Chiral Ceramic Nanoparticles of Tungsten Oxides

氧化钨手性陶瓷纳米粒子

• 批准号: 1748529
• 负责人: Nicholas Kotov
• 金额: $ 52万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1748529&HistoricalAwards=false
• 关键词: Chiral; Ceramic; Nanoparticles; Tungsten; Oxides

NON-TECHNICAL SUMMARYChirality is a geometrical property describing objects that are not the same as their mirror images. Such objects are common in Nature and chirality determines the outcome of most biological processes. This project will study how to make nanoparticles of ceramics chiral in order to produce new drugs, reduce pollution, create new display technologies, improve biomedical implants, and realize new ultra-strong materials. These technological advances become possible because chirality of nanoscale ceramics can be combined with their special mechanical, optical, electronic, chemical, and biological properties. Synthetic methods, characteristic properties, and computational tools will be established. The surface of small particles of tungsten oxide will be coated with amino acids that will transfer their chirality to the inorganic material. The best conditions for the synthesis of long chain molecules, known as peptides, with specific chirality to be used as antibacterial drugs for biomedical and national defense needs, will be found. The outcome of this project will be a versatile toolbox for applied studies and education that will be available to other scientists, engineers, teachers, and the public. The low cost, biocompatibility and commonality of ceramic materials will enable utilization of chiral ceramics in many technological areas. The University of Michigan will collaborate with schools in poor communities in Detroit area to demonstrate importance of chirality to high and middle school students. The project will also help kids of high school age with speech impediments to find interesting research topics in chemistry, physics, materials, or mathematics.TECHNICAL SUMMARYChirality is a geometrical property with unifying importance for physics, chemistry, biology, astronomy, and mathematics. Nanoscale ceramics can be chiral, which will enhance mechanical, optical, electronic, chemical, and biological properties of these materials. These advances in ceramics will make possible a new generation of materials for polarization modulation devices, chiral catalysts, biomedical implants, biosensors, and drug carriers. Thus, a framework of synthetic methods, characteristic properties, and computational tools will be established in this project. As a model system, chiral ceramic nanoparticles of tungsten trioxide with L- and D- amino acid surface ligands adsorbed to their surface will be synthesized. These nanocolloids will be subsequently utilized in the catalysis of amino acid condensation into antibacterial peptides. Integrated training of students skillful in both computational and synthetic tools is essential to its impact of this project. The educational and outreach efforts will be focused on underrepresented minorities and middle- and high-school students from high-poverty Ypsilanti area. Kids of high school age with speech impediments will be engaged in the scientific research.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术总结是一种几何特性，描述与镜像图像不同的对象。 这种物体在本质上很常见，手性决定了大多数生物过程的结果。 该项目将研究如何制作陶瓷手性的纳米颗粒，以生产新药，减少污染，创造新的展示技术，改善生物医学植入物并实现新的超强材料。 这些技术进步变得可能是可能的，因为纳米级陶瓷的手性可以与它们的特殊机械，光学，电子，化学和生物学特性结合使用。 将建立合成方法，特征性能和计算工具。小颗粒氧化钨的表面将用氨基酸涂覆，这些氨基酸将其手性转移到无机材料中。将发现合成长链分子（称为肽）的最佳条件，并将特定的手性用作生物医学和国防需求的抗菌药物。该项目的结果将是用于应用研究和教育的多功能工具箱，将为其他科学家，工程师，教师和公众提供。 陶瓷材料的低成本，生物相容性和通用性将在许多技术领域都能利用手性陶瓷。 密歇根大学将与底特律地区贫困社区的学校合作，以证明对高中生和中学生的手性重要性。 该项目还将帮助高中时代的儿童言语障碍，以找到化学，物理，材料或数学方面的有趣研究主题。技术摘要是一种几何特性，对物理，化学，生物学，天文学和数学具有统一性。 纳米级陶瓷可以是手性，它将增强这些材料的机械，光学，电子，化学和生物学特性。 这些陶瓷的进步将使新一代材料成为极化调制装置，手性催化剂，生物医学植入物，生物传感器和药物载体。 因此，将在该项目中建立合成方法，特性属性和计算工具的框架。作为模型系统，将合成具有L-和D-氨基酸表面配体的三氧化钨三氧化钨纳米颗粒。 这些纳米胶体随后将用于氨基酸凝结为抗菌肽的催化。熟练在计算和合成工具方面熟练的综合培训对于该项目的影响至关重要。教育和外展工作将集中在代表性不足的少数民族以及来自高支宝贝Ypsilanti地区的中学和高中生。具有言语障碍的高中时代的孩子将参与科学研究。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，被认为值得通过评估来获得支持。

项目成果

Chiromagnetic nanoparticles and gels

• DOI: 10.1126/science.aao7172
• 发表时间: 2018-01
• 期刊: Science
• 影响因子: 56.9
• 作者: Jihyeon Yeom;Uallisson S Santos;Mahshid Chekini;Minjeong Cha;A. F. de Moura;N. Kotov

Terahertz Circular Dichroism Spectroscopy of Molecular Assemblies and Nanostructures

• DOI: 10.1021/jacs.2c04817
• 发表时间: 2022-12-09
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Choi，Won Jin;Lee，Sang Hyun;Kotov，Nicholas A.
• 通讯作者: Kotov，Nicholas A.