RAPID: Fabrication of Bioinspired Plasmonic Nanoarrays for Biosensing and Trace Chemical Detection

RAPID：用于生物传感和痕量化学检测的仿生等离子体纳米阵列的制造

• 批准号: 1841853
• 负责人: Marco De Jesus
• 金额: $ 15.02万
• 依托单位: University of Puerto Rico Mayaguez
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1841853&HistoricalAwards=false
• 关键词: RAPID; Fabrication; Bioinspired; Plasmonic; Nanoarrays

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, and the Biosensors and the Biological & Environmental Interactions of Nanoscale Materials Programs in the Division of Chemical, Bioengineering, Environmental, and Transport Systems, Dr. Marco De Jesus and his group at the University of Puerto Rico - Mayaguez are mimicking nature to create a new generation of advanced, high performance, materials which interact with light in unusual and potentially useful ways. In collaboration with the Center for Nanophase Materials Sciences (CNMS) at Oak Ridge National Laboratory, the team is assessing the impact of detailed design on the performance of particle arrays for faster and more reproducible analysis of samples such as antimicrobials, emerging pollutants, and bioactive agents of biomedical and environmental significance. Results of these studies may impact areas of national interest including the construction of solar cells, advanced optical sensors, and molecular probes. The project is providing interdisciplinary training and research opportunities to a diverse group of undergraduate and graduate students in nanotechnology, chemical sensing, and bioanalytical chemistry.This project seeks to improve our current understanding of how nanomaterials interact with bioactive agents at the liquid/solid interface. Specifically, in collaboration with ORNL-CNMS, Dr. De Jesus and his team assess the efficiency of plasmonic responses on metallic surfaces as a function of nanoparticle morphology, interparticle spacing, and spatial resolution. They are particularly interested in the impact of these properties on the loading capacity and quantitative working range of these materials for chemical sensing applications. Using competitive binding experiments and multivariate Raman analysis, they seek to identify the structural dependence of surface interactions of mixed chemical agents to elucidate surface selectivity and trends for practical quantitation of mixtures. The successful completion of this project may provide new advances toward the rational design of nanomaterials with tailored properties for trace chemical analysis. The work provides research and training opportunities for a diverse group of UPRM undergraduate and graduate students in nanotechnology applied to chemical systems, with direct exposure of the graduate students to state-of-the-art facilities at CNMS.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学测量和成像计划中的支持下，在化学，生物工程，环境和运输系统的纳米级材料计划的生物传感器以及生物学与环境相互作用的支持下，马可·德·耶稣（Marco de Jesus）及其小组在波黎港大学（University of Puerto -rico -Mayaguez）中，玛雅人（Mayaguez）的梅米克（Mayaguez）是模仿新一代材料的相互作用，并与高级表演相互作用，并在较高的材料中相互作用。 与Oak Ridge国家实验室的纳米相材料科学中心（CNM）合作，该团队正在评估详细设计对粒子阵列性能的影响，以更快，更可再现的样品分析，例如抗菌剂，新兴污染物，以及生物医学和环境的生物污染物，以及生物医学和环境意义的生物活性药物。 这些研究的结果可能会影响国家关注的领域，包括建造太阳能电池，晚期光学传感器和分子探针。该项目正在为纳米技术，化学传感和生物分析化学的各种本科和研究生提供跨学科的培训和研究机会。该项目旨在提高我们对纳米材料如何与液体/固体界面上的生物活性剂相互作用的当前理解。具体而言，De Jesus博士及其团队与ORNL-CNMS合作评估了等离激元反应的效率，这是金属表面的效率，这是纳米颗粒形态，粒子间距和空间分辨率的函数。他们对这些特性对这些材料的负载能力和定量工作范围的影响特别感兴趣。使用竞争性结合实验和多元拉曼分析，他们试图确定混合化学剂的表面相互作用的结构依赖性，以阐明表面选择性和趋势的实际定量混合物。该项目的成功完成可能为具有量身定制的特性用于痕量化学分析的纳米材料的合理设计提供了新的进步。 这项工作为多元化的UPRM本科生和纳米技术研究生提供了研究和培训机会，并将研究生直接接触到CNM的最先进的设施中。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识优点和广泛的crietia crietia crietia criperia进行评估，并被认为是值得通过评估的。