An integrative analysis of the primate skeleton

灵长类骨骼的综合分析

基本信息

批准号：
1830745
负责人：
Noreen von Cramon-Taubadel
金额：
$ 31.5万
依托单位：
SUNY at Buffalo
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1830745&HistoricalAwards=false
关键词：
integrative analysis primate skeleton

项目摘要

Our understanding of human origins is primarily based on the analysis of fossilized skeletons, rather than genetic information. However, unlike the underlying genetic code, the skeleton changes substantially throughout life, and different parts of the skeleton are integrated with one another through varying genetic, developmental, and functional processes. This project will use state-of-the-art 3D scanning and statistical methods to assess the nature and extent of skeletal integration across primates in order to test how morphological diversity across primates came about. The results will provide information about the degree to which the human skeleton is unique or similar to other living primates. As such, this project advances our understanding of the human body and provides a roadmap for future researchers interested in reconstructing genetic relationships from fossils. The research advances the careers of several female scientists, including one researcher from a group underrepresented in STEM research, provides technical training for graduate and undergraduate students, and will result in an extensive database of virtual primate models that will be shared with the scientific community. In addition, active outreach programs through Buffalo's school system will promote K-12 science through engagement with virtual technology.Researchers often compartmentalize the primate skeleton, with cranial and postcranial elements often studied in isolation. This has led to the empirical dissociation of adaptive integrated systems, and a lack of understanding of how components of the skeleton co-vary. This project will collate a large 3D database of skeletal elements for 13 anthropoid taxa and construct covariance matrices reflecting functional, developmental, and anatomical modularity. Quantitative genetic analyses will be used to test the nature and extent of integration patterns across primates and assess which modules have been shaped by neutral versus non-neutral forces. The results will create a direct link between the pattern and magnitude of integration and the past forces that shaped primate skeletal diversity more broadly, thus providing future researchers with a better understanding of which traits best reflect neutral divergence, and which have been subject to adaptive forces.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

我们对人类起源的理解主要是基于对化石骨骼而不是遗传信息的分析。但是，与潜在的遗传密码不同，骨骼在整个生命中都有很大变化，并且骨骼的不同部分通过不同的遗传，发育和功能过程彼此集成。该项目将使用最先进的3D扫描和统计方法来评估灵长类动物之间骨骼整合的性质和程度，以测试灵长类动物之间的形态多样性。结果将提供有关人类骨骼独特或与其他生物灵长类动物相似的程度的信息。因此，该项目提高了我们对人体的理解，并为对重建化石遗传关系感兴趣的未来研究人员提供了路线图。这项研究促进了几位女科学家的职业，其中包括一名来自STEM研究中代表性不足的研究人员，为研究生和本科生提供了技术培训，并将导致广泛的虚拟灵长类动物模型数据库与科学界分享。此外，通过布法罗的学校系统的积极宣传计划将通过与虚拟技术的参与来促进K-12科学。研究人员经常将灵长类动物的骨骼划分，而颅骨和颅后元素经常孤立地研究。这导致了自适应综合系统的经验分离，并且缺乏对骨架的共同变化方式的了解。该项目将为13个人类类似群和构建协方差矩阵整理一个大的3D数据库，以反映功能，发育和解剖模块。定量遗传分析将用于测试灵长类动物之间整合模式的性质和程度，并评估哪些模块是由中性和非中性力塑造的。结果将在整合的模式和大小之间建立直接联系，而过去的力量更广泛地塑造了灵长类动物的骨骼多样性，从而为未来的研究人员提供了更好地理解哪些特征最能反映中性差异的，这些特征已受到适应力量的影响，并受到了NSF的法定任务，并通过评估范围来反映了众所周知的范围。