Collaborative Research: Rates of lineage, phenotypic, and genomic diversification in replicated radiations of murine rodents

合作研究：小鼠啮齿动物复制辐射中的谱系、表型和基因组多样化率

• 批准号: 1754096
• 负责人: Jeffrey Good
• 金额: $ 33.5万
• 依托单位: University of Montana
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1754096&HistoricalAwards=false
• 关键词: Collaborative; Research; Rates; lineage; phenotypic

Much of the diversity of life has arisen through the process of adaptive radiation. Adaptive radiation occurs when a group rapidly diversifies into many species to fill a variety of ecological roles. While adaptive radiation is a common theme in the evolution of life, many of its features are poorly understood. This project seeks to better understand how adaptive radiation proceeds. The project will examine the rate of diversification in genes, morphology and species diversity over the evolutionary history of a group of rodents containing more than 600 species. The study will determine how changes in genes, morphology and species are correlated as the species diversified. Importantly, the group under study contains the common lab mouse and rat, two species that serve as scientific models in medical and basic research. This study will place these model organisms in an evolutionary context that will allow scientists to better understand how their genes and other characteristics have evolved. Such understanding provides new insight into genes and characteristics of medical significance. Scientific meetings organized by the researchers will bring together scientists who study mice and rats from different perspectives, including molecular biology and medicine, to share insight and generate new research questions. In addition to the broader impacts on basic science and medicine, public outreach and education events at participating natural history museums will use the results of this research to teach principles of evolutionary biology to K-12 students and improve public understanding of science.This project integrates comparative genomics with quantitative morphology in a rigorous phylogenetic framework to illuminate the dynamics of diversification in lineages, phenotypes, and genes across the most species-rich adaptive radiation in mammals. The exceptional species and ecomorphological diversity in rats and mice (subfamily Murinae, 634 living species) arose over the last 14 million years through replicate adaptive radiations, primarily in the distinct biogeographic units of Indo-Australia. This research will expand on the genomic resources from the leading mammalian model organisms to encompass the diversity of murine rodents by sequencing whole exomes from a large, phylogenetically dispersed set of species. In addition, the project will generate high-resolution, 3D morphometric models of cranial and post-cranial skeletons from the same species. The project will combine these distinct data layers to: estimate a species-level phylogeny of the Murinae; identify and date biogeographic and ecological transitions; estimate diversification rate shifts across the phylogeny; estimate rates of phenotypic and molecular evolution relative to transitions (biogeographic and ecological) and shifts in lineage diversification rate; test for correlations between the tempos of phenotypic and molecular evolution; and, quantify morphological and molecular convergence.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

通过适应性辐射的过程，生命的许多多样性都产生了。当一个群体迅速分散到许多物种以填补各种生态作用时，就会发生自适应辐射。虽然自适应辐射是生活进化中的一个共同主题，但其许多特征的理解很少。该项目旨在更好地了解自适应辐射如何进行。该项目将研究一组含有600多种啮齿动物的啮齿动物的进化史，基因，形态和物种多样性的多样化速率。该研究将确定基因，形态和物种的变化如何随着物种的多样化而相关。重要的是，研究的小组包含普通实验室小鼠和大鼠，这两个物种是医学和基础研究中的科学模型。这项研究将把这些模型生物置于进化的环境中，这将使科学家能够更好地了解其基因和其他特征如何发展。这种理解为基因和医学意义的特征提供了新的见解。研究人员组织的科学会议将召集从包括分子生物学和医学在内的不同角度研究小鼠和大鼠的科学家，分享洞察力并产生新的研究问题。除了对基础科学和医学的更广泛影响外，参与自然历史博物馆的公共宣传和教育活动还将利用这项研究的结果向K-12学生讲授进化生物学的原则，并提高公众对科学的理解。该项目将比较基因组学与严格的跨性化形态学的定量基因组相结合，以跨越多种多样的范围，跨越了多样化的范围。在哺乳动物中。在过去的1400万年中，大鼠和小鼠（亚家族穆利纳（Murinae），634种生物物种）中的特殊物种和生态学多样性通过复制的适应性辐射而产生，主要是在印度 - 澳大利亚的独特生物地理单位中。这项研究将从主要的哺乳动物模型生物体上扩展基因组资源，以涵盖鼠类啮齿动物的多样性，通过对大型，系统发育分散的物种集的整个外部进行测序。此外，该项目将产生来自同一物种的颅骨和颅后骨骼的高分辨率，3D形态学模型。该项目将将这些不同的数据层结合在一起：估计Murinae的物种级系统发育；识别和日期生物地理和生态过渡；估计多元化率在整个系统发育中变化；相对于过渡（生物地理和生态）以及谱系多样化率的转变，表型和分子进化的估计速率；测试表型和分子进化的节奏之间的相关性；并且，量化形态和分子融合。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的评论标准来评估值得支持的。

项目成果

The Evolution of Widespread Recombination Suppression on the Dwarf Hamster (Phodopus) X Chromosome.

• DOI: 10.1093/gbe/evac080
• 发表时间: 2022-05-31
• 期刊: GENOME BIOLOGY AND EVOLUTION
• 影响因子: 3.3
• 作者: Moore, Emily C.;Thomas, Gregg W. C.;Mortimer, Sebastian;Kopania, Emily E. K.;Hunnicutt, Kelsie E.;Clare-Salzler, Zachary J.;Larson, Erica L.;Good, Jeffrey M.
• 通讯作者: Good, Jeffrey M.

Molecular Evolution of Ecological Specialisation: Genomic Insights from the Diversification of Murine Rodents.

• DOI: 10.1093/gbe/evab103
• 发表时间: 2021-07-06
• 期刊: Genome biology and evolution
• 影响因子: 3.3
• 作者: Roycroft E;Achmadi A;Callahan CM;Esselstyn JA;Good JM;Moussalli A;Rowe KC
• 通讯作者: Rowe KC