Phase II IUCRC at University of Kentucky: Center for Arthropod Management Technologies (CAMTech)

肯塔基大学 IUCCRC 第二阶段：节肢动物管理技术中心 (CAMTech)

基本信息

批准号：
1821936
负责人：
Subba Palli
金额：
$ 60万
依托单位：
University of Kentucky Research Foundation
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1821936&HistoricalAwards=false
关键词：
Phase II IUCRC University Kentucky

项目摘要

The development of new pest management approaches is critical for the production of sufficient food for the increasing human population, and for prevention of arthropod-transmitted disease to plants and humans. The more widespread pest distribution associated with changing climatic conditions exacerbates the need for new pest management tools. The economic losses associated with the activities of arthropods and nematodes are a significant burden to society through both agricultural losses and human health costs. The Center for Arthropod Management Technologies (CAMTech) addresses issues that limit effective management of the major insect and nematode pests that impact agriculture and human health. The center addresses the need for specific knowledge and research tools to expedite delivery of pest management solutions by industry partners to the marketplace, and to investigate both new approaches, and expansion of existing approaches for pest suppression. The major limitations in the field are common to the agricultural biotechnology and urban pest management industries and restrict widespread adoption of strategies shown to be effective in some systems. The center contributes key advances through state of the art, industrially relevant research and by training of graduate students and postdoctoral researchers including underrepresented groups, toward continued advancement of the field. CAMTech serves as a platform for innovative, interdisciplinary research activities at the interface of academia, government, and industry. Expertise in entomology and other departments at the University of Kentucky include insect physiology, genomics, population genetics, vector biology, and symbiosis. The research needs of industries in the agricultural biotechnology and human health domains align well with the expertise of university participants providing for the expedited development of pest management solutions to the benefit of agricultural sustainability and public wellbeing. Advanced methods including next-generation sequencing and -omics, confocal microscopy, RNA interference and genome editing are employed to conduct non-competitive research of crucial importance to the industrial sector. The research products are transferred to member companies through quarterly reports and presentations at bi-annual IAB meetings and to the public in the form of publications and presentations at conferences. Fundamental knowledge gained from center research on mechanisms of RNA interference, insecticide resistance, toxicological effects of insecticides, physiological processes of pests and disease vectors facilitate R&D efforts of industry and expedite the development of new products for pest and disease vector control.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

新的有害生物管理方法的发展对于为增加人口而产生足够的食物以及预防植物和人类的节肢动物传播疾病至关重要。与改变气候条件相关的害虫分布越广泛，这加剧了对新的害虫管理工具的需求。通过农业损失和人类健康成本，与节肢动物和线虫的活动相关的经济损失给社会带来了重大负担。节肢动物管理技术中心（CAMTECH）解决了限制影响农业和人类健康的主要昆虫和线虫的有效管理的问题。该中心解决了对特定知识和研究工具的需求，以加快行业合作伙伴向市场上提供有害生物管理解决方案，并调查两种新方法，并扩展现有方法以抑制害虫。该领域的主要局限性是农业生物技术和城市有害生物管理行业的共同限制，并限制了广泛采用在某些系统中有效的策略。该中心通过艺术，工业相关的研究以及对包括代表性不足的群体在内的研究生和博士后研究人员的培训来贡献重要的进步，以继续进步。 Camtech是学术界，政府和工业界面的创新，跨学科研究活动的平台。肯塔基大学昆虫学和其他系的专业知识包括昆虫生理学，基因组学，人群遗传学，载体生物学和共生。工业在农业生物技术和人类健康领域中的研究需求与大学参与者的专业知识非常吻合，从而为农业可持续性和公共福祉提供了加快的害虫管理解决方案的发展。采用了先进的方法，包括下一代测序和-OMICS，共聚焦显微镜，RNA干扰和基因组编辑，以对工业部门进行至关重要的重要性研究。研究产品通过每两年IAB会议上的季度报告和演讲转移给会员公司，并以会议的出版物和演示形式转移给公众。从中心研究RNA干扰，杀虫剂耐药性，杀虫剂的毒理学作用，害虫和疾病媒介的生理过程的基本知识中，这有助于行业的研发工作，并加快了害虫和疾病媒介控制的新产品。这反映了NSF的奖项。法定任务，并被认为是值得通过基金会的智力优点和更广泛影响的审查标准来评估的值得支持的。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Double-stranded RNA binding protein, Staufen, is required for the initiation of RNAi in coleopteran insects.

DOI：
10.1073/pnas.1809381115
发表时间：
2018-08-14
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Yoon JS;Mogilicherla K;Gurusamy D;Chen X;Chereddy SCRR;Palli SR
通讯作者：
Palli SR

Midgut-specific expression of CYP321A8 P450 gene increases deltamethrin tolerance in the fall armyworm Spodoptera frugiperda