PFI-TT: Bioresorbable multi-functional optical sensor for brain implant

PFI-TT：用于脑植入的生物可吸收多功能光学传感器

• 批准号: 1827693
• 负责人: Weidong Zhou
• 金额: $ 20万
• 依托单位: University of Texas at Arlington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1827693&HistoricalAwards=false
• 关键词: PFI; TT; Bioresorbable; multi; functional

The broader impact/commercial potential of this PFI project: During clinical, surgical and rehabilitation steps, various sensor/monitor techniques are used to monitor brain function and other physiological parameters. However, current sensors are hard, rigid, bulky and dependent on fragile cables that can act as a nidus for infection in contaminated traumatic wounds. The associated surgical retrieval procedures, meanwhile, are costly and they subject patients to distress associated with re-operation and expose them to additional complications. On the other hand, bioresorbable electronics can be used for post-surgical monitoring of organ, tissue, implant, and wound health without the need for surgical extraction, thus reducing the risk of infection and complications during and after the surgical processes. The proposed innovation will open up numerous and diverse applications in medical, security, and consumer markets. Bioresorbable electronics can potentially move much closer to commercial reality in the next few years, with the promise of revolutionary advances in health care and environmental protection, resulting in broad social and economic impacts. Technology leadership in these areas will increase the economic competitiveness of the United States, advancing the health and welfare of the American public, enhancing partnerships between academia and industry, and developing an American STEM workforce that is globally competitive.The proposed project is to develop a bioresorbable bio-implantable multi-functional optical probe for simultaneous monitoring of brain intracranial pressure (ICP), temperature, and oxygenation. The initial target market of the technology is brain monitors for the efficient treatment of patients during recovery following a severe Traumatic brain injury (TBI). With this NSF PFI-PR project, various technical challenges at the interface between optics, electronic/optical materials, processes of bio-resorption, brain interfaces, advanced manufacturing, and commercial scaling will be addressed. The modular design approach proposed here involves an implantable bioresorbable probe head coupled to a pluggable/flexible external optical head, to shorten the product design cycle and reduce the cost. The self-compensating design for the fully bioresorbable optical/temperature sensor system will ensure accurate readings of physiological parameters, which are typically sensitive to environmental variations. A built-in self-calibration evanescent waveguide sensor pair enables autonomous long-term sensor accuracy. This bioresorbable systems can be designed to have the specific functional lifetimes, after which all of the constituent materials under complete bio-absorption, thereby eliminating the need for surgery, and associated risks to the patient, to remove the devices. Additionally, electrically passive operation and complete immunity to electromagnetic interference represent two important advantages of the proposed optical pressure sensors.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 PFI 项目更广泛的影响/商业潜力：在临床、手术和康复步骤中，使用各种传感器/监测技术来监测大脑功能和其他生理参数。然而，当前的传感器坚硬、僵硬、体积庞大，并且依赖于脆弱的电缆，这些电缆可能成为受污染的创伤性伤口感染的病灶。与此同时，相关的手术取出手术费用昂贵，并且使患者承受与再次手术相关的痛苦，并使他们面临额外的并发症。另一方面，生物可吸收电子器件可用于器官、组织、植入物和伤口健康的术后监测，无需手术提取，从而降低手术过程中和手术后感染和并发症的风险。拟议的创新将在医疗、安全和消费市场中开辟大量多样化的应用。生物可吸收电子产品有可能在未来几年内更加接近商业现实，有望在医疗保健和环境保护方面取得革命性进展，从而产生广泛的社会和经济影响。这些领域的技术领先地位将提高美国的经济竞争力，促进美国公众的健康和福利，加强学术界和工业界之间的伙伴关系，并培养具有全球竞争力的美国 STEM 劳动力。拟议的项目是开发生物可吸收生物植入式多功能光学探头，用于同时监测脑颅内压 (ICP)、温度和氧合。该技术的最初目标市场是脑部监测仪，用于在严重创伤性脑损伤（TBI）后的恢复过程中对患者进行有效治疗。通过这个 NSF PFI-PR 项目，光学、电子/光学材料、生物吸收过程、脑接口、先进制造和商业规模之间的接口的各种技术挑战将得到解决。这里提出的模块化设计方法涉及将植入式生物可吸收探头耦合到可插拔/柔性外部光学头，以缩短产品设计周期并降低成本。完全生物可吸收光学/温度传感器系统的自补偿设计将确保生理参数的准确读数，这些参数通常对环境变化敏感。内置自校准倏逝波导传感器对可实现自主的长期传感器精度。这种生物可吸收系统可以设计为具有特定的功能寿命，之后所有组成材料都处于完全生物吸收状态，从而消除了手术的需要以及患者移除装置的相关风险。此外，电无源操作和完全不受电磁干扰是所提出的光学压力传感器的两个重要优势。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

• DOI: 10.1038/s41551-019-0435-y
• 发表时间: 2019-08-01
• 期刊: NATURE BIOMEDICAL ENGINEERING
• 影响因子: 28.1
• 作者: Bai, Wubin;Shin, Jiho;Rogers, John A.
• 通讯作者: Rogers, John A.

Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature

• DOI: 10.1126/sciadv.aaw1899
• 发表时间: 2019-07-01
• 期刊: SCIENCE ADVANCES
• 影响因子: 13.6
• 作者: Shin, Jiho;Liu, Zhonghe;Rogers, John A.
• 通讯作者: Rogers, John A.