RCN-UBE Incubator: Preparing a Network to Develop Molecular Case Studies at the Interface of Biology and Chemistry

RCN-UBE 孵化器：准备网络以开发生物学和化学交叉点的分子案例研究

• 批准号: 1827011
• 负责人: Shuchismita Dutta
• 金额: $ 7.5万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1827011&HistoricalAwards=false
• 关键词: RCN; UBE; Incubator; Preparing; Network

Understanding structure-function relationships is foundational to learning biology. In lower-division courses, students study the shapes and functions of selected proteins and nucleic acids. However, deep understanding of structure-function relationships requires visualizing the structure, mapping information from various biological data resources (e.g., polymer sequence, interactions, mutations, variations) onto the structure, and applying biology and/or chemistry knowledge to synthesize explanations of function. Unfortunately, these activities are not common in undergraduate biology curricula. Collaboration between biology, chemistry, and biochemistry educators to adapt molecular visualization approaches currently being used in chemistry can benefit biology education. To that end, the aim of this project is to establish a network of interested faculty that will create case studies, an effective active-learning technique, to teach the relationship between molecular structure and function. The cases will enable students to visualize and analyze challenging real-world problems in atomic detail and apply their biology and/or chemistry knowledge to develop solutions. These molecular visualizations will provide a platform for integrating knowledge from different sub-disciplines of biology, such as biochemistry, genetics, and cell biology to form the foundation for practicing interdisciplinary, team science across STEM disciplines.This RCN-UBE project will establish a new network, Molecular CaseNet, to develop case studies at the interface of biology and chemistry. Objectives of the incubator phase of this project are to 1) bring together an interdisciplinary team of seven scientists and researchers to develop an exemplar for case-study design and determine format requirements for future case studies; 2) create two model case studies focused on specific biological processes/events and discussed at a molecular level; and 3) present the cases in community workshops and professional society meetings to recruit new members to the network and gather feedback on usability, clarity, and relevance of the case studies. Piloting the newly developed case studies with selected student groups will shed light on the relevance of these case studies in learning biology, chemistry, and biochemistry. By using the planned case studies, students with varied levels of expertise and disciplinary training will have the opportunity to understand molecular structure-function relationships and practice the scientific process to address real-world problems. In turn, this practice will help prepare the next generation of workers in STEM fields to creatively apply interdisciplinary approaches to problem-solving.This project is being jointly funded by the Directorate for Biological Sciences, Division of Biological Infrastructure, and the Directorate for Education and Human Resources, Division of Undergraduate Education as part of their efforts to address the challenges posed in Vision and Change in Undergraduate Biology Education: A Call to Action (http://visionandchange/finalreport/).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

理解结构与功能的关系是学习生物学的基础。在低年级课程中，学生研究选定蛋白质和核酸的形状和功能。然而，对结构-功能关系的深入理解需要将结构可视化，将来自各种生物数据资源（例如聚合物序列、相互作用、突变、变异）的信息映射到结构上，并应用生物学和/或化学知识来综合功能的解释。不幸的是，这些活动在本科生物课程中并不常见。生物学、化学和生物化学教育工作者之间的合作，以适应目前化学中使用的分子可视化方法，可以使生物学教育受益。为此，该项目的目的是建立一个由感兴趣的教师组成的网络，该网络将创建案例研究，这是一种有效的主动学习技术，以教授分子结构与功能之间的关系。这些案例将使学生能够在原子细节上可视化和分析具有挑战性的现实世界问题，并应用他们的生物学和/或化学知识来开发解决方案。这些分子可视化将为整合生物学不同子学科（例如生物化学、遗传学和细胞生物学）的知识提供一个平台，为跨 STEM 学科实践跨学科、团队科学奠定基础。该 RCN-UBE 项目将建立一个新的Molecular CaseNet 网络，用于在生物学和化学领域开展案例研究。该项目孵化器阶段的目标是 1) 组建一个由七名科学家和研究人员组成的跨学科团队，开发案例研究设计的范例，并确定未来案例研究的格式要求； 2）创建两个专注于特定生物过程/事件的模型案例研究并在分子水平上进行讨论； 3) 在社区研讨会和专业协会会议上展示案例，以招募新成员加入网络，并收集有关案例研究的可用性、清晰度和相关性的反馈。与选定的学生团体一起试点新开发的案例研究将阐明这些案例研究在学习生物学、化学和生物化学方面的相关性。通过使用计划的案例研究，具有不同专业水平和学科训练的学生将有机会了解分子结构-功能关系并实践解决现实问题的科学过程。反过来，这种做法将有助于培养 STEM 领域的下一代工作者，创造性地运用跨学科方法来解决问题。该项目由生物科学局、生物基础设施司以及教育和教育局共同资助本科教育人力资源部作为其努力解决本科生物教育愿景和变革：行动呼吁 (http://visionandchange/finalreport/) 中提出的挑战的一部分。该奖项反映了 NSF 的法定使命，并已通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

The Molecular Case Study Cycle

分子案例研究周期

• 发表时间: 2020-12
• 期刊: CCCE Newsletter
• 作者: Dutta; S.
• 通讯作者: S.

Students authoring molecular case studies as a partial course‐based undergraduate research experience (CURE) for lab instruction

学生创作分子案例研究作为部分课程——基于本科生研究经验 (CURE) 进行实验室指导

• DOI: 10.1002/bmb.21578
• 发表时间: 2021-11
• 期刊: Biochemistry and Molecular Biology Education
• 影响因子: 1.4
• 作者: Riley KJ;Vardar-Ulu D;Pollock E;Dutta S
• 通讯作者: Dutta S