CAREER: Determine the Roles of Material Heterogeneity and Thickness Variability on the Stability of Thin Membranes

职业：确定材料异质性和厚度变异性对薄膜稳定性的作用

• 批准号: 1847062
• 负责人: Shuodao Wang
• 金额: $ 50万
• 依托单位: Oklahoma State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1847062&HistoricalAwards=false
• 关键词: CAREER; Determine; Roles; Material; Heterogeneity

This Faculty Early Career Development Program (CAREER) award will support integrated research and educational efforts to generate new knowledge of how material and thickness non-uniformity (also referred to as heterogeneity) in thin, bio-compatible materials and bio-tissues affect their mechanical behaviors under various deformation conditions. Examples of such materials include ultra-thin wearable bio-sensors, the eardrum membrane, and the heart valves. The award supports fundamental research that will enable a currently unavailable, non-destructive material characterization protocol for obtaining the material property maps, which will allow the deformation and stability of these materials to be better understood. The innovative approach in this project is expected to promote scientific advancement in new mechanics knowledge that is important for a wide range of healthcare and biomedical applications, thereby impacting the national health and economy. The project will provide opportunities to train graduate and undergraduate students in the important interdisciplinary areas of mechanics, materials science, and biomedical devices. The educational outreach activities are designed to engage young children and under-represented minorities in STEM education, with the goal of enlarging the STEM talent pool for the nation.Many important natural and synthesized heterogeneous thin membranes wrinkle under very small loads. Stability of thin structures has long been a canonical problem in the mechanics community. Yet to date, huge discrepancies in buckling loads between theories and experiments are still usually accounted for by empirical corrections. There is a clear lag in understanding for predicting the buckling loads of thin heterogeneous membranes. The objective of this CAREER project is to test the hypothesis that a higher degree of heterogeneity in thin membranes reduces the critical buckling loads. The research approach is to experimentally measure and compare the buckling loads of a set of thin membranes of various degrees of heterogeneity ranging from highly heterogeneous to homogeneous. Fluorescence stereo microscopy and inverse finite element analysis will be combined to extract the material property distributions and thickness variability, and then a theory-guided numerical model will be developed to identify a quantitative degree of heterogeneity and elucidate how it is related to reduced buckling loads.This project is jointly funded by the Civil, Mechanical, and Manufacturing Innovation program (CMMI), and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项教师早期职业发展计划（职业）奖将支持综合研究和教育努力，以在薄薄的生物兼容材料和生物组织中如何在各种变形条件下影响其机械行为，从而为材料和厚度非均匀性（也称为异质性）产生新的知识。 此类材料的例子包括超薄可穿戴生物传感器，耳膜和心脏瓣膜。 该奖项支持基础研究，该研究将使目前不可用的，无损的材料表征协议用于获得材料特性图，这将使这些材料的变形和稳定性得到更好的理解。预计该项目的创新方法将促进新力学知识的科学进步，这对于广泛的医疗保健和生物医学应用很重要，从而影响了国家卫生和经济。 该项目将提供机会在力学，材料科学和生物医学设备的重要跨学科领域培训毕业生和本科生。 教育外展活动旨在使幼儿和代表性不足的少数民族参与STEM教育，目的是扩大国家的STEM人才库。在很小的负载下，许多重要的自然和合成的异质薄膜皱纹。薄结构的稳定性长期以来一直是机械界的规范问题。然而，迄今为止，理论和实验之间的屈曲负载巨大差异通常仍由经验校正来解释。理解可预测薄膜的屈曲负荷的明确滞后。该职业项目的目的是检验以下假设：薄膜中更高程度的异质性减少了关键的屈曲载荷。研究方法是通过实验测量和比较一组薄膜的屈曲负荷，这些薄膜各种程度的异质性范围从高度异质到同质性。荧光立体显微镜和逆有限元分析将结合起来，以提取材料特性分布和厚度可变性，然后将开发理论指导的数值模型，以确定定量的异质性程度，并阐明其与屈曲载荷相关的，这些项目由民事，机械竞争计划和制造计划（CMMI）共同资助（CMMI），并建立了该项目。 （EPSCOR）。该奖项反映了NSF的法定使命，并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准来评估值得支持的。

项目成果

An investigation of how specimen dimensions affect biaxial mechanical characterizations with CellScale BioTester and constitutive modeling of porcine tricuspid valve leaflets

使用 CellScale BioTester 和猪三尖瓣小叶的本构模型研究样本尺寸如何影响双轴机械特性

• DOI: 10.1016/j.jbiomech.2023.111829
• 发表时间: 2023
• 期刊: Journal of Biomechanics
• 影响因子: 2.4
• 作者: Laurence, Devin W.;Wang, Shuodao;Xiao, Rui;Qian, Jin;Mir, Arshid;Burkhart, Harold M.;Holzapfel, Gerhard A.;Lee, Chung-Hao
• 通讯作者: Lee, Chung-Hao

Machine learning based inverse modeling of full-field strain distribution for mechanical characterization of a linear elastic and heterogeneous membrane

基于机器学习的全场应变分布逆建模，用于线性弹性和异质膜的机械表征

• DOI: 10.1016/j.mechmat.2021.104134
• 发表时间: 2022
• 期刊: Mechanics of Materials
• 影响因子: 3.9
• 作者: Zhang, Yuan;Guo, Lin;Brousse, Clement J.A.;Lee, Chung-Hao;Azoug, Aurelie;Lu, Hongbing;Wang, Shuodao
• 通讯作者: Wang, Shuodao