I-Corps: Biodegradable Airway Stent for Tracheal Stenosis Management

I-Corps：用于气管狭窄管理的可生物降解气道支架

• 批准号: 1748674
• 负责人: Prashant Kumta
• 金额: $ 5万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1748674&HistoricalAwards=false
• 关键词: Corps; Biodegradable; Airway; Stent; Tracheal

The broader impact/commercial potential of this ICorps project is to prevent complications developing from the use of non-degradable permanent implants and ultimately reduce redo/replacement procedures in the healthcare field. The introduction of a novel family of biodegradable medical implants meets this intention. There is a sizeable market for biodegradable devices to treat various health conditions and address issues from existing therapeutics. The global biodegradable stent market is expected to grow significantly over the next ten years. Mortality from heart diseases and cancer is projected to increase through the year 2020. However, with appropriate minimally-invasive intervention, the number of deaths can potentially be reduced significantly. The high cost of follow-up procedures due to insertion of permanent stents urges healthcare industry to seek better alternatives. The ultimate goal is to boost the position of the United States as a leader in the global absorbable device market.This I-Corps project focuses on a biomaterial, a novel biodegradable magnesium based alloy that can be used to design and develop the biodegradable medical devices. Magnesium is already present in the human body and simply degrades safely from the stents over time. The invention provides a material composition for medical device like stents. The invented material exhibits high ductility and corrosion resistance acceptable for all medical devices requiring plasticity and ductility exceeding that of conventional magnesium alloys. Many disease complications in adults constrict or block a passage within the body, causing symptoms and wellness deterioration. Although surgical correction is preferred when technically feasible and permitted by the clinical status of patient, stenting is often a reliable alternative. Recent research has indicated that innovative technology platform points to safe and cost-effective biodegradable metallic stents, and will solve the problems caused by existing stents made of permanent materials like silicone, nitinol and polymers.

该ICORPS项目的更广泛的影响/商业潜力是防止使用不可降解的永久性植入物而发展并发症，并最终减少医疗保健领域中的重做/替代程序。新型可生物降解的医疗植入物的引入符合这种意图。可生物降解设备有一个相当大的市场，可以治疗各种健康状况并解决现有治疗剂的问题。预计全球可生物降解支架市场将在未来十年中显着增长。 心脏病和癌症的死亡率预计将在2020年增加。但是，通过适当的微创干预措施，死亡人数可能会大大减少。 由于插入永久性支架插入的高昂随访程序成本敦促医疗保健行业寻求更好的替代方案。最终目标是提高美国作为全球可吸收器件市场领导者的地位。该I-Corps项目着重于生物材料，这是一种新型可生物降解的基于可生物降解的镁合金，可用于设计和开发可生物降解的医疗设备。镁已经存在于人体中，随着时间的流逝，镁只是从支架上安全降解。本发明为像支架这样的医疗设备提供了材料组成。发明的材料表现出高延展性和耐腐蚀性，可用于所有需要超过常规镁合金的医疗设备。成年人的许多疾病并发症会收缩或阻止体内的通过，导致症状和健康恶化。尽管在技术上可行并通过患者的临床状况允许手术校正是优选的，但支架通常是可靠的选择。最近的研究表明，创新的技术平台指出了安全且具有成本效益的可生物降解的金属支架，并将解决由硅胶，硝基和聚合物等永久材料制成的现有支架引起的问题。