MRI: Acquisition of a versatile, user-friendly, automated fluorescence microscope to promote research performed by faculty and undergraduates at a Hispanic-serving institution

MRI：购买多功能、用户友好的自动荧光显微镜，以促进西班牙裔服务机构的教师和本科生进行的研究

基本信息

批准号：
1826871
负责人：
Andrea Holgado
金额：
$ 20.73万
依托单位：
Saint Edward's University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-10-01 至 2021-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1826871&HistoricalAwards=false
关键词：
MRI Acquisition versatile user friendly

项目摘要

An award is made to St. Edward's University (SEU) to do state-of-the-art fluorescence microscopy as part of faculty-mentored research and course-based undergraduate research experiences (CUREs). SEU is a minority-serving institution with a diverse student body, many of whom are first-generation college students. Faculty-mentored research at SEU is usually their first exposure to novel scientific research. The acquisition of this microscope improves the research infrastructure by promoting the quality of faculty-sponsored independent research, increasing and enhancing the number of cell-molecular experiments performed as part of CUREs, and broadening the types of outreach programs involving Austin Community College students and K-12 teachers and students. Finally, this microscope will provide needed synergy with other current NSF-funded projects at SEU.Fluorescence microscopy allows the detection and analysis of molecular and cellular structures, molecular dynamics, and gene expression through a panoply of widely available fluorophore-conjugated molecules and genetically-encoded fluorescent proteins. This award facilitates the purchase of a microscope that is conducive to live imaging under controlled environments, high-sensitivity detection of faint fluorophores, optical sectioning of thick specimens, and 3D image acquisitions. The instrumentation enables the research of a highly diverse set of scientific programs at SEU: (1) Characterization of the interplay between cellular metabolic regulation and neurodevelopment in soil-dwelling nematodes, (2) Determination of the molecular mechanism underlying interactions between host cells and parasitic pathogens like those causing toxoplasmosis, (3) Understanding the molecular basis of variation for patterning of the egg shell in fruit flies, (4) Investigation of the bacterial targets of antimicrobial plant extracts and examination of the protective action of probiotics, and (5) Characterization of plant-fungal interactions in response to phosphate stress.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

授予圣爱德华大学（SEU），以进行最先进的荧光显微镜，这是教职员工研究和基于课程的本科研究经验（Cures）的一部分。 SEU是一个拥有多元化学生团体的少数派服务机构，其中许多是第一代大学生。 SEU的教职研究通常是他们首次接触新的科学研究。通过促进教师赞助的独立研究的质量，增加和增强了作为治疗方法的一部分进行的细胞分子实验数量，并扩大涉及奥斯汀社区大学生和K的外展计划的类型，从而改善了研究基础设施，从而改善了研究基础设施。 -12老师和学生。最后，该显微镜将与SEU的其他当前NSF资助的项目提供所需的协同作用。荧光显微镜可以通过众多可全面可用的荧光团结合的分子以及遗传性的 - 遗传 - 偶联的分子以及遗传 - 偶联的分子以及遗传 - 偶联的分子以及分子和细胞结构，分子动力学以及基因表达进行检测和分析。编码的荧光蛋白。该奖项有助于购买显微镜，该显微镜有利于在受控环境下进行现场成像，微弱的荧光团，厚标本的光学切片和3D图像采集。该仪器能够研究SEU高度多样化的科学程序集：（1）在土壤居住线虫中的细胞代谢调节与神经发育之间的相互作用表征（2）确定宿主相互作用的分子机制病原体像引起弓形虫病的病原体一样，（3）了解果蝇中蛋壳壳的变异的分子基础，（4）研究抗菌植物提取物的细菌靶标，并检查益生菌的保护作用，以及（5）该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响标准来评估值得支持的。