Cryptic Hydrogels

隐秘水凝胶

• 批准号: 1905559
• 负责人: Shelly Peyton
• 金额: $ 58.82万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1905559&HistoricalAwards=false
• 关键词: Cryptic; Hydrogels

Non-Technical AbstractHydrogels are a class of material that can become swollen with water, and they represent an increasingly important category of materials in research and commerce. They are employed as biomaterials, contact lenses, absorbent materials, wound healing materials, water retention aids, coatings, adhesives, and many other applications. However, unlike many other type of plastic materials typically used in industry, these hydrogels are typically very weak, and there is currently no robust mechanism to strengthen the materials on-demand. Building this attribute into these hydrogel systems would significantly enhance their real-world applications. In sum, this process costs one to ten billion dollars, and seven to twenty years per drug. This project will create a way to strengthen gels by applying force to them, with specific applications toward better, more robust adhesives. They will also use this funding to create new educational opportunities for students. Specifically, high school women will be brought into the lab during the summer months, where they can work with these and other sophisticated materials and diverse researchers. Technical AbstractHydrogel and organogel networks are swollen, insoluble polymer networks made from soluble monomer precursors, and they are an increasingly important class of materials in research and commercial applications. Their uses are far-reaching in both academia and industry, as biomaterials and wound healing materials; controlled delivery materials and networks; contact lenses; coatings; and adhesives. One critical limitation for gels has been that, in comparison to industrial thermoplastic polymers, they cannot be strengthened in response to mechanical deformation. Building on-demand stiffening into gel systems could greatly broaden their full potential and utility in applications as stable and mechanically robust adhesives, coatings, fabricated articles, and potentially biomaterials. In this project, a team of three laboratories will 1) Create and characterize poly(ethylene glycol) (PEG) gels with strain-induced stiffening properties, both irreversible and electrostatic (reversible) crosslinks, 2) Incorporate shielding groups into the networks to tune their force sensitivity, and 3) apply this technology to mechanically-activated adhesives. These studies will establish fundamental relationships between molecular and environmental parameters and strain-triggered elastic modulus changes with a new class of materials. This work will provide the scientific foundation for hydrogel property control via strain-triggered stiffening or softening mechanisms. This contribution is significant because the eventual applications of this fundamental knowledge could apply to materials design for new hydrophilic materials as well as regenerative medicine and disease. Outreach objectives in this proposal will continue current efforts developed by the PIs in previous NSF-funded broader impacts in expanding engineering research opportunities tailored for high school girls.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要水凝胶是一类可以遇水膨胀的材料，它们代表了研究和商业中日益重要的材料类别。它们被用作生物材料、隐形眼镜、吸收材料、伤口愈合材料、保水助剂、涂料、粘合剂和许多其他应用。然而，与工业中通常使用的许多其他类型的塑料材料不同，这些水凝胶通常非常脆弱，并且目前没有强有力的机制来按需强化材料。将这种属性构建到这些水凝胶系统中将显着增强它们的实际应用。总之，这个过程花费一到一百亿美元，每种药物需要七到二十年的时间。 该项目将创建一种通过对凝胶施加力来增强凝胶的方法，并针对更好、更坚固的粘合剂进行特定应用。他们还将利用这笔资金为学生创造新的教育机会。 具体来说，高中女性将在夏季被带入实验室，在那里她们可以使用这些和其他复杂的材料以及不同的研究人员。技术摘要水凝胶和有机凝胶网络是由可溶性单体前体制成的溶胀、不溶性聚合物网络，它们是研究和商业应用中日益重要的一类材料。它们作为生物材料和伤口愈合材料，在学术界和工业界都有着深远的用途；受控交付材料和网络；隐形眼镜；涂料；和粘合剂。凝胶的一个关键限制是，与工业热塑性聚合物相比，它们不能响应机械变形而得到强化。在凝胶系统中构建按需硬化可以极大地拓宽其在作为稳定且机械坚固的粘合剂、涂料、制品和潜在生物材料的应用中的全部潜力和效用。在该项目中，由三个实验室组成的团队将 1) 创建并表征具有应变诱导硬化特性的聚乙二醇 (PEG) 凝胶，包括不可逆交联和静电（可逆）交联，2) 将屏蔽基团纳入网络中以进行调整它们的力敏感性，以及 3) 将此技术应用于机械活化粘合剂。这些研究将建立分子和环境参数以及新型材料的应变触发弹性模量变化之间的基本关系。这项工作将为通过应变触发的硬化或软化机制控制水凝胶性能提供科学基础。这一贡献意义重大，因为这一基础知识的最终应用可以应用于新型亲水材料以及再生医学和疾病的材料设计。该提案中的外展目标将继续 PI 在之前 NSF 资助的更广泛影响中所制定的努力，以扩大为高中女生量身定制的工程研究机会。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力评估进行评估，被认为值得支持。优点和更广泛的影响审查标准。

项目成果

Strain-Stiffening Hydrogels with Dynamic, Secondary Cross-Linking

具有动态二次交联的应变硬化水凝胶

• DOI: 10.1021/acs.langmuir.2c03117
• 发表时间: 2023
• 期刊: Langmuir
• 影响因子: 3.9
• 作者: Sonu, K. P.;Zhou, Le;Biswas, Santidan;Klier, John;Balazs, Anna C.;Emrick, Todd;Peyton, Shelly R.
• 通讯作者: Peyton, Shelly R.