Cryptic Hydrogels

隐秘水凝胶

• 批准号: 1905559
• 负责人: Shelly Peyton
• 金额: $ 58.82万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1905559&HistoricalAwards=false
• 关键词: Cryptic; Hydrogels

Non-Technical AbstractHydrogels are a class of material that can become swollen with water, and they represent an increasingly important category of materials in research and commerce. They are employed as biomaterials, contact lenses, absorbent materials, wound healing materials, water retention aids, coatings, adhesives, and many other applications. However, unlike many other type of plastic materials typically used in industry, these hydrogels are typically very weak, and there is currently no robust mechanism to strengthen the materials on-demand. Building this attribute into these hydrogel systems would significantly enhance their real-world applications. In sum, this process costs one to ten billion dollars, and seven to twenty years per drug. This project will create a way to strengthen gels by applying force to them, with specific applications toward better, more robust adhesives. They will also use this funding to create new educational opportunities for students. Specifically, high school women will be brought into the lab during the summer months, where they can work with these and other sophisticated materials and diverse researchers. Technical AbstractHydrogel and organogel networks are swollen, insoluble polymer networks made from soluble monomer precursors, and they are an increasingly important class of materials in research and commercial applications. Their uses are far-reaching in both academia and industry, as biomaterials and wound healing materials; controlled delivery materials and networks; contact lenses; coatings; and adhesives. One critical limitation for gels has been that, in comparison to industrial thermoplastic polymers, they cannot be strengthened in response to mechanical deformation. Building on-demand stiffening into gel systems could greatly broaden their full potential and utility in applications as stable and mechanically robust adhesives, coatings, fabricated articles, and potentially biomaterials. In this project, a team of three laboratories will 1) Create and characterize poly(ethylene glycol) (PEG) gels with strain-induced stiffening properties, both irreversible and electrostatic (reversible) crosslinks, 2) Incorporate shielding groups into the networks to tune their force sensitivity, and 3) apply this technology to mechanically-activated adhesives. These studies will establish fundamental relationships between molecular and environmental parameters and strain-triggered elastic modulus changes with a new class of materials. This work will provide the scientific foundation for hydrogel property control via strain-triggered stiffening or softening mechanisms. This contribution is significant because the eventual applications of this fundamental knowledge could apply to materials design for new hydrophilic materials as well as regenerative medicine and disease. Outreach objectives in this proposal will continue current efforts developed by the PIs in previous NSF-funded broader impacts in expanding engineering research opportunities tailored for high school girls.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术性抽象性凝固凝胶是一类材料，可能会因水而肿胀，它们代表了研究和商业中越来越重要的材料类别。它们被用作生物材料，隐形眼镜，吸收性材料，伤口愈合材料，保留辅助工具，涂料，粘合剂和许多其他应用。但是，与行业通常使用的许多其他类型的塑料材料不同，这些水凝胶通常非常弱，目前没有强大的机制来加强按需增强材料。将此属性构建到这些水凝胶系统中将显着增强其实际应用。总而言之，此过程的费用为1至100亿美元，每名药物耗资7到二十年。 该项目将通过向它们施加力，并为更好，更强大的粘合剂施加力来增强凝胶。他们还将利用这笔资金为学生创造新的教育机会。 具体而言，高中妇女将在夏季将其带入实验室，在那里她们可以与这些和其他复杂的材料以及多样化的研究人员一起工作。技术抽象thydrogel和Oranogel网络肿胀，由可溶性单体前体制成的不溶性聚合物网络，它们是研究和商业应用中越来越重要的材料类别。作为生物材料和伤口愈合材料，它们在学术界和工业中的使用范围很深远。受控的送货材料和网络；隐形眼镜；涂料；和粘合剂。凝胶的一个关键局限性是，与工业热塑性聚合物相比，无法响应机械变形而得到加强。将按需加固到凝胶系统中，可以极大地扩大其在应用中的全部潜力和实用性，因为它是稳定且机械强大的粘合剂，涂料，制造的物品以及潜在的生物材料。在这个项目中，由三个实验室组成的团队将1）创建和表征具有应变诱导的僵硬性能的聚（乙烯乙二醇）（PEG）凝胶，包括不可逆和静电（可逆）交叉链接，2）将屏蔽组融合到网络中，以将其力敏感性和3）应用于机械激活的技术。这些研究将建立分子和环境参数之间的基本关系，以及通过一系列新材料变化的应变触发弹性模量变化。这项工作将通过应变触发的僵硬或软化机制为水凝胶性质控制提供科学基础。这项贡献很重要，因为这种基本知识的最终应用可能适用于新的亲水材料以及再生医学和疾病的材料设计。该提案中的宣传目标将继续由PIS在以前的NSF资助以扩大针对高中女生量身定制的工程研究机会方面开展的最新努力。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的审查标准通过评估来通过评估来支持的。

项目成果

Strain-Stiffening Hydrogels with Dynamic, Secondary Cross-Linking

具有动态二次交联的应变硬化水凝胶

• DOI: 10.1021/acs.langmuir.2c03117
• 发表时间: 2023
• 期刊: Langmuir
• 影响因子: 3.9
• 作者: Sonu, K. P.;Zhou, Le;Biswas, Santidan;Klier, John;Balazs, Anna C.;Emrick, Todd;Peyton, Shelly R.
• 通讯作者: Peyton, Shelly R.