Tailorable, responsive, and morphologically-tunable plasmonic chiroptical nanoparticle superstructures

可定制、响应性和形态可调的等离子体手性光学纳米颗粒超结构

• 批准号: 1904960
• 负责人: Nathaniel Rosi
• 金额: $ 51.96万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1904960&HistoricalAwards=false
• 关键词: Tailorable; responsive; morphologically; tunable; plasmonic; Tailorable; responsive; morphologically; tunable; plasmonic

Non-Technical SummaryThe study and control of chiral nanoscale materials are rapidly growing areas of research. A chiral material is something that cannot be superimposed on its mirror image, like a left and a right hand. Chiral nanomaterials have the potential to serve as sensors for disease markers, as catalysts for important industrial chemical processes, and as components in optical devices as mundane as a camera and as exotic as an invisibility cloak. This research, which is jointly supported by the Solid State and Materials Chemistry program and the Biomaterials program at NSF, focuses on the development and advancement of chiral nanoscale materials assembled from gold nanoparticles. The researchers at the University of Pittsburgh advance fundamental insights into the construction of these materials and optimization of the unique optical properties that underscore their practical promise. This fundamental research involves participation from a diverse group of graduate and undergraduate researchers, who communicate their discoveries in scientific publications and presentations, as well as in science demonstrations for the general public. Additionally, to increase diversity in the chemical sciences the principle investigator engages in targeted recruiting activities.Technical SummaryRecent years have witnessed the emergence of a wide variety of chiral nanoparticle superstructures that exhibit unique plasmonic chiroptical properties. To propel this field forward and to ultimately realize the technological promise of these materials, research efforts must focus on the following challenges: i) deliberate optimization of plasmonic chiroptical properties; ii) design and preparation of dynamic and responsive plasmonic chiroptical materials; and iii) development of sustainable and scalable syntheses and efficient means of material manipulation to allow for their more widespread study and use. The central goal of this research, which is jointly supported by the Solid State and Materials Chemistry program and the Biomaterials program at NSF, is to address these challenges by leveraging molecular methods for constructing nanoparticle superstructures that rely on peptide conjugate molecules to direct nanoparticle synthesis and assembly. The PI and his group: i) elucidate how the molecular composition and structure of peptide conjugate molecules affects the assembly, structure, and properties of helical gold nanoparticle superstructures; ii) develop new approaches for fabricating photo-responsive helical nanoparticle superstructures exhibiting 'on/off' plasmonic chiroptical behavior which is coupled to reversible molecular transformations; iii) establish strategies for controlling the length and surface chemistry of helical nanoparticle superstructures; and iv) develop new, sustainable approaches for preparing helical nanoparticle superstructures. The findings illuminate how molecular-level alterations to peptide precursors translates into dramatic nanoscale alterations to the assembly, metrics, and properties of helical nanoparticle superstructures. The transformational impact of the research lies in the ability to precisely control the structure of nano- to microscale materials using molecular chemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要的手性纳米级材料的研究和控制是迅速增长的研究领域。手性材料是无法在其镜像上叠加的东西，例如左手和右手。手性纳米材料有可能作为疾病标记物的传感器，作为重要工业化学过程的催化剂，以及在像摄像机一样平凡的光学设备中的组成部分，并且像隐形斗篷一样具有异国情调。这项研究由NSF的固态和材料化学计划和生物材料计划共同支持，重点是从金纳米颗粒组装的手性纳米级材料的开发和进步。匹兹堡大学的研究人员对这些材料的构建以及优化独特的光学特性的优化，强调其实践承诺。这项基本研究涉及来自一群研究生和本科研究人员的参与，他们在科学出版物和演讲中传达了他们的发现，以及在科学演示中为公众传达的。此外，为了增加化学科学的多样性，主要研究者参与有针对性的招募活动。技术摘要年份见证了出现了各种表现出独特的等离子脊髓性特性的多种手性纳米粒子上层结构。为了推动这一领域的前进并最终实现这些材料的技术承诺，研究工作必须集中在以下挑战上：i）故意优化等离子体的授权性能； ii）设计和制备动态和响应的等离子手流材料； iii）开发可持续和可扩展的合成以及有效的物质操纵手段，以允许其更广泛的研究和使用。这项研究的核心目标是由NSF的固态和材料化学计划和生物材料计划共同支持的，它是通过利用分子方法来解决这些挑战，用于构建依赖肽结合分子的纳米颗粒超结构，以直接纳米颗粒的合成和组件。 PI及其组：i）阐明肽结合分子的分子组成和结构如何影响螺旋金纳米粒子上层建筑的组装，结构和特性； ii）开发新的方法，用于制造具有“ ON/OFF”等离子体手术行为的光子响应性螺旋纳米颗粒上层建筑，并与可逆的分子转化耦合； iii）建立控制螺旋纳米颗粒上层建筑的长度和表面化学的策略； iv）开发了准备螺旋纳米颗粒上层建筑的新的可持续方法。这些发现阐明了分子级对肽前体的改变如何转化为螺旋纳米粒子上层结构的组装，指标和性质的戏剧性纳米级改变。研究的变革影响在于能够使用分子化学精确控制纳米材料的结构。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的智力优点和更广泛影响的评估来评估值得支持的。