CAREER:Shedding New Light on the Miracle of Life

事业：为生命的奇迹带来新的曙光

• 批准号: 1922936
• 负责人: Audrey Bowden
• 金额: $ 9.45万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1922936&HistoricalAwards=false
• 关键词: CAREER; Shedding; New; Light; Miracle

#1351981P.I.: Audrey EllerbeeThe primary research objective of this CAREER Development Proposal (CDP) is to investigate the potential of morphological and biomechanical characteristics to predict viability in the early-stage embryo. This CDP incorporates a well integrated plan for research and education, and biomechanical characteristics to predict viability in the early-stage embryo. The broadly construed aims include: a) hardware development, b) software development, c) scientific experimentation, d) curricular enhancement, e) educational outreach, and f) science policy: This CDP will produce new hardware and software technology to investigate and fundamental questions about changes to the Aphysical properties of the embryo in the moments and hours following fertilization and early development, as well as use that technology to answer some such questions. Together with my collaborators, I will perform the first-in-human studies necessary to validate the relevance and significance of this methodology to address questions regarding fertility that are of broad interest to developmental biologists. In view of recent evidence of the predictive power of imaging-based markers for assessing the viability of embryos, the results of this CDP will likely transform the clinical practice of fertility treatments like in-vitro fertilization.

＃1351981P.I。：该职业发展建议的主要研究目标（CDP）是为了研究形态和生物力学特征的潜力，以预测早期胚胎的生存能力。该CDP纳入了一个综合的研究和教育计划，以及预测早期胚胎生存能力的生物力学特征。广泛解释的目的包括：a）硬件开发，b）软件开发，c）科学实验，d）课程增强，e）教育宣传和f）科学政策：该CDP将生产新的硬件和软件技术，以调查和基础关于在受精和早期发育后的时刻和几个小时内对胚胎的形成性特性变化的问题，以及使用该技术来回答一些此类问题。与我的合作者一起，我将进行必要的第一个人类研究，以验证这种方法的相关性和意义，以解决有关发育生物学家广泛感兴趣的生育问题的问题。鉴于最近证明基于成像标记的预测能力在评估胚胎的可行性方面的预测能力，该CDP的结果可能会改变生育治疗的临床实践，例如体外受精。