REU Site: Molecular Biology and Genetics of Cell Signaling

REU 网站：细胞信号传导的分子生物学和遗传学

• 批准号: 1950247
• 负责人: Jun Liu
• 金额: $ 36.59万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1950247&HistoricalAwards=false
• 关键词: REU; Site; Molecular; Biology; Genetics

This REU Site award to Cornell University, located in Ithaca, NY, will support the training of 10 students for 10 weeks during the summers of 2020- 2022. It is anticipated that a total of 30 students, primarily from schools with limited research opportunities or are from an under-represented group, will be trained in the program. Students will learn how research is conducted, and many will present the results of their work at scientific conferences. Assessment of the program will be done through the online SALG URSSA tool. Students will be tracked after the program in order to determine their career paths.The goal of this program is to provide a formative research experience for talented undergraduate students, especially those from underrepresented and disadvantaged groups, that will motivate them to pursue a career in research, help them to be competitive for admission to research intensive graduate programs, and increase their success in these programs. The research focus is in the area of molecular signaling, a process that is fundamental to almost every cellular event. Training faculty are selected from various departments across the campus based on their research interests and their commitment to mentoring undergraduate research. In addition to conducting research in one of the participating labs, weekly REU group meetings with the program directors and various workshops provide students with a broad view of the signaling field in the general area of molecular sciences, opportunities to improve their communication skills, information about graduate school and careers in science, and awareness of responsible conduct of research. Students are also required to take pre- and post-program surveys for program assessment purposes. Students entering their sophomore, junior, or senior years, and majoring in the life sciences are encouraged to apply. Preference will be given to students with strong interest in gaining research experience in preparation for graduate study. Details on the application process, participating mentors and other information about the program are available by visiting https://mbg.cornell.edu/undergraduate/summer-research-experience/, or by contacting the PI (Dr. Kelly Liu at [e-mail]) or the co-PI (Dr. Tim Huffaker at [e-mail]). This award is supported by the Department of Defense ASSURE program thru a partnership with the NSF REU program.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

REU 授予位于纽约州伊萨卡的康奈尔大学的场地奖将支持 10 名学生在 2020 年至 2022 年夏季为期 10 周的培训。预计总共 30 名学生，主要来自研究机会有限的学校或来自代表性不足的群体，将接受该计划的培训。学生将了解如何进行研究，许多人将在科学会议上展示他们的工作成果。该计划的评估将通过在线 SALG URSSA 工具进行。项目结束后将对学生进行跟踪，以确定他们的职业道路。该项目的目标是为有才华的本科生，特别是那些来自弱势群体的学生提供形成性的研究经验，这将激励他们从事研究事业，帮助他们在进入研究密集型研究生项目时具有竞争力，并提高他们在这些项目中的成功率。研究重点是分子信号传导领域，这是几乎所有细胞事件的基础过程。培训教师是根据他们的研究兴趣和指导本科生研究的承诺从校园各个部门中挑选出来的。除了在参与实验室之一进行研究外，每周与项目主任举行的 REU 小组会议和各种研讨会为学生提供了分子科学一般领域信号领域的广阔视野、提高沟通技巧的机会、有关研究生院和科学职业，以及负责任的研究行为的意识。学生还需要参加项目前和项目后调查以进行项目评估。鼓励进入大二、大三或大四的生命科学专业学生申请。将优先考虑对获得研究经验以准备研究生学习有浓厚兴趣的学生。有关申请流程、参与导师以及有关该项目的其他信息的详细信息，请访问 https://mbg.cornell.edu/undergraduate/summer-research-experience/，或联系 PI（Kelly Liu 博士，JL53@ cornell.edu）或联合 PI（Tim Huffaker 博士，[e-mail]）。该奖项由国防部 ASSURE 计划通过与 NSF REU 计划的合作提供支持。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Exo1-protected DNA nicks direct crossover formation in meiosis

Exo1 保护的 DNA 切口在减数分裂中直接交叉形成

• DOI: 10.1101/2021.08.29.458102
• 发表时间: 2021
• 期刊: bioRxiv
• 作者: Gioia M, Payero L

A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain.

• DOI: 10.1021/acschembio.3c00092
• 发表时间: 2023-05-19
• 期刊: ACS CHEMICAL BIOLOGY
• 影响因子: 4
• 作者: Anmangandla, Ananya;Jana, Sadhan;Peng, Kewen;Wallace, Shamar D.;Bagde, Saket R.;Drown, Bryon S.;Xu, Jiashu;Hergenrother, Paul J.;Fromme, J. Christopher;Lin, Hening
• 通讯作者: Lin, Hening

SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans.

• DOI: 10.1371/journal.pbio.3002272
• 发表时间: 2023-08
• 期刊: PLoS biology
• 影响因子: 9.8