PFI-TT: Prototyping a Pesticide Detoxifier for High Value Crops

PFI-TT：为高价值作物制作农药解毒剂原型

基本信息

批准号：
1918981
负责人：
Jin Montclare
金额：
$ 25万
依托单位：
New York University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2022-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1918981&HistoricalAwards=false
关键词：
PFI TT Prototyping Pesticide Detoxifier

项目摘要

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project will result in a safe and effective way to ensure full detoxification and removal of commonly used pesticides in the protection of several different crops such as wine grapes and tea leaves. Many pesticides cannot be easily removed with water, and, therefore, pose a public health risk as these pesticides persist on the surface of these products. This project will develop a protein-based technology that can break down a particular class of pesticide called organophosphates into two benign products that can be more easily removed with water. Through this, consumers could more easily enjoy fruits and vegetables protected by this particular class of pesticides. The proposed project will result in the collaboration of protein engineers, chemists, and computer scientists. Ultimately, the team plans to develop a single protein designed by computer scientists, produced by protein engineers, and stabilized by chemists. Computer scientists, experts in the design of proteins with improved function, will provide the blueprint for the protein engineers to develop in the lab. The protein engineers will produce the proteins and assess their efficacy with several commonly used pesticides. The chemists will then encapsulate the crystals in a sugar to ensure the products' efficacy following storage of several months. A diverse group of scientists will bring new ideas to solve the problem of pesticide persistence on the surfaces of fruits and vegetables, as well as develop a commercially viable solution for this pervasive problem.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这种伙伴关系对创新 - 技术翻译（PFI -TT）项目的更广泛的影响/商业潜力将导致一种安全有效的方法，以确保完全排毒并去除常用农药，以保护几种不同的农作物，例如葡萄酒葡萄和茶叶。由于这些农药在这些产品的表面持续存在，因此许多农药不能轻易地用水造成公共卫生风险。该项目将开发一种基于蛋白质的技术，该技术可以将一种称为有机磷酸盐的特定农药分解为两种良性产品，可以更轻松地用水去除。通过此，消费者可以更轻松地享受受这种特殊类型农药保护的水果和蔬菜。拟议的项目将导致蛋白质工程师，化学家和计算机科学家的合作。最终，该团队计划开发由蛋白质工程师生产并由化学家稳定的计算机科学家设计的单一蛋白质。计算机科学家，具有改善功能的蛋白质设计专家，将为蛋白质工程师提供在实验室中开发的蓝图。蛋白质工程师将产生蛋白质并用几种常用的农药评估其功效。然后，化学家将将晶体封装在糖中，以确保储存几个月后产物的功效。一群多样化的科学家将带来新的想法，以解决水果和蔬菜表面上的农药持久性问题，并为这个普遍的问题开发了可行的解决方案。这项奖项反映了NSF的法定任务，并通过评估该基金会的知识分子优点和广泛的影响来评估NSF的法定任务，并被视为值得的支持。