor systems that operate wirelessly have many potential applications in personalized and preventative medicine and monitoring health. In the proposed project, the reflected impedance wireless sensing technology will be leveraged to develop wearable systems that chronically monitor analytes in sweat and interstitial fluid. Potential applications include the artificial pancreas to achieve tight glucose regulation in diabetics comparable to that of healthy individuals, wound healing monitoring to prevent sepsis and infection, real-time quantification of hydration and exertion in high performance athletes, and heart failure monitoring in patients with cardiovascular diseases. This project will provide training opportunities via research experiences for female and underrepresented minority student researchers. To provider further opportunities for diverse audiences to engage with the research outcomes, educational products such as laboratory demonstrations and exercises will be developed that are suitable for both undergraduate and graduate students.The goal of this project is to leverage the recent discovery of wireless operation using the reflected impedance principle so that multiple unpowered microsensors can wirelessly communicate data capturing changes in electrochemical impedance. For this effort, we will utilize a core wearable platform consisting of a flexible microcoil, integrated thin film bridge capacitor, and sensing electrodes. An external reader wirelessly linked to the wearable platform completes the system. To advance ultra-compact form factor wireless multi-sensor systems, the major tasks include: (1) advancing the theory of wireless reflected impedance sensing, (2) determining factors that enable maximization of performance, (3) developing general design rules for reflected impedance systems that support multiple sensors, and (4) demonstrating under simulated conditions the wireless sensing of multiple analytes by reflected impedance. For the purpose of demonstration, tailored coatings will be applied to the sensing electrode as needed to achieve selectivity to well characterized markers: glucose, cortisol, and ions. The underlying principle of reflected impedance sensing is generalizable for application to other areas of biomedical sensing, including chronically implanted sensors. Adapting different functional coatings enable impedance-based detection of other analytes relevant to other disease conditions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

立即无线感测许多感兴趣的生物医学参数可以提供有关疾病或整体健康状况的重要信息。然而，在当前实践中，生物医学传感通常仅限于跟踪单个参数，这不足以监测影响健康或疾病状态的多个因素及其相互作用。尽管目前有许多传感器类型可用，但它们的小​​型化和集成度由于需要数据读出、供电和无线操作等功能所需的许多附加分立元件而受到极大限制。因此，所得到的多传感器系统是复杂的组件，体积很大，阻碍了它们以可穿戴形式的实际实施。无线操作的紧凑型可穿戴多传感器系统在个性化和预防医学以及健康监测方面具有许多潜在的应用。在拟议的项目中，反射阻抗无线传感技术将用于开发可长期监测汗液和间质液中分析物的可穿戴系统。潜在的应用包括人工胰腺，以实现糖尿病患者与健康人相当的严格血糖调节，伤口愈合监测以预防败血症和感染，实时量化高性能运动员的水合和运动量，以及心血管患者的心力衰竭监测疾病。该项目将通过研究经验为女性和代表性不足的少数族裔学生研究人员提供培训机会。为了为不同的受众提供更多参与研究成果的机会，将开发适合本科生和研究生的实验室演示和练习等教育产品。该项目的目标是利用最近发现的无线操作反射阻抗原理使得多个未供电的微传感器可以无线通信捕获电化学阻抗变化的数据。为此，我们将利用一个由柔性微线圈、集成薄膜桥电容器和传感电极组成的核心可穿戴平台。无线连接到可穿戴平台的外部读取器完善了该系统。为了推进超紧凑型无线多传感器系统，主要任务包括：(1) 推进无线反射阻抗传感理论，(2) 确定能够实现性能最大化的因素，(3) 制定反射阻抗传感的通用设计规则。支持多个传感器的阻抗系统，以及 (4) 在模拟条件下演示通过反射阻抗无线感测多个分析物。出于演示目的，将根据需要将定制涂层应用于传感电极，以实现对明确表征的标记物的选择性：葡萄糖、皮质醇和离子。反射阻抗传感的基本原理可以推广到生物医学传感的其他领域，包括长期植入的传感器。 采用不同的功能涂层可以基于阻抗检测与其他疾病状况相关的其他分析物。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。