SBIR Phase I: Ultrasensitive chip-scale ion-sensors for mass spectrometry

SBIR 第一阶段：用于质谱分析的超灵敏芯片级离子传感器

• 批准号: 1843742
• 负责人: Daniel Esposito
• 金额: $ 22.37万
• 依托单位: GUARDION, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1843742&HistoricalAwards=false
• 关键词: SBIR; Phase; Ultrasensitive; chip; scale

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will benefit manufacturers of residual gas analyzers, mass spectrometers, ion-mobility spectrometers, time-of-flight spectrometers and related instruments. Implementation of these sensors will increase the revenue, revenue streams and market share of commercial manufacturers of mass spectrometers by significantly lowering production cost, and by enabling penetration into new markets that require increased sensitivity, lowered size, weight, power consumption, and instrument complexity. The product, if successful, will lead to analytical tools that can substantially benefit the needs of education/research, space, bio/health, agricultural, defense and security markets.This Small Business Innovation Research (SBIR) Phase I project will develop nanotechnology-based chip-scale ion sensors with ultra-high intrinsic charge-to-current amplification factors. This patent-pending technology allows semiconductor-processable miniaturization and scalability, sub-microwatt intrinsic power draw, and robust ambient-pressure-agnostic operation. With reduced size, weight, and power requirements, increased sensitivity and dynamic range, these sensors can potentially replace expensive, bulky, and/or high-power-consuming charged particle detectors such as microchannel plates, Daly detectors, electron-multiplier tubes and Faraday cups. The ability to operate under any ambient pressure and distinguish charge polarity can significantly enhance field-portability, turnkey operations, and enhance analytical reach of ion-sensing-based applications. Specifically, the proposed research will seek to overcome the challenges related to generation of high signal responses (by enhancing the electronic transport parameters), high ion-sensor interaction (by optimizing sensor design), and lower readout noise (by optimizing materials and design).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I期项目的更广泛的影响/商业潜力将使剩余汽油分析仪，质谱仪，离子移动性光谱仪，飞行飞行时间光谱仪和相关工具的制造商受益。这些传感器的实施将通过显着降低生产成本，并使需要提高敏感性，尺寸降低，体重，功耗和仪器复杂性来增加质谱商商业制造商的收入，收入流和市场份额。该产品如果成功，将导致分析工具，可以实质上有利于教育/研究，空间，生物/健康，农业，国防和安全市场的需求。这项小型企业创新研究（SBIR）I阶段项目将开发纳米技术 - 具有超高固有电荷到电流扩增因子的基于芯片尺度的离子传感器。这项正在申请专利的技术允许半导体可加工的微型化和可扩展性，亚微波固有功率抽取以及强大的环境压力 - 不合骨的操作。随着尺寸，重量和功率需求的减小，灵敏度和动态范围的提高，这些传感器可能会替代昂贵，笨重和/或高功率的带电粒子探测器，例如微通道板，Daly探测器，电子探测器，电子 - 型型管和Faraday，杯子。在任何环境压力下运行并区分电荷极性的能力可以显着提高现场通货性，交钥匙操作并增强基于离子感应应用的分析范围。具体而言，拟议的研究将寻求克服与产生高信号响应（通过增强电子传输参数），高离子传感器相互作用（通过优化传感器设计）和降低读出噪声（通过优化材料和设计）较低的挑战（通过优化材料和设计）该奖项反映了NSF的法定任务，并通过使用基金会的智力优点和更广泛的影响审查标准来评估值得支持。