RUI-Collaborative Research-Electrokinetic Transport and Electric Field Control of Ion Motion through the Interior of Single-Walled Carbon Nanotubes

RUI-合作研究-单壁碳纳米管内部离子运动的电动输运和电场控制

• 批准号: 1904453
• 负责人: Michael Strano
• 金额: $ 5.89万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1904453&HistoricalAwards=false
• 关键词: RUI; Collaborative; Research; Electrokinetic; Transport; RUI; Collaborative; Research; Electrokinetic; Transport

Dr. Mark Ellison of the Department of Chemistry, Ursinus College and Dr. Michael S. Strano of the Department of Chemical Engineering, Massachusetts Institute of Technology (MIT) are supported by the Macromolecular, Supramolecular, and Nanochemistry (MSN) Program of the Division of Chemistry to study the motion of ions and molecules through the interior of carbon nanotubes. Flow of material at these dimensions is quite different from our everyday experience, so this research is expected to improve our understanding of how these ions and molecules are transported through tubes that are not much bigger in diameter than the objects themselves. The work is initially focused on the transport of amino acids and neurotransmitters, including acetylcholine and dopamine through the nanotubes. At a later stage, the nanotubes are outfitted with tiny gold electrodes to control the rate of flow through the tubes using an electric signal. If successful, the project is likely to impact the development of biosensing, medical testing, and electronic nanodevices. It is also likely to improve our understanding of the motion of biologically important molecules in biological channels and synthetic nanopores such as in the human brain. During the course of conducting this research, a diverse group of undergraduate students as well as female high school students are afforded a research experience at Ursinus College. In addition, the students benefit from visits to MIT to prepare nanotube devices and conduct experiments with the help of MIT graduate students. The project investigates the fundamental processes of the transport of small ions and molecules through single wall nanotubes (SWNTs). Chemical vapor deposition (CVD) is used to deposit SWNTs on silicon wafers and the devices are equipped with electrodes to conduct the needed ion current measurements. This, combined with SEM and Raman spectroscopy measurements, provides the necessary data to characterize the devices and to provide information on the mechanisms involved in the transport of ionic and molecular species through the nanotubes. The Ursinus undergraduate students travel to MIT to use equipment and instruments such as a chemical vapor deposition oven, scanning electron microscope, and a Raman microscope to construct the SWNT devices. The devices are brought back to Ursinus to conduct the voltage clamp measurements of ion transport. The work is initially focused on the transport of amino acids and neurotransmitters, including acetylcholine and dopamine, through the nanotubes. At a later stage, the nanotubes are outfitted with gold electrodes to gate and control the rate of flow through the tubes by an electric signal. The experiments are designed to provide the data needed to improve our understanding of ion and molecule transport through SWCNT nanopores and to explore the use of SWCNTs as conduits for the delivery of amino acids and neurotransmitters to specific targets.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

马萨诸塞州技术学院化学系化学系的马克·埃里森（Mark Ellison）博士和马萨诸塞州理工学院化学工程系的迈克尔·斯特拉诺（Michael S.在这些维度上的材料流与我们的日常体验完全不同，因此，这项研究有望提高我们对这些离子和分子如何通过直径不大的管运输的理解。这项工作最初集中在氨基酸和神经递质的运输上，包括乙酰胆碱和多巴胺通过纳米管。在稍后的阶段，纳米管配备了微小的金电极，以使用电信号控制通过管道的流动速率。如果成功，该项目可能会影响生物传感，医学测试和电子纳米台词的发展。 它还可能提高我们对生物学上重要分子在生物学通道和合成纳米孔（例如人脑）中的运动的理解。 在进行这项研究的过程中，在Ursinus College获得了一群多样化的本科生和女学生。此外，学生从访问MIT的访问中受益，以准备纳米管设备，并在MIT研究生的帮助下进行实验。该项目研究了小离子和分子通过单壁纳米管（SWNT）的基本过程。化学蒸气沉积（CVD）用于将SWNT沉积在硅晶片上，并且设备配备了电极来进行所需的离子电流测量。与SEM和拉曼光谱测量相结合，提供了必要的数据来表征设备并提供有关通过纳米管运输和分子物种运输的机制的信息。 Ursinus本科生前往MIT，使用设备和仪器，例如化学蒸气沉积烤箱，扫描电子显微镜和拉曼显微镜来构建SWNT设备。 这些设备被带回Ursinus，以进行离子传输的电压夹具测量。这项工作最初集中在氨基酸和神经递质（包括乙酰胆碱和多巴胺）通过纳米管的运输上。在以后的阶段，纳米管配备了金电极，以通过电信号来栅极和控制通过管道的流动速率。该实验旨在提供所需的数据，以提高我们对通过SWCNT纳米孔的离子和分子传输的理解，并探索将SWCNT用作氨基酸和神经递质传递的管道的使用，以反映NSF的法定任务，并通过评估了基金会的Merit anditial and Interviatial and Interviatial and Iffiena和Broadial and Intive和BroadIrial and Intive and InteriT和BroadIrial and Intive and Interiat and Intive and Intive and Intern和BroadIrial and Intipal和BroadIrial and Intipal and Intif。