STTR Phase I: Rational design of highly sensitive and selective chemical sensors using structural color

STTR第一阶段：利用结构色合理设计高灵敏度和选择性化学传感器

• 批准号: 1746719
• 负责人: Min Hu
• 金额: $ 22.5万
• 依托单位: DrinkSavvy Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1746719&HistoricalAwards=false
• 关键词: STTR; Phase; Rational; design; highly

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project will be the development of sensor-embedded "smart" drinkware (i.e., stirrers, straws and cups) to actively alert consumers prior to consumption of a "spiked" beverage, and thus provide a proactive way to prevent drug-facilitated sexual assault. This sensor technology is based on "smart" molecularly imprinted color-changing nanomaterials that eliminate the need to run tedious sample preparation and analysis procedures using conventional laboratory instrument. The use of a colorimetric sensor as a cost-effective consumer sensor has far broader applications than just date rape drug detection, including applications where on-the-spot detection could help protect consumers from other harmful chemicals, pathogens, drugs, explosives, nerve agents, allergens, etc. In addition, this project will advance colorimetric sensing technology using structural color into a robust and rapid sensing platform for drug monitoring with high sensitivity, response time, and accuracy.This STTR Phase I project proposes to develop a platform technology based on a highly accurate, color-changing sensor that will initially be used to continuously monitor a beverage for date rape drugs, and instantaneously detect these adulterants if they are present. Drug-facilitated sexual assault has become a significant issue, but there is currently no drug-sensing drinkware available on the market. This drug sensor will be implemented using highly selective molecular imprinted polymers as target drug receptors and non-toxic color-changing nanomaterials as signaling reporters. The scope of the research includes the rational design of the color-changing nanomaterial used as a signaling reporter for the target drug binding event, the development of a highly selective molecularly imprinted polymer and its integration with reporters, and the testing of the color-changing sensor under different matrices and conditions to verify its sensitivity and specificity.

这个小型企业技术转移（STTR）项目的更广泛的影响/商业潜力将是开发传感器装饰的“智能”饮料软件（即搅拌器，稻草和杯子），以便在消费“尖刺”饮料之前积极提醒消费者，从而提供一种积极的方式来防止药物侵害性侵犯。 该传感器技术基于“智能”分子烙印颜色改变的纳米材料，这些纳米材料消除了使用常规实验室仪器进行乏味的样品制备和分析程序的需求。 使用比色法传感器作为一种具有成本效益的消费者传感器的应用比仅仅是强奸药物检测的应用要广泛得多，包括应用程序可以帮助保护消费者免受其他有害的化学物质，病原体，药物，爆炸物，神经，神经，神经，过敏剂等的良好型技术的质疑，使消费者免受其他有害的化学物质，病原体，药物，爆炸性，爆炸性，神经，过敏剂等的速度，将其迅速响应，并将其迅速响应，并推动该项目的迅速效果，并促进了迅速的技术效果，使得迅速地进行质量敏感性，并将其迅速响应。该STTR I期项目提议以高度准确，变色的传感器为基础开发平台技术，该传感器最初将用于连续监视约会强奸药物的饮料，并立即检测到这些掺假剂（如果存在）。毒品采用的性侵犯已成为一个重大问题，但目前市场上尚无药物感应饮料软件。该药物传感器将使用高度选择性的分子印迹聚合物作为靶向药物受体和无毒色彩变色的纳米材料作为信号记者。这项研究的范围包括用作目标药物结合事件的信号记者的颜色变化的纳米材料的合理设计，高度选择性的分子烙印聚合物的发展以及与记者的积分，以及在不同的矩阵和条件下的颜色变化传感器的测试，以验证其敏感性和特定性。